Understanding rs35887622: A Genetic Variant and Hearing Health
The genetic variant rs35887622 is a single nucleotide polymorphism located in an intergenic region of the human genome. It has been historically investigated for potential associations with hereditary non-syndromic sensorineural hearing loss, though current evidence suggests its clinical significance remains uncertain.
What each genotype means
Typical hearing profile
This genotype is considered the reference sequence for this location in the GJB2 gene. Research indicates that individuals with this genotype typically exhibit normal hearing, as it does not carry the variant associated with historical reports of non-syndromic sensorineural deafness.
This is the most common genotype observed in most global populations.
Potential carrier status
This genotype indicates you carry one copy of the variant. While early research linked this variant to recessive deafness, more recent studies suggest it is likely benign or associated with only mild, late-onset hearing impairment, and it is currently considered a variant of uncertain significance regarding clinical hearing loss.
This genotype is found in a small percentage of the population, with frequency varying significantly by ancestry.
Uncertain significance
This genotype represents a variant of uncertain significance regarding hearing health. Current scientific consensus has shifted away from the initial reports that linked this variant to hereditary deafness, and it is now frequently categorized as likely benign or having no clear clinical impact.
This genotype is relatively uncommon and observed at low frequencies across most studied populations.
Uncertain significance
This genotype is a variant of uncertain significance. Although it was historically investigated for a potential link to non-syndromic sensorineural deafness, modern evidence suggests it is likely benign or has a negligible effect on hearing, and it should not be used to predict clinical hearing outcomes.
This genotype is rare, occurring in less than 1% of most populations.
What is rs35887622?
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs35887622 is an intergenic SNP, meaning it is located in the DNA sequence between genes rather than within a gene that codes for a protein. Because it does not sit within a protein-coding region, researchers often study such variants to determine if they influence the regulation of nearby genes or if they serve as markers for other nearby genetic changes. In the context of genomic research, rs35887622 is cataloged in major databases like dbSNP, which track these variations across human populations to help scientists understand the landscape of human genetic diversity.
Research and Associations
Early research into rs35887622 suggested a potential link to hereditary non-syndromic sensorineural deafness. However, the scientific consensus has evolved as more data has become available. More recent evaluations indicate that the association is not as clear-cut as initially reported. Some studies suggest the variant may be benign, while others propose it might be associated with mild, late-onset hearing impairment. Because the evidence is mixed and the variant is often found in healthy individuals, it is currently classified with limited or uncertain clinical significance in many genetic databases. It is important to recognize that genetic associations identified in early studies often require replication in larger, more diverse cohorts to confirm their validity and clinical relevance.
Population Frequency
The frequency of the alleles at the rs35887622 position varies significantly across different ancestral populations. Genetic databases like gnomAD and the 1000 Genomes Project provide data on how often specific alleles appear in various global groups. For rs35887622, the global minor allele frequency is approximately 0.0096, though this number is an average and does not reflect the specific distribution within any single ethnic or geographic group. Understanding these frequency differences is a cornerstone of modern genomics, as it helps researchers distinguish between rare, potentially pathogenic variants and common variations that are simply part of normal human diversity. When interpreting genetic data, researchers always consider the population background of the individual to ensure accurate context.
Navigating Genetic Information
If you have received information about your rs35887622 genotype, it is essential to approach it with a clear understanding of its limitations. This variant is not a diagnostic tool for hearing loss, and the presence of any specific genotype does not guarantee a particular health outcome. Genetic testing results should never be used to make medical decisions without the guidance of a qualified healthcare professional. If you have concerns about your hearing or your family history, the most appropriate step is to consult with an audiologist or a medical geneticist. These professionals can provide context based on your personal health history, physical examinations, and clinical testing, which are far more reliable than looking at a single genetic variant in isolation.
How common is this variant?
The variant rs35887622 is relatively frequent, with a global minor allele frequency of approximately 0.0096, though this frequency varies by ancestry.
Frequently asked questions
Is rs35887622 a cause of deafness?
While early reports suggested an association with hereditary deafness, current evidence is mixed and often points toward the variant being benign or having a very limited impact. It is not considered a definitive cause of hearing loss.
Should I be worried if I have this variant?
No, the presence of this variant does not mean you will experience hearing loss. Many people with this variant have normal hearing, and it is considered a common genetic variation.
Where can I find more information on this SNP?
You can look up rs35887622 in public databases like dbSNP or the GWAS Catalog. These resources provide the most up-to-date scientific literature and population data.
Can a doctor use this to diagnose me?
No, this variant is not used for clinical diagnosis. A diagnosis of hearing loss is based on clinical evaluations, such as hearing tests performed by an audiologist.
Sources & further reading
Educational information only, last refreshed 10/3/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs35887622?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants
This variant acts as a hub gene marker associated with Th17 immune responses and hypo-inflammation in critically ill trauma patients.
This variant in the IL2/IL21 locus shows genome-wide significant association with ulcerative colitis.
An intronic regulatory variant in the LPP gene strongly associated with serum allergen-specific IgE levels and allergic rhinitis susceptibility.
A well-replicated intronic polymorphism in LPP associated with multi-allergen sensitization, including cat dander, dust mites, and grass pollen.
This intronic variant in the CASP8 gene is linked to prostate cancer risk assessment models.
This intronic variant is associated with improved risk stratification for clinically significant prostate cancer.