Understanding rs35941406: A Regulatory Variant in LOC112272571
The genetic variant rs35941406 is a single nucleotide polymorphism located within a non-coding regulatory region of the human genome associated with the gene LOC112272571. Current research identifies this site as a potential regulatory element, though it is generally considered benign in clinical contexts.
What each genotype means
Typical regulatory variant profile
This genotype represents the common sequence at this location. Current research identifies this site as a regulatory region, but there is no evidence suggesting this specific sequence confers any clinical trait or health risk.
This is the most frequently observed genotype across global populations.
Typical regulatory variant profile
This genotype indicates the presence of one copy of the variant allele. As this variant is located in a regulatory region and is annotated as benign in clinical databases, it is not expected to have a significant impact on your health or biological function.
This genotype is observed at varying frequencies depending on ancestral background, though it remains a common variation.
Typical regulatory variant profile
This genotype indicates the presence of two copies of the variant allele. While this site is identified as a regulatory element, the variant is classified as benign, meaning it is not associated with any known clinical conditions or health traits.
This genotype is less common than the homozygous reference state but is present in the general population.
What is rs35941406?
The variant rs35941406 is a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This specific variant is located within a region of the genome identified as a regulatory element. Regulatory regions are segments of DNA that do not code for proteins themselves but instead act as switches or control centers that determine when and how much of a nearby gene is expressed. By studying these non-coding regions, scientists can better understand the complex machinery that regulates cellular function. Because rs35941406 is situated in a non-coding area, it does not alter the structure of a protein directly, but it may influence the efficiency or timing of gene activity in specific tissues.
The Role of LOC112272571
The variant rs35941406 is associated with the genomic locus identified as LOC112272571. In genomics, 'LOC' identifiers are often assigned to regions that have been predicted to have biological activity but may not yet be fully characterized as traditional protein-coding genes. Research using techniques like SHARPR-MPRA (Massively Parallel Reporter Assays) has highlighted this region as a functional regulatory element. These assays allow researchers to measure the activating or repressive capabilities of specific DNA sequences within a cell. While the exact biological pathway controlled by this locus is still being mapped, its classification as a regulatory region suggests it plays a role in the fine-tuning of gene expression, which is essential for normal development and cellular homeostasis.
Research and Clinical Significance
In the context of clinical genetics, rs35941406 is currently annotated as benign. This classification is based on existing data from clinical databases, which aggregate information from various studies to determine the potential impact of a variant on human health. When a variant is labeled as benign, it means that current evidence does not link it to any specific disease or adverse health condition. The evidence strength for this variant is considered moderate, reflecting that while it has been identified and studied in high-resolution regulatory profiling experiments, it has not been implicated in clinical pathology. It is important to remember that genetic research is an evolving field, and as more data becomes available, our understanding of such variants may continue to be refined.
Interpreting Your Genetic Information
Information regarding variants like rs35941406 is often found in direct-to-consumer genetic reports or large-scale genomic studies. Because this variant is classified as benign and is located in a non-coding regulatory region, it is generally not considered a factor in medical decision-making or diagnostic screening. If you encounter this variant in a personal report, it is helpful to view it as a piece of the vast, normal variation that exists between all humans. You cannot use this information to diagnose a condition or predict a specific health outcome. If you have concerns about your genetic health or specific traits, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor who can help you interpret your results within the context of your overall medical history.
How common is this variant?
Specific population frequency data for rs35941406 is not currently provided in major public catalogs, indicating that it is a standard variant observed across diverse ancestral groups.
Frequently asked questions
Is rs35941406 associated with any diseases?
No, rs35941406 is currently annotated as benign in clinical databases. There is no evidence linking this variant to any specific disease or health condition.
What does it mean if a variant is in a regulatory region?
A variant in a regulatory region is located in a part of the DNA that controls gene expression. It does not change the protein itself but may influence how much of a protein is produced.
Should I be worried about this variant in my report?
No, there is no reason for concern. This variant is considered a normal part of human genetic variation and is not used for medical diagnosis.
Where can I find more information about this SNP?
You can search for the rsID on public databases like the NCBI SNP database or the GWAS Catalog. These resources provide the most up-to-date scientific information on specific genetic variants.
Sources & further reading
Educational information only, last refreshed 9/14/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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