AR rs6113491: What Your Genotype Means
The rs6113491 variant is a single-nucleotide polymorphism located within the androgen receptor (AR) gene. It has been identified in research as being associated with the development of hereditary male pattern baldness.
What each genotype means
Typical androgen receptor variant
This genotype is associated with the androgen receptor locus, which has been linked to hereditary male pattern baldness in large-scale genetic studies. Because this is a complex trait influenced by many genetic and environmental factors, this genotype alone does not determine your hair loss risk. Please note that the evidence linking this specific variant to baldness is considered limited in its predictive power.
This genotype is common in populations of European ancestry, where the minor allele frequency for this variant is approximately 0.38.
Typical androgen receptor variant
This genotype is associated with the androgen receptor locus, which has been linked to hereditary male pattern baldness in large-scale genetic studies. Because this is a complex trait influenced by many genetic and environmental factors, this genotype alone does not determine your hair loss risk. Please note that the evidence linking this specific variant to baldness is considered limited in its predictive power.
This genotype is common in populations of European ancestry, where the minor allele frequency for this variant is approximately 0.38.
Typical androgen receptor variant
This genotype is associated with the androgen receptor locus, which has been linked to hereditary male pattern baldness in large-scale genetic studies. Because this is a complex trait influenced by many genetic and environmental factors, this genotype alone does not determine your hair loss risk. Please note that the evidence linking this specific variant to baldness is considered limited in its predictive power.
This genotype is common in populations of European ancestry, where the minor allele frequency for this variant is approximately 0.38.
Understanding the Variant and Its Location
The variant rs6113491 is a specific change in the DNA sequence located within the androgen receptor (AR) gene. In genomics, a single-nucleotide polymorphism (SNP) represents a variation at a single position in the DNA chain. The AR gene is situated on the X chromosome, which is significant because men possess only one X chromosome, making them particularly sensitive to variations in genes located there. This specific SNP is classified as an intronic variant, meaning it resides in a non-coding region of the gene. While it does not directly alter the protein sequence of the androgen receptor, such variants can influence how the gene is regulated, expressed, or spliced within the body. Researchers study these locations to understand how subtle changes in our genetic code contribute to observable physical traits.
The Role of the Androgen Receptor Gene
The AR gene provides instructions for making a protein called the androgen receptor. This receptor allows the body to respond to androgens, which are hormones like testosterone and dihydrotestosterone (DHT) that play a critical role in male sexual development and various physiological processes. In the context of hair follicles, androgen receptors are involved in the signaling pathways that regulate the hair growth cycle. When these receptors are highly sensitive or over-activated in the scalp, it can lead to the miniaturization of hair follicles, a hallmark of androgenetic alopecia, commonly known as male pattern baldness. Because the AR gene is a central player in this hormonal pathway, variations within or near this gene are frequently investigated to determine how they might influence the timing or severity of hair loss in men.
Research and Evidence Strength
Scientific research has established a strong link between the androgen receptor locus and male pattern baldness. Large-scale genome-wide association studies (GWAS) have consistently identified the AR region as a major determinant of this trait. While rs6113491 is recognized as a marker within this locus, it is important to note that the evidence strength for this specific SNP is considered limited in terms of its individual predictive power. Genetic traits like baldness are polygenic, meaning they are influenced by many different variants across the genome, not just one. While the AR gene is a primary driver, the actual risk for an individual is the result of a complex interplay between numerous genetic factors and environmental influences. Current research continues to refine our understanding of how these specific variants contribute to the overall genetic architecture of hair loss.
Population Frequency and Distribution
Genetic variants are not distributed equally across all human populations. For the rs6113491 variant, data indicates an allele frequency of approximately 0.38 in individuals of European ancestry. This means that the variant is relatively common in this population group. Frequency can vary significantly when comparing different global ancestries, which is a standard observation in human genetics. Understanding these frequencies helps researchers determine if a variant is a rare mutation or a common polymorphism that has persisted in the population over time. Because this variant is common, it is considered a normal part of human genetic diversity rather than a rare disease-causing mutation. However, its prevalence does not necessarily dictate the severity of the trait in any single individual, as other genetic and non-genetic factors are also at play.
Interpreting Your Genetic Information
If you have access to your genetic data, you may see information regarding your genotype for rs6113491. It is essential to remember that this information is for educational purposes and does not constitute a medical diagnosis. Genetic associations are statistical observations made across large groups of people and cannot predict an individual's future with certainty. Many factors, including age, hormonal balance, and overall health, influence the expression of traits like hair loss. You cannot change your genotype, but understanding your genetic predispositions can be a starting point for conversations with a healthcare professional. If you are concerned about hair loss or any other health-related trait, consult a dermatologist or a qualified clinician. They can provide personalized advice based on your clinical history rather than relying on genetic data alone.
How common is this variant?
The rs6113491 variant has an allele frequency of approximately 0.38 in populations of European ancestry.
Frequently asked questions
Is rs6113491 a direct cause of baldness?
No, rs6113491 is a genetic marker associated with the trait. It is not a direct cause, as hair loss is a complex condition influenced by many genes and environmental factors.
Can I use this SNP to predict if I will go bald?
Genetic markers provide statistical probabilities rather than definitive predictions. Because many genes contribute to hair loss, a single SNP cannot accurately predict your personal outcome.
Does this variant affect how I should treat hair loss?
This variant does not provide information on how you should treat hair loss. Always discuss any concerns about hair loss treatments with a qualified dermatologist or clinician.
Why is the AR gene important for hair loss?
The AR gene encodes the androgen receptor, which mediates the effects of hormones like testosterone. These hormones are known to play a key role in the biological pathways that lead to hair follicle miniaturization.
Sources & further reading
Educational information only, last refreshed 9/21/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Androgen receptor locus variant on chromosome X strongly associated with early-onset androgenetic alopecia (male pattern baldness).
This variant in the androgen receptor gene is associated with androgen insensitivity and has been linked to variations in human adult height.
Pathogenic substitution in the androgen receptor gene leading to partial or complete androgen insensitivity syndrome and male infertility.
Androgen receptor variant associated with male-pattern (androgenetic) hair loss.
Point mutation in AR causing mild androgen insensitivity syndrome, presenting with impaired spermatogenesis and male infertility.
Pathogenic substitution in the hormone-binding domain of the androgen receptor leading to complete androgen insensitivity syndrome.