FEN1 rs4246215: what the research says
A variant in the FEN1 gene linked to the pathogenesis of oxidative stress-related corneal diseases.
What each genotype means
Common genotype
This is the most common genotype observed in many populations. Research into this variant has explored its potential role in DNA repair and oxidative stress, but current evidence does not establish this genotype as a significant risk factor for specific clinical conditions.
This is the major homozygous genotype found in the majority of individuals across most global populations.
Heterozygous genotype
You carry one copy of the T allele. While some studies have investigated the T allele in the context of DNA repair efficiency and disease susceptibility, the evidence remains limited and inconsistent, and this genotype is not considered a diagnostic indicator for any specific health condition.
This genotype is found at varying frequencies depending on ancestry, generally appearing in a minority of the population.
Minority genotype
You carry two copies of the T allele. Some research has examined this variant for potential associations with oxidative stress-related pathways or disease risk, but findings are mixed and often lack statistical significance in larger studies. This genotype is not a clinical diagnosis and should not be used to predict individual health outcomes.
This is the least common genotype, occurring at a low frequency in most studied populations.
Variable
Curious what your genotype is for rs4246215?
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