IL18 rs5744292: what the research says
This variant interacts with sodium intake to influence blood pressure outcomes.
What each genotype means
Typical IL18 expression profile
This genotype is associated with standard IL-18 expression levels in many populations. Research suggests this variant may interact with dietary sodium intake to influence blood pressure, though the evidence for this specific effect remains limited and requires further study.
This is a common genotype found across many global populations, though exact frequencies vary significantly by ancestry.
Typical IL18 expression profile
Carriers of this genotype possess one copy of each allele. Studies indicate that this variant may play a role in how your body responds to dietary sodium regarding blood pressure regulation, but current scientific evidence is limited and not definitive.
This heterozygous genotype is frequently observed in diverse populations worldwide.
Potential altered expression profile
This genotype has been studied in the context of IL-18 gene expression and its potential interaction with dietary sodium and blood pressure outcomes. Because the evidence linking this variant to health outcomes is limited, it is not a diagnostic marker; please discuss any concerns about blood pressure or diet with your healthcare provider.
This genotype is present in many populations, with frequency distributions that differ based on ancestral background.
Varies by ancestry
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A promoter variant (-137G/C) in the interleukin-18 gene that influences promoter transcriptional activity and circulating levels of pro-inflammatory IL-18.
Variant in the interleukin-18 gene associated with susceptibility to atopic dermatitis and allergic sensitization.
