CCND1 rs602652: Understanding This Genetic Variant
The rs602652 variant is a single-nucleotide polymorphism located within the CCND1 gene. It has been investigated in scientific literature for its potential association with the risk of developing invasive epithelial ovarian cancer.
What each genotype means
Common variant genotype
This genotype represents one of the common variations in the CCND1 gene. Research has investigated this variant for potential associations with the risk of certain cancers, including invasive epithelial ovarian cancer, though evidence remains limited and findings are not definitive.
This genotype is common, with the A allele appearing at a frequency of approximately 48.6% in global populations.
Common variant genotype
This genotype represents a heterozygous state for this CCND1 variant. While this gene is a known oncogene involved in cell cycle regulation, current scientific literature does not establish this specific genotype as a reliable predictor of disease risk for individuals.
This genotype is common, occurring frequently across diverse ancestral populations.
Common variant genotype
This genotype represents the alternative homozygous state for this CCND1 variant. Studies exploring this variant in the context of ovarian and other cancers have yielded mixed results, and it is not currently used as a clinical marker for risk assessment.
This genotype is common, appearing in a significant portion of the general population.
What is rs602652?
The variant rs602652 is a specific change in the DNA sequence, known as a single-nucleotide polymorphism or SNP, located on chromosome 11. In the human genome, this position is identified by its reference SNP ID (rsID) and sits within the CCND1 gene. Genetic variants like rs602652 represent common differences in the DNA code between individuals. While many such variants have no observable effect on health, researchers study them to determine if they influence biological processes or contribute to disease susceptibility. This particular variant is categorized as a reproductive-related marker in some genetic databases due to its inclusion in studies examining cancer risk factors.
The Role of the CCND1 Gene
The CCND1 gene provides instructions for making a protein called cyclin D1. This protein plays a critical role in the cell cycle, which is the process by which cells grow and divide. Cyclin D1 acts as a regulator, helping the cell transition from the growth phase into the DNA synthesis phase. Because of its central role in controlling cell division, the CCND1 gene is often studied in the context of oncology. When the regulation of the cell cycle is disrupted, it can potentially lead to uncontrolled cell growth. Researchers investigate variants within this gene to see if they might alter the expression or function of the cyclin D1 protein, thereby influencing the risk of various conditions.
Research and Evidence Strength
The evidence linking rs602652 to health outcomes is currently considered limited. While some candidate gene studies have explored the relationship between common variants in cell cycle genes and the risk of invasive epithelial ovarian cancer, the findings are not definitive. Scientific research often involves large-scale association studies to determine if a specific genotype occurs more frequently in individuals with a particular condition compared to the general population. For rs602652, the associations reported in the literature have not reached the level of clinical consensus required to use this variant as a predictive tool. It is important to recognize that genetic associations are statistical in nature and do not imply a direct cause-and-effect relationship.
Understanding Your Information
If you have received information about your genotype for rs602652, it is essential to view it within the context of current scientific understanding. This variant is not a diagnostic marker, and having a specific genotype does not mean you will develop any particular condition. Genetic risk is complex and typically involves the interaction of many different genes, environmental factors, and lifestyle choices. You cannot use this information to make medical decisions or predict future health outcomes. If you have concerns about your personal or family health history, particularly regarding ovarian cancer or other reproductive health issues, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor who can provide personalized guidance.
How common is this variant?
The rs602652 variant is a common polymorphism with a global minor allele frequency reported at approximately 0.4858 in some databases, indicating that both alleles are widely distributed across various ancestral populations.
Frequently asked questions
Is rs602652 a diagnostic test for ovarian cancer?
No, rs602652 is not a diagnostic test. It is a genetic variant that has been studied for potential statistical associations with cancer risk, but it cannot be used to diagnose or predict the development of ovarian cancer.
Should I be worried if I have the C/C genotype?
No, you should not be worried. The genotypes for this variant are common in the general population and are not considered indicators of disease on their own.
Where can I find more information about CCND1?
You can find reliable information about the CCND1 gene and its function in the cell cycle through resources like MedlinePlus Genetics or the National Center for Biotechnology Information (NCBI) Gene database.
Does this variant affect how I should manage my health?
No, this variant does not provide actionable medical information. You should continue to follow standard health screening guidelines recommended by your doctor based on your age, family history, and other personal health factors.
Sources & further reading
Educational information only, last refreshed 10/13/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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