CDH18 rs555991893: What Your Genotype Means
This article explores the genetic variant rs555991893 located within the CDH18 gene. Current catalogs associate this specific single-nucleotide polymorphism with the clinical presentation of paralytic ileus, though evidence for this link remains moderate.
What each genotype means
Typical genetic profile
This genotype represents the most common genetic sequence observed at this location in the CDH18 gene. Research indicates that this variant is associated with the clinical presentation of paralytic ileus, but having the common sequence does not imply an increased risk for this condition. Please consult with your healthcare provider if you have specific concerns regarding your digestive health.
This is the most common genotype found across all major global populations.
Variant carrier status
You carry one copy of the genetic variant associated with the clinical presentation of paralytic ileus in the CDH18 gene. While this variant has been identified in research studies as having a statistical association with this condition, it is considered a rare finding. This result does not constitute a diagnosis, and you should discuss any symptoms or health concerns with your clinician.
This genotype is rare and observed at very low frequencies across global populations.
Rare variant homozygous
You carry two copies of the genetic variant associated with the clinical presentation of paralytic ileus in the CDH18 gene. This specific variant is rare, and its presence is noted in research regarding gastrointestinal health. Because this is a complex trait, this finding does not guarantee the development of any condition; please discuss this result with your doctor to understand its relevance to your personal health history.
This genotype is extremely rare and is found in a very small fraction of the population.
Understanding rs555991893 and CDH18
A single-nucleotide polymorphism, or SNP, is the most common type of genetic variation in humans, representing a difference in a single letter of the DNA code. The variant rs555991893 is positioned within the CDH18 gene, which provides instructions for making Cadherin-18. Cadherins are a family of proteins that act as molecular glue, facilitating calcium-dependent cell-to-cell adhesion. Cadherin-18 is primarily expressed in the central nervous system, where it is thought to play vital roles in how neurons connect, communicate, and navigate during development. Because this protein helps maintain the structural integrity and identity of cells, variations in the gene could theoretically influence pathways related to nerve signaling or cell development. While much of the research on CDH18 focuses on its role in brain development and its function as a potential tumor suppressor in certain cancers, its presence in other tissues continues to be a subject of scientific inquiry.
Research and Associations
The association between rs555991893 and paralytic ileus—a condition where the bowel loses its ability to contract and move contents through the digestive tract—is categorized as having moderate evidence. In genomic research, an association identifies a statistical correlation between a genetic variant and a trait; it does not automatically imply that the variant causes the condition. Many traits, especially those involving complex organ systems like the gut, are polygenic, meaning they are influenced by dozens or even hundreds of genetic markers, along with environmental factors. Because evidence is currently moderate, researchers are still working to determine whether this variant directly influences intestinal motility or if it is simply a marker located near other functional elements that play a larger role. As with many rare variants, larger studies across diverse populations are needed to confirm the strength and biological mechanism of this association.
Navigating Your Genetic Information
If you have received results indicating you carry the rs555991893 variant, it is important to understand what this information does and does not mean. Genetic associations are population-level observations; they are tools for researchers, not diagnostic tools for individuals. You should view this as one small piece of a much larger biological puzzle. Keep track of your health and discuss any symptoms, such as persistent digestive issues, with your healthcare provider. Never use a SNP result to diagnose a medical condition or predict future health outcomes. Do not alter any prescribed medications or treatments based on a single SNP result. If you are concerned about your digestive health, please consult a gastroenterologist or your primary care clinician to discuss your symptoms and medical history.
How common is this variant?
The variant rs555991893 is classified as a rare variant in human populations, meaning the minor allele frequency is typically less than 1% across major global populations.
Frequently asked questions
Is this SNP a direct cause of paralytic ileus?
No. Current evidence for this association is moderate, and genetic associations do not confirm direct causation. Paralytic ileus is a complex condition often linked to surgery, medication, or underlying metabolic health.
Should I be worried if I have this variant?
No. Most genetic variants have little to no effect on your daily health. This variant is rare, and its presence does not guarantee any specific health outcome.
Can I take a test to see if I have this SNP?
While some direct-to-consumer genetic tests may include this SNP, it is not a standard clinical test. Results should always be interpreted in the context of your overall health by a professional.
Will this variant affect how I react to medication?
There is currently no evidence linking this specific variant to drug metabolism or efficacy. Always discuss your medications and any potential side effects with your doctor or pharmacist.
Sources & further reading
Educational information only, last refreshed 10/8/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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