FAM189A2 rs3750552: What Your Genotype Means
The genetic variant rs3750552 is a single nucleotide polymorphism located near the FAM189A2 gene on chromosome 9. Research has identified this variant as being associated with susceptibility to allergic diseases in various adult and adolescent cohorts.
What each genotype means
Typical allergic disease susceptibility
You carry two copies of the C allele at rs3750552 near the FAM189A2 gene. In genome-wide association studies evaluating allergic conditions, this genotype represents the baseline or non-risk genetic profile. Current evidence linking this locus to allergy susceptibility is limited, and this genotype is not associated with an elevated risk of allergic traits.
Carried by approximately 55% to 60% of individuals globally, and by roughly two-thirds of individuals of East Asian ancestry.
Modestly increased allergy susceptibility
You carry one copy of the T allele at rs3750552 near the FAM189A2 gene. In observational association studies, carrying one copy of this minor allele has been statistically linked to a modest increase in susceptibility to allergic conditions, such as allergic rhinitis and atopic dermatitis. However, evidence remains limited and complex allergic conditions are heavily influenced by environmental exposures and many other genetic factors.
Carried by approximately 35% to 40% of individuals in global populations, and by roughly 30% of individuals of East Asian ancestry.
Moderately increased allergy susceptibility
You carry two copies of the T allele at rs3750552 near the FAM189A2 gene. Observational research in adolescent and adult cohorts indicates that having two copies of this variant is statistically associated with higher susceptibility to allergic diseases compared to the non-risk genotype. Because the published evidence base for this specific locus is limited, this genetic finding reflects a modest statistical association rather than a certainty of developing allergic symptoms.
Carried by roughly 5% to 7% of individuals globally and only about 3% to 4% of individuals in East Asian cohorts.
Understanding rs3750552
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs3750552 is located at the 9q21.12 region of the human genome. In the context of genetic research, SNPs like rs3750552 serve as markers that help scientists identify regions of the genome that may contribute to complex traits or disease susceptibility. Because this variant is located near the FAM189A2 gene, researchers often investigate whether the variant influences the expression or function of this specific gene, though the exact biological mechanism remains a subject of ongoing study. It is important to note that the presence of a specific SNP does not guarantee the development of a trait; rather, it indicates a statistical correlation observed in large-scale population studies.
The Role of FAM189A2
The FAM189A2 gene, also known as C9orf11, is located in the region where the rs3750552 variant is found. While the specific functions of the FAM189A2 protein are still being characterized by the scientific community, some research suggests potential involvement in cellular processes such as neuronal differentiation. In the context of allergic disease, researchers look for genes that might regulate immune responses or barrier functions. Because rs3750552 is situated in proximity to this gene, it is a candidate for further investigation to determine if it acts as a regulatory element that alters how FAM189A2 is expressed in tissues relevant to allergic inflammation. Current evidence is considered limited, meaning that while associations have been reported, the functional link between this gene and allergic disease requires more robust experimental validation.
Research and Allergic Disease
Genome-wide association studies (GWAS) have been instrumental in identifying genetic risk factors for complex conditions like allergic rhinitis and other allergic diseases. The variant rs3750552 has been highlighted in studies examining susceptibility to these conditions. These studies compare the genomes of individuals with allergic diseases against those without to find patterns that occur more frequently in the affected group. The evidence for rs3750552 is currently categorized as limited, which reflects the modest effect sizes typically seen in complex, polygenic traits where many genes contribute small amounts to overall risk. Because allergic diseases are influenced by a combination of genetic, environmental, and lifestyle factors, this SNP should be viewed as one small piece of a much larger, complex puzzle rather than a definitive diagnostic marker.
Interpreting Your Genetic Information
When you encounter information about variants like rs3750552, it is essential to understand that this data is for educational purposes only. Genetic associations identified in research cohorts are statistical in nature and do not constitute a medical diagnosis. You cannot use this information to predict your personal health outcomes or to make decisions about medical treatments. If you have concerns about allergies or your immune health, the most appropriate course of action is to consult with a qualified healthcare professional, such as an allergist or primary care physician. They can provide personalized advice based on your clinical history, symptoms, and physical examinations, which are far more predictive of your health status than any single genetic variant.
How common is this variant?
The minor allele frequency for rs3750552 is approximately 0.18 in East Asian populations and approximately 0.25 across global populations.
Frequently asked questions
Does having the rs3750552 variant mean I will develop allergies?
No, having this variant does not mean you will develop allergies. Genetic associations are statistical, and many other factors, including your environment and immune system, play a much larger role in the development of allergic diseases.
What is the FAM189A2 gene?
FAM189A2 is a gene located on chromosome 9. While its exact biological role is still being researched, it is being studied for its potential involvement in cellular processes and its proximity to genetic markers associated with allergic traits.
Can I use this information to change my diet or lifestyle?
You should not use genetic association data to make changes to your diet or lifestyle. Always consult with a healthcare provider or a registered dietitian before making significant changes to your health regimen.
Where can I find more information about this SNP?
You can find more information through reputable scientific databases such as the GWAS Catalog or the NCBI SNP database. These resources provide curated data from peer-reviewed research studies.
Sources & further reading
Educational information only, last refreshed 10/19/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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