F5 rs5929: Understanding Variations in Blood Clotting Factor V
The rs5929 variant is a genetic marker located within the F5 gene, which provides instructions for producing coagulation factor V. This variant is commonly observed in the population and is associated with variations in the levels of this essential blood-clotting protein.
What each genotype means
Typical factor V levels
This genotype represents the most common genetic configuration for this variant in the general population. Research indicates this variant is associated with variations in blood clotting factor V levels, but this specific genotype is not linked to clinical abnormalities. Please consult with a healthcare provider if you have concerns regarding your blood clotting profile.
This is the most common genotype observed across most global populations.
Varied factor V association
Carrying one copy of the G allele means you have a variation that has been associated with differences in blood clotting factor V levels. The clinical significance of this association is considered moderate, and it does not necessarily indicate a health condition. Discuss any concerns about your coagulation status or family history of clotting with your clinician.
This genotype is found at varying frequencies depending on ancestral background, appearing in a significant portion of the population.
Varied factor V association
Carrying two copies of the G allele is associated with variations in blood clotting factor V levels. While this variant is studied in the context of coagulation, it is not a diagnostic marker for disease. You should discuss your overall health and any relevant family history with a medical professional to understand what this means for your personal health profile.
This genotype is less common than the AA genotype but is present in the general population.
What is rs5929 and Where is it Located?
The variant rs5929 is a single nucleotide polymorphism (SNP) situated within the F5 gene. In genomics, a SNP represents a variation at a single position in the DNA sequence among individuals. The F5 gene is located on the long arm of chromosome 1. Because rs5929 is a common variant, it is frequently studied in the context of how genetic differences influence the production and regulation of proteins involved in the body's complex coagulation system. By analyzing such variants, researchers aim to understand the genetic architecture that contributes to the natural diversity of blood-related traits observed across different human populations.
The Role of the F5 Gene
The F5 gene is responsible for encoding coagulation factor V, a protein that plays a critical role in the blood coagulation cascade. This cascade is a series of chemical reactions that result in the formation of blood clots, which are necessary to stop bleeding after an injury and to initiate the repair of damaged blood vessels. Factor V circulates in the plasma and, when activated by thrombin, acts as a vital cofactor that helps convert prothrombin into thrombin. This process is essential for the stabilization of clots. Because of its central role in hemostasis, variations in the F5 gene can influence the efficiency of the clotting process, potentially impacting how an individual's blood responds to injury or stress.
Research Associations and Evidence Strength
The association between rs5929 and blood clotting factor V levels is supported by moderate evidence within the scientific literature. While the F5 gene is well-known for harboring pathogenic variants—such as the factor V Leiden mutation (rs6025) which is strongly linked to thrombophilia—rs5929 is primarily recognized for its association with quantitative variations in factor V levels. Current research, including data from large-scale genome-wide association studies (GWAS), highlights the role of various F5 variants in modulating hematological phenotypes. It is important to note that while statistical associations exist, the clinical significance of rs5929 in isolation is distinct from the high-risk variants that cause clinical clotting disorders. Researchers continue to investigate how these common variants interact with other genetic and environmental factors to influence overall cardiovascular and hematological health.
Population Frequency
The rs5929 variant is considered a common genetic marker. Its frequency varies across different ancestral groups, which is a standard observation for many common SNPs. Because it is widespread, it is frequently included in genetic studies to help map the landscape of human genetic diversity. Understanding the frequency of such variants helps scientists distinguish between rare, high-impact mutations and common variations that contribute to the normal range of physiological traits. There is no evidence to suggest that this specific variant is restricted to any single population, and it is routinely identified in diverse cohorts participating in genomic research.
Interpreting Your Genetic Information
Information regarding common variants like rs5929 is intended for educational purposes to help you understand the biological basis of human traits. It is crucial to recognize that a genetic association is not a medical diagnosis. Many factors, including lifestyle, diet, and other genetic markers, influence blood clotting and overall health. If you have concerns about your blood clotting profile, family history of thrombosis, or any other medical condition, you should consult with a qualified healthcare provider or a genetic counselor. They can provide context based on your personal health history and clinical testing. Never use information from genetic databases to make decisions about medications or medical treatments without professional guidance.
How common is this variant?
The rs5929 variant is common across diverse human populations, with its specific allele frequencies varying by ancestry.
Frequently asked questions
Is rs5929 the same as factor V Leiden?
No, rs5929 is a different variant from the factor V Leiden mutation (rs6025). Factor V Leiden is a well-characterized mutation associated with an increased risk of blood clots, whereas rs5929 is primarily associated with variations in factor V levels.
Does having this variant mean I have a clotting disorder?
No, having a specific genotype for a common variant like rs5929 does not constitute a diagnosis of a clotting disorder. Genetic associations describe statistical trends in populations rather than individual medical outcomes.
Should I get tested for this variant?
Genetic testing for common variants is generally not recommended for clinical decision-making unless there is a specific medical reason identified by your doctor. If you are concerned about your risk for blood clots, consult a healthcare professional about appropriate clinical screening.
Can I change my risk based on this genotype?
Genetic variants are inherited and cannot be changed. However, you can manage your overall health through lifestyle choices such as maintaining a healthy weight, staying active, and avoiding smoking, which are known to influence cardiovascular health.
Sources & further reading
Educational information only, last refreshed 10/7/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs5929?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29