OR11H7P rs670017: What Your Genotype Means for Asparagus Smell
The rs670017 variant is a genetic marker located near the OR11H7P gene, which is involved in the olfactory system. Research suggests this variant is associated with differences in the ability to detect the characteristic odor of asparagus metabolites in urine.
What each genotype means
Typical asparagus odor perception
This genotype is associated with the ability to detect the characteristic sulfurous metabolites in urine after consuming asparagus. Research indicates that genetic variation near olfactory receptor loci influences this sensory perception, though individual experiences may still vary.
This genotype is common in many populations, though exact frequencies vary by ancestry.
Typical asparagus odor perception
Individuals with this genotype generally possess the olfactory receptors necessary to detect asparagus metabolites in urine. This trait is part of a broader spectrum of human sensory variation linked to olfactory receptor gene clusters.
This heterozygous genotype is frequently observed in populations where the minor allele frequency is approximately 0.35.
Potential asparagus anosmia
This genotype is associated with a reduced ability to detect the specific odor of asparagus metabolites in urine, a condition sometimes referred to as asparagus anosmia. This is a sensory variation related to olfactory receptor function rather than a medical condition.
Carried by a significant portion of the population, with the minor allele frequency estimated at approximately 0.35 in European populations.
Understanding the rs670017 Variant
The rs670017 variant is a single nucleotide polymorphism (SNP) situated in the human genome near the OR11H7P locus. In genetics, a SNP represents a variation at a single position in a DNA sequence among individuals. This specific variant is located in a region associated with olfactory receptor genes, which are responsible for our sense of smell. Because this region contains pseudogenes—sequences that resemble functional genes but may not produce a working protein—it is a subject of interest for researchers studying sensory perception. The variant serves as a genetic tag that researchers use to investigate why some people can detect specific odors while others cannot. It is important to note that while this SNP is statistically associated with certain sensory traits, it does not function as a diagnostic tool for any medical condition.
The Role of Olfactory Receptor Genes
The OR11H7P gene is part of the olfactory receptor family, a large group of G protein-coupled receptors that detect odorant molecules. These receptors are located on the surface of olfactory sensory neurons in the nose. When an odorant molecule binds to a receptor, it initiates a signal transduction pathway that sends information to the brain, allowing us to perceive a smell. Some genes in this family are classified as pseudogenes, meaning they may have lost their ability to encode a functional protein over the course of evolution. The variation near OR11H7P is particularly interesting because it highlights how subtle genetic differences can influence the sensitivity of our olfactory system. By studying these receptors, scientists gain insight into the biological mechanisms that underlie the vast diversity of human odor perception.
Research on Asparagus Anosmia
Scientific research has identified a link between genetic variation in olfactory receptor regions and the phenomenon known as 'asparagus anosmia.' This term refers to the inability to detect the distinct, sulfurous odor of asparagus metabolites in urine after consumption. Genome-wide association studies have pointed to variants near olfactory receptor genes, including the region containing rs670017, as potential contributors to this sensory difference. The evidence for this association is considered limited, as olfactory perception is a complex trait influenced by multiple genetic and environmental factors. While the statistical correlation is documented in scientific literature, it is not a definitive predictor of an individual's sensory experience. Further research is required to fully understand the functional impact of this specific variant on the olfactory receptors involved in detecting these particular chemical compounds.
Population Frequency and Interpretation
The rs670017 variant is relatively common, with a minor allele frequency of approximately 0.35 in European populations. This means that a significant portion of the population carries the variant, reflecting the natural genetic diversity found in humans. When interpreting this information, it is essential to understand that genetic associations are based on population-level data and do not necessarily apply to every individual in the same way. Because the evidence linking this variant to specific sensory traits is limited, individuals should view this information as an educational insight into human biology rather than a clinical finding. There is no medical action required or recommended based on this genotype. If you have concerns about your sensory perception or any other health-related issues, it is always best to consult with a qualified healthcare professional.
How common is this variant?
The rs670017 variant has a minor allele frequency of approximately 0.35 in European populations, indicating it is a common genetic variation.
Frequently asked questions
What is asparagus anosmia?
Asparagus anosmia is the inability to smell the characteristic sulfurous odor produced in urine after eating asparagus. It is a common sensory trait that varies significantly between individuals.
Does my genotype mean I cannot smell asparagus?
Not necessarily. While this variant is associated with the trait, olfactory perception is complex and influenced by many genes and environmental factors. A genetic test result is not a definitive diagnostic tool for your personal sensory abilities.
Is this variant related to a medical condition?
No, this variant is associated with a sensory trait related to odor perception. It is not linked to any known medical disease or health condition.
Should I be concerned about my rs670017 result?
There is no reason for concern. This variant is a normal part of human genetic variation and relates to how you perceive certain smells, which is a standard aspect of human biological diversity.
Sources & further reading
Educational information only, last refreshed 9/24/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Variant in an olfactory receptor gene cluster strongly associated with the specific ability to smell or detect the distinct odor of asparagus urinary metabolites.
Associated with specific olfactory detection thresholds for isovaleric acid, an odorant typical of sweat and stinky cheese.
Variant strongly associated with the ability to perceive the distinctive odor of asparagus metabolites in urine (asparagus anosmia).