CDH18 rs369563433: Understanding This Genetic Variant
The genetic variant rs369563433 is a specific change in the DNA sequence located within the CDH18 gene. Research has identified this variant as being associated with variations in the measurement of glioma pathogenesis-related protein 1 in the human body.
What each genotype means
Typical genetic profile
This genotype represents the most common form of this variant found in the general population. Research indicates this specific genetic sequence is associated with variations in glioma pathogenesis-related protein 1 measurements, though the clinical significance of these variations remains under investigation.
This is the most frequent genotype observed across most global populations.
Variant carrier profile
Carrying one copy of the G allele is associated with variations in glioma pathogenesis-related protein 1 measurements. Because this variant is rare, the full extent of its biological impact is not yet fully understood, and it should not be used to predict specific health outcomes.
This genotype is rare and observed at low frequencies across most ancestral groups.
Rare variant profile
This genotype represents the rare homozygous state for this variant. While it is associated with variations in glioma pathogenesis-related protein 1 measurements in research studies, the evidence is limited and does not imply a specific medical condition or diagnostic outcome.
This genotype is extremely rare and is found in a very small fraction of the population.
What is rs369563433?
The identifier rs369563433 refers to a single nucleotide polymorphism, or SNP, which is a common type of genetic variation where a single building block of DNA—a nucleotide—is replaced by another. In the case of rs369563433, this variation is situated within the CDH18 gene on chromosome 5. Scientists track these specific locations using 'rs' numbers to study how differences in our genetic code might influence biological traits or susceptibility to certain conditions. Because this variant is located in a specific region of the genome, researchers analyze it to see if it correlates with measurable differences in protein levels or other physiological markers. It is important to note that identifying a SNP is only the first step in understanding its potential impact, as most genetic variants have very subtle effects on overall health and are influenced by a complex interplay of other genes and environmental factors.
The Role of the CDH18 Gene
The CDH18 gene provides instructions for making a protein called cadherin-18. This protein belongs to a family of molecules known as cadherins, which are essential for cell-cell adhesion. Cadherin-18 is primarily expressed in the central nervous system, where it plays a critical role in how cells communicate and organize themselves into tissues. By facilitating homophilic adhesion—where similar cells stick together—this protein helps in the assembly of cell junctions, which are vital for maintaining the structural integrity of brain tissue. Beyond simple adhesion, cadherin-18 is thought to be involved in complex processes such as axon outgrowth and guidance, which are fundamental to the development and maintenance of neural networks. Because of its high expression in the brain, researchers are particularly interested in how variations in this gene might influence neurological development or the regulation of proteins associated with brain-related pathways.
Research Associations and Evidence
The association between rs369563433 and glioma pathogenesis-related protein 1 (GLIPR1) measurements has been identified through genome-wide association studies (GWAS). These studies look across the entire genome to find statistical links between specific genetic variants and measurable traits. While the evidence linking this SNP to GLIPR1 levels is documented in scientific databases, it is categorized as having moderate strength. This means that while a statistical correlation exists, it does not necessarily imply a direct cause-and-effect relationship, nor does it indicate a clinical diagnosis. The biological mechanism by which this specific SNP influences protein levels is still a subject of ongoing research. In the context of genomics, 'moderate' evidence suggests that while the finding is reproducible in certain datasets, it is one of many factors that contribute to the variability of protein levels in the population, and it should be interpreted with caution.
Interpreting Your Genetic Information
When you encounter information about genetic variants like rs369563433, it is important to understand that this data is for educational purposes only. Genetic associations are statistical observations made across large groups of people and do not predict individual health outcomes. You cannot use this information to diagnose yourself with a condition or to make medical decisions. If you have questions about your genetic profile or how specific variants might relate to your health, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your results in the context of your personal and family medical history. Furthermore, never make changes to your medications or lifestyle based on genetic reports without first discussing them with your clinician or pharmacist, as they are the only ones qualified to provide personalized medical advice.
How common is this variant?
The rs369563433 variant is considered rare across most global populations. Specific frequency data can vary significantly depending on ancestral background, and it is recommended to consult the gnomAD database for the most current, population-specific statistics.
Frequently asked questions
What does it mean if I have the rs369563433 variant?
Having this variant simply means you carry a specific DNA sequence at a particular location in the CDH18 gene. It is a normal part of human genetic diversity and does not indicate a disease or a medical condition.
Can I use this SNP to predict my risk of glioma?
No. While this SNP is associated with measurements of a protein related to glioma pathogenesis, it is not a diagnostic tool for glioma. Genetic risk is complex and involves many factors beyond a single variant.
Where can I find more information about CDH18?
You can find detailed information about the CDH18 gene on resources like the National Library of Medicine's MedlinePlus Genetics or the GeneCards database. These sites provide comprehensive summaries of gene function and related research.
Is this variant common in my ancestry?
The frequency of this variant varies by population. You can check the gnomAD browser to see how common this specific SNP is in different ancestral groups, as it is generally classified as rare.
Sources & further reading
Educational information only, last refreshed 10/2/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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