PGR rs500760: Understanding This Progesterone Receptor Variant
The rs500760 variant is a single nucleotide polymorphism located within the PGR gene, which encodes the progesterone receptor. It has been studied as a potential genetic marker associated with the risk of developing endometriosis in reproductive-age women.
What each genotype means
Typical progesterone receptor profile
This genotype represents the most common form of this variant in many populations. Research into this specific marker has explored its potential role in reproductive health, though current evidence regarding its clinical impact on endometriosis risk remains limited and inconclusive.
This is the most frequent genotype observed in many global populations.
Common variant carrier
Carrying one copy of the G allele is a common occurrence in the general population. While this variant in the PGR gene has been studied as a potential marker for reproductive conditions like endometriosis, the statistical association is weak and findings have been inconsistent across different research cohorts.
This genotype is found in a significant portion of the population across various ancestries.
Variant carrier
This genotype represents the presence of two copies of the G allele. While some studies have investigated this variant as a potential marker for endometriosis risk, the evidence is not definitive and the observed effects are considered very small. It is important to view this information as a research-based observation rather than a diagnostic indicator.
This genotype is less common than the A/A or A/G genotypes but is still frequently observed in the general population.
What is rs500760?
The variant rs500760 is a specific change in the DNA sequence located on chromosome 11 within the PGR gene. In genetics, a single nucleotide polymorphism, or SNP, represents a variation at a single position in the DNA building blocks. This particular SNP is found in the progesterone receptor gene, which provides instructions for creating a protein that allows the body to respond to the hormone progesterone. Researchers track these variations to understand how subtle differences in our genetic code might influence biological processes or susceptibility to certain health conditions. Because rs500760 is located in a gene critical for reproductive health, it has been a subject of interest in studies investigating conditions that affect the female reproductive system, such as endometriosis.
The Role of the PGR Gene
The PGR gene is responsible for producing the progesterone receptor, a protein that acts as a nuclear steroid hormone receptor. Progesterone is a vital hormone that plays a central role in the female reproductive cycle, including the establishment and maintenance of pregnancy. The receptor works by binding to progesterone and then interacting with DNA to regulate the expression of various genes involved in cellular growth, differentiation, and reproductive function. Because the progesterone receptor is essential for the normal physiological response to progesterone, variations in the PGR gene can theoretically alter how tissues in the uterus and other reproductive organs respond to hormonal signals. Understanding the function of this gene is key to interpreting why certain variants might be linked to reproductive health outcomes.
Research and Evidence
Scientific research has investigated the potential link between rs500760 and endometriosis, a condition where tissue similar to the lining of the uterus grows outside of it. Studies have examined whether this variant acts as a marker for increased risk in reproductive-age women. While some published research has explored this association, the evidence is considered moderate. Genetic associations are often complex, and findings can vary based on the population studied, sample sizes, and the specific methodology used. It is important to note that having a specific genotype does not guarantee the development of a condition; rather, it represents a statistical observation within a population. Current research continues to integrate genomic data to better understand the multifactorial nature of endometriosis, which involves both genetic predispositions and environmental factors.
Population Frequency
The rs500760 variant is considered a common SNP, meaning it is frequently observed across various human populations. Genetic databases indicate that the different alleles for this variant appear with enough regularity that it is not considered a rare mutation. Because it is common, researchers have been able to include it in large-scale studies to assess its frequency and potential impact across diverse ancestral backgrounds. While the specific distribution of the A and G alleles may fluctuate between different ethnic groups, the variant remains a standard point of analysis in reproductive genomics.
Interpreting Your Genetic Information
If you have information about your rs500760 genotype, it is important to view it in the proper context. This variant is a subject of scientific study and is not a diagnostic tool for endometriosis or any other medical condition. Genetic markers provide only a small piece of a much larger puzzle that includes your personal health history, lifestyle, and other environmental factors. You cannot use this information to diagnose yourself or predict future health outcomes with certainty. If you have concerns about reproductive health, symptoms of endometriosis, or questions about how your genetics might influence your health, please consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your results in the context of your overall health and provide appropriate medical guidance.
How common is this variant?
The rs500760 variant is a common genetic polymorphism found across diverse human populations.
Frequently asked questions
Does having the rs500760 variant mean I have endometriosis?
No. This variant is a statistical marker studied in the context of risk, not a diagnostic test. Many people carry this variant without ever developing endometriosis.
Can I use this SNP to predict my risk of reproductive issues?
Genetic variants like rs500760 provide only a small amount of information regarding health risk. You should not use this data to predict your personal health outcomes or replace professional medical advice.
Where can I find more information about the PGR gene?
You can find authoritative information about the PGR gene and its functions on resources like MedlinePlus Genetics or the NCBI Gene database. These sites provide detailed summaries of gene function and associated conditions.
Should I share my rs500760 results with my doctor?
If you are concerned about your reproductive health, you can share any genetic information you have with your doctor. However, they will likely focus on your clinical symptoms and medical history to provide care.
Sources & further reading
Educational information only, last refreshed 9/19/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs500760?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29