FLT1 rs3794396: Understanding the Longevity-Associated Variant
The rs3794396 variant is a single nucleotide polymorphism located within the FLT1 gene. Research has identified this specific marker as being associated with human longevity, potentially by influencing cardiovascular health and mortality risk.
What each genotype means
Baseline longevity profile
This is the major allele genotype for this variant. Research suggests that individuals with this genotype may not receive the same protective benefit against hypertension-related mortality as those carrying the minor allele.
This is the most common genotype, observed in the majority of individuals in studied cohorts.
Potential longevity-associated profile
Carrying one copy of the minor allele is associated with potential longevity benefits. Research indicates this genotype may help mitigate mortality risks associated with hypertension as you age.
This genotype is found in a smaller subset of the population compared to the major allele homozygotes.
Enhanced longevity-associated profile
This genotype represents the minor allele homozygote, which has been identified in research as having a significant association with human longevity. It is hypothesized to provide protection against mortality risks posed by age-related conditions like hypertension.
This is the least common genotype for this variant, appearing in a small fraction of the population.
What is rs3794396 and Where is it Located?
The rs3794396 variant is a specific genetic change, or single nucleotide polymorphism (SNP), situated within the FLT1 gene. In human genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. The FLT1 gene itself is located on chromosome 13 at position 13q12.3. As a tag SNP, rs3794396 serves as a marker that researchers use to identify or track specific regions of the genome that may be inherited together. By studying this location, scientists aim to understand how variations in this specific part of the genetic code might correlate with complex human traits, such as the ability to reach an advanced age.
The Role of the FLT1 Gene
The FLT1 gene encodes the Fms-related receptor tyrosine kinase 1, which is also known as VEGFR1 (Vascular Endothelial Growth Factor Receptor 1). This protein is a member of the vascular endothelial growth factor receptor family, which plays a critical role in the development and maintenance of the vascular system. VEGFR1 is primarily involved in angiogenesis, the process by which new blood vessels form from pre-existing ones. Because the health of the cardiovascular system is a major determinant of overall longevity, the function of FLT1 is of significant interest to researchers studying aging. By regulating how blood vessels grow and respond to signals, the protein produced by this gene helps maintain the integrity of the circulatory system throughout a person's life.
Research Associations with Longevity
Scientific literature has identified a statistical association between the rs3794396 variant and human longevity. Some studies suggest that specific genotypes at this locus may confer a survival advantage by potentially reducing the mortality risk associated with hypertension, or high blood pressure. While these findings are compelling, it is important to note that the evidence strength for this association is considered moderate. Longevity is a complex, polygenic trait, meaning it is influenced by hundreds or thousands of genetic variants working in concert with environmental factors, lifestyle choices, and chance. Therefore, while rs3794396 is a notable marker in the study of aging, it is only one small piece of a much larger and highly intricate biological puzzle.
Understanding Your Results
It is essential to understand that genetic associations with longevity are based on population-level statistics rather than individual predictions. Having a specific genotype associated with longevity does not guarantee a longer life, nor does the absence of one preclude it. Genetic information should never be used to diagnose health conditions or to make medical decisions. If you are concerned about your cardiovascular health or your risk for conditions like hypertension, you should consult with a qualified healthcare provider or a cardiologist. They can provide personalized assessments based on your clinical history, physical exams, and standard diagnostic testing. Genetic data is a tool for scientific exploration and should not replace professional medical advice or standard preventative care.
How common is this variant?
The frequency of the rs3794396 alleles varies across different ancestral populations. Specific frequency data for this variant is not consistently recorded in major public databases, reflecting the need for more diverse genomic studies.
Frequently asked questions
Does having the 'longevity' genotype guarantee I will live to 100?
No. Longevity is influenced by a complex combination of genetics, environment, and lifestyle. A single genetic variant like rs3794396 provides only a very small statistical contribution to the overall probability of reaching an advanced age.
Can I use this information to change my diet or exercise?
You should not change your health habits based solely on a single genetic variant. Always discuss your health, diet, and exercise goals with a doctor or a registered dietitian who can provide advice tailored to your specific medical history.
Is FLT1 related to heart disease?
Yes, the FLT1 gene is involved in the regulation of blood vessels. Research suggests that variants in this gene may influence cardiovascular health, which is a primary factor in determining lifespan and mortality risk.
Where can I find more information about my specific genotype?
You can look up your rsID in public databases like dbSNP or the GWAS Catalog. However, these resources are designed for researchers and may be difficult to interpret without a background in genetics.
Sources & further reading
Educational information only, last refreshed 9/23/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs3794396?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants in FLT1
Coding variant in VEGFR1 (FLT1) altering codon usage and receptor expression levels, associated with progression-free survival under bevacizumab anti-angiogenic therapy.
Variant in the FLT1 (VEGFR1) locus associated with variations in retinal vascular caliber and susceptibility to diabetic retinopathy.