PAM rs6889592: what the research says
This variant in the PAM gene is associated with an increased risk of type 2 diabetes mellitus, with specific associations observed in females and individuals with lower BMI.
What each genotype means
Typical PAM activity
This is the most common genotype for this variant. Research indicates that individuals with this genotype do not carry the specific genetic marker associated with the increased risk of type 2 diabetes observed in some populations for this variant.
This is the major allele genotype and is the most common form found across global populations.
Increased diabetes risk marker
Carrying one copy of the A allele is associated with an increased risk of type 2 diabetes in certain populations, particularly in females and individuals with a lower BMI. This association is based on limited evidence and does not mean you will develop the condition; it is one of many factors that influence metabolic health.
The frequency of this genotype varies significantly by ancestry, appearing more frequently in some Asian populations compared to others.
Increased diabetes risk marker
Carrying two copies of the A allele is associated with an increased risk of type 2 diabetes in certain populations, with specific associations noted in females and individuals with a lower BMI. This finding is based on limited evidence and should be viewed as a statistical association rather than a diagnostic indicator. Please discuss your overall metabolic health and any concerns about diabetes risk with your healthcare provider.
This genotype is less common than the GG or GA genotypes and its prevalence varies by ancestral background.
Varies by population
Curious what your genotype is for rs6889592?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants in PAM
This variant in the PAM gene is linked to an increased risk of type 2 diabetes mellitus, particularly in patients without retinopathy.
This variant in the PAM gene is associated with an increased risk of type 2 diabetes mellitus in the Chinese population.