IRF5 rs3807306: What Your Genotype Means
The rs3807306 variant is a genetic marker located within the IRF5 gene. It is recognized as a significant genetic factor influencing susceptibility to certain health conditions, including renal cell carcinoma.
What each genotype means
Typical renal cancer risk
This genotype represents the baseline for this variant. While this variant is recognized as a factor influencing susceptibility to renal cell carcinoma, the association is primarily observed in specific cohorts such as Han Chinese populations.
Frequency varies significantly by ancestry.
Potential renal cancer risk
This genotype is associated with a potential change in susceptibility to renal cell carcinoma. The clinical significance of this association varies by ancestry, and it is most notably studied in Han Chinese populations.
Frequency varies significantly by ancestry.
Potential renal cancer risk
This genotype is associated with a potential change in susceptibility to renal cell carcinoma. The clinical significance of this association varies by ancestry, and it is most notably studied in Han Chinese populations.
Frequency varies significantly by ancestry.
Understanding the Variant and Its Location
The rs3807306 variant is a single nucleotide polymorphism (SNP) located within the IRF5 gene. This gene, which stands for Interferon Regulatory Factor 5, is situated on chromosome 7. The IRF5 protein is a transcription factor that plays a vital role in the immune system. It is primarily involved in regulating the expression of genes that control inflammation and the body's response to infections. Specifically, IRF5 helps coordinate the activity of immune cells like macrophages and B cells. Because of its central role in immune signaling, variations in the IRF5 gene are frequently studied in the context of autoimmune diseases and inflammatory conditions, as well as in the development of certain types of cancer where immune regulation is a factor.
Research Associations and Evidence Strength
Research has identified rs3807306 as a significant genetic factor associated with susceptibility to renal cell carcinoma. The evidence for this association is generally considered moderate, meaning that while multiple studies have observed a link, the biological mechanisms are complex and involve interactions with other genetic and environmental factors. The variant has also been studied in relation to other conditions, such as multiple sclerosis and chronic kidney disease, reflecting the broad role of the IRF5 gene in immune system function. In some populations, particularly Han Chinese cohorts, this variant has been a focus of investigation to understand how specific genetic profiles might influence cancer risk. Because the IRF5 gene is involved in complex inflammatory pathways, the exact way this SNP contributes to disease risk is still an active area of scientific inquiry.
What This Information Means for You
It is important to recognize that genetic associations like those found for rs3807306 are based on statistical trends in large populations and do not provide a diagnosis for any individual. Having a specific genotype does not mean you will develop renal cell carcinoma or any other condition. Many factors, including lifestyle, environmental exposures, and overall health, are far more influential in determining your risk than a single genetic variant. You cannot use this information to make medical decisions or to assess your personal health risk. If you have concerns about your health or family history, you should speak with a qualified healthcare professional. They can provide appropriate screenings and advice based on your individual clinical profile, which is the only reliable way to manage your health.
How common is this variant?
The frequency of the rs3807306 variant varies significantly by ancestry. It has been notably studied in Han Chinese cohorts, where specific allele frequencies have been documented.
Frequently asked questions
Does having this variant mean I will get kidney cancer?
No. This variant is a statistical marker associated with risk in population studies, not a diagnostic test. Most people with this variant will never develop kidney cancer.
Is IRF5 involved in autoimmune diseases?
Yes, the IRF5 gene is well-known for its role in immune regulation, and variants in this gene have been associated with several autoimmune conditions in scientific literature.
Can I use this information to prevent disease?
No. You should not use genetic data to guide medical prevention strategies. Focus on established health practices like regular check-ups and healthy lifestyle choices.
Where can I find more information on this SNP?
You can look up rs3807306 on the NCBI dbSNP database or the GWAS Catalog to find peer-reviewed research and detailed population frequency data.
Sources & further reading
Educational information only, last refreshed 11/4/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs3807306?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29