CLOCK rs4580704: Understanding Your Genetic Variant
The rs4580704 variant is a common genetic polymorphism located within the CLOCK gene, which plays a central role in regulating circadian rhythms. Research has explored its potential associations with metabolic health markers, dietary energy intake, and sleep-related patterns in various populations.
What each genotype means
Typical metabolic profile
This genotype represents the most common version of this variant in many populations. Research suggests that individuals with this genotype may have different metabolic responses to dietary fat intake compared to those carrying the G allele. Because associations between this gene and metabolic health are complex and influenced by diet and lifestyle, this result should not be used to predict specific health outcomes.
This is the most common genotype observed in many global populations.
Potential metabolic sensitivity
Carrying one copy of the G allele has been associated in some studies with variations in metabolic markers, such as insulin sensitivity and glucose levels, particularly when dietary fat intake is high. These findings are based on statistical associations in specific research cohorts and do not indicate a direct cause-and-effect relationship. Please discuss any concerns regarding your metabolic health or dietary patterns with a qualified healthcare provider.
This genotype is found at moderate frequencies across various ancestral groups.
Potential metabolic sensitivity
Individuals with this genotype carry two copies of the minor G allele, which has been linked in some research to differences in metabolic parameters and dietary energy intake. While some studies suggest this allele may be associated with specific responses to dietary fat, the evidence is mixed and often dependent on the specific population studied. These results are for informational purposes and should not be used to diagnose or manage health conditions.
This is the least common genotype for this variant in many populations.
What is rs4580704?
The rs4580704 variant is a single-nucleotide polymorphism (SNP) found within the CLOCK gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is located in a region of the genome that influences the expression and function of the CLOCK protein. Because it is a common variant, it is frequently studied in the context of complex traits that involve biological timing. Scientists track these variations to understand how subtle differences in our genetic code might contribute to individual differences in physiological processes, such as how our bodies manage energy or respond to daily light-dark cycles.
The Role of the CLOCK Gene
The CLOCK gene encodes a protein that acts as a core component of the molecular circadian clock, the internal system that regulates our 24-hour biological rhythms. This system governs a wide array of physiological functions, including sleep-wake cycles, hormone release, body temperature, and metabolism. By interacting with other clock proteins, the CLOCK protein helps drive the rhythmic expression of many other genes throughout the body. Because this system is so fundamental to human health, researchers are highly interested in how genetic variations within the CLOCK gene might influence the precision or robustness of these internal rhythms, potentially impacting how we process food or maintain metabolic balance.
Research and Evidence
Evidence regarding rs4580704 is considered moderate and often context-dependent. Some studies have observed associations between this variant and metabolic markers, such as body mass index (BMI) and type 2 diabetes incidence, though results have been mixed across different cohorts. For instance, some research has suggested that carriers of the minor G allele may show differences in dietary energy intake or breakfast frequency, while other large-scale studies have failed to find significant links to sleep quality or specific chronotypes. It is important to note that many of these findings are based on observational studies, and the strength of the association can vary significantly depending on the population studied, dietary habits, and environmental factors.
Interpreting Your Information
Genetic information regarding variants like rs4580704 should be viewed as a piece of a much larger puzzle. While research highlights potential statistical associations with metabolic or behavioral traits, these findings do not constitute a medical diagnosis or a prediction of your personal health outcomes. Many factors, including lifestyle, diet, physical activity, and other genetic variants, play a much larger role in determining your health than any single SNP. If you are concerned about your metabolic health, sleep patterns, or dietary habits, it is essential to consult with a qualified healthcare professional or a registered dietitian. They can provide personalized guidance based on your clinical history rather than relying on individual genetic markers.
How common is this variant?
The rs4580704 variant is considered a common polymorphism, meaning it is found at significant frequencies across diverse human populations.
Frequently asked questions
Does rs4580704 cause sleep disorders?
No. While the CLOCK gene is involved in circadian rhythms, current research has not established a direct causal link between the rs4580704 variant and the development of clinical sleep disorders.
Can I use this SNP to predict my risk of obesity?
No. Genetic variants like rs4580704 are only one of many factors that influence body weight. Obesity is a complex condition driven by a combination of genetics, environment, and lifestyle choices.
Should I change my diet based on my rs4580704 genotype?
You should not make dietary changes based solely on this genetic variant. Always consult with a doctor or a registered dietitian before making significant changes to your nutrition plan.
Is this variant the same as the CLOCK 3111 T/C variant?
No. The rs4580704 variant is a distinct SNP from the well-studied rs1801260 (often referred to as 3111 T/C). While both are in the CLOCK gene, they are separate genetic markers.
Sources & further reading
Educational information only, last refreshed 10/27/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant in the CLOCK gene is associated with variations in circadian rhythm, chrononutrition, and metabolic parameters in adolescents.
Carriers of the T allele are associated with significantly shorter sleep duration.
Widely studied 3-prime UTR single nucleotide polymorphism (3111T/C) in CLOCK that influences individual evening chronotype, delayed sleep timing, and daytime sleepiness.
A 3-UTR single nucleotide polymorphism in the core CLOCK gene associated with evening chronotype.
3' UTR polymorphism in the core circadian regulator gene associated with evening chronotype ('night owl' tendency) and delayed sleep phase.
CLOCK 3111T/C variant influences circadian timing; associated with eveningness and sleep-schedule preference.