Understanding rs4725563: A Common Genetic Variant
The genetic variant rs4725563 is a common single nucleotide polymorphism (SNP) located on chromosome 7. It has been investigated in scientific literature for potential associations with cardiovascular health outcomes, though evidence remains limited.
What each genotype means
Common genetic variant
This genotype represents one of the common forms of this variant. Research has investigated this site in the context of eicosanoid gene variation and cardiovascular health, but current evidence does not establish a definitive clinical impact for this specific genotype.
This is a common genotype found in many populations worldwide.
Common genetic variant
This genotype represents a heterozygous state for this variant. While this site has been studied in relation to cardiovascular outcomes, there is no clear evidence that carrying one copy of the T allele significantly alters health outcomes or disease risk.
This genotype is frequently observed across diverse ancestral groups.
Common genetic variant
This genotype represents the alternative homozygous state for this variant. Scientific literature has explored this variant in association studies, but it is not currently linked to any specific clinical condition or diagnostic outcome.
This genotype is present at a moderate frequency in the general population.
What is rs4725563?
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs4725563 is located on chromosome 7 at position 139,954,547 (GRCh38). This specific location is situated near the TBXAS1 gene, which encodes the enzyme thromboxane A2 synthase. Because it is located in this genomic region, researchers have often included it in studies examining pathways related to eicosanoid metabolism and vascular function. It is important to note that being a 'common' variant means that a significant portion of the global population carries one or both of the alternative alleles at this position. In the context of genomics, rs4725563 is categorized as a trait-associated variant, meaning it has been flagged in various association studies for further investigation into its potential biological impact.
The Role of Nearby Genes
While rs4725563 is often discussed in the context of the TBXAS1 gene, it is essential to understand that the variant itself is a marker. The TBXAS1 gene is responsible for producing thromboxane synthase, an enzyme that plays a critical role in the production of thromboxane A2. Thromboxane A2 is a lipid mediator that promotes platelet aggregation and the constriction of blood vessels. Because of this function, variations in or near this gene are frequently studied to see if they influence the risk of cardiovascular events, such as myocardial infarction or ischemic stroke. However, the presence of a SNP near a gene does not automatically mean the SNP alters the gene's function. It may simply be inherited alongside other functional variations, or it may have no measurable effect on the protein product at all.
Research and Evidence Strength
The evidence linking rs4725563 to specific health outcomes is considered moderate. Scientific research, such as studies published in journals like those indexed in PubMed, has explored whether this variant correlates with non-fatal myocardial infarction or ischemic stroke. These studies often look for statistical correlations across large groups of people. While some initial findings may suggest a link, it is common in genomics for early associations to be refined or challenged as larger, more diverse cohorts are studied. Currently, there is no consensus that this variant serves as a definitive predictor for any specific medical condition. Genomic associations are statistical in nature and do not imply direct causation. Readers should view these findings as part of a broader, ongoing scientific inquiry rather than as a diagnostic tool for personal health management.
Interpreting Your Information
If you have received information about your rs4725563 genotype, it is important to understand what you can and cannot do with this data. This information is intended for educational purposes and should not be used to make medical decisions. Because the evidence for this variant is not definitive, it cannot be used to diagnose, treat, or predict your personal risk for cardiovascular disease. If you are concerned about your heart health or have questions about your genetic profile, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your results in the context of your overall health history, lifestyle, and other established risk factors. Never change your medication or health regimen based on information from a genetic report without first discussing it with your clinician or pharmacist.
How common is this variant?
The variant rs4725563 is common, with a global minor allele frequency reported at approximately 0.24 in various genomic databases.
Frequently asked questions
Is rs4725563 a dangerous mutation?
No, rs4725563 is a common genetic variant, not a disease-causing mutation. It is a normal variation found in a large percentage of the human population.
Does this variant mean I will have a heart attack?
No. Genetic associations are statistical observations across large groups and do not predict individual health outcomes. Many factors, including lifestyle and environment, play a much larger role in cardiovascular health.
Where can I find more information on this SNP?
You can search for the rsID on public databases like the NCBI dbSNP website or the GWAS Catalog. These resources provide the most up-to-date scientific data on known associations.
Should I tell my doctor about this result?
You can share any health information with your doctor, but they will likely focus on established clinical markers like blood pressure and cholesterol. Genetic variants with moderate or limited evidence are rarely used in routine clinical practice.
Sources & further reading
Educational information only, last refreshed 10/6/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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