MYC rs6984305: Understanding This Genetic Variant
The rs6984305 variant is a single-nucleotide polymorphism located in a regulatory region near the MYC gene. It has been identified in scientific studies as being associated with an increased risk of developing certain types of cancer, including colorectal and prostate cancers.
What each genotype means
Baseline risk profile
This genotype represents the more common version of this variant in many populations. Research indicates that individuals with this genotype do not carry the specific allele associated with the increased risk of colorectal and prostate cancers observed in some studies. Please note that cancer risk is complex and influenced by many genetic and environmental factors.
This is the major allele genotype and is common across most global populations.
Slightly elevated risk profile
This genotype includes one copy of the risk-associated allele. Some studies have linked this variant to a statistically higher risk of developing colorectal and prostate cancers, though the individual impact is considered modest. Because this is a complex trait, this result should not be viewed as a diagnosis; discuss your overall health and family history with a healthcare provider.
This heterozygous genotype is found in a significant portion of the population, with the minor allele frequency reported around 11% in some datasets.
Increased risk profile
This genotype contains two copies of the allele associated with a higher statistical risk for colorectal and prostate cancers in various genome-wide association studies. While this association is documented, the actual risk for any one person remains influenced by a wide range of other genetic and lifestyle factors. You should consult with a medical professional to discuss appropriate screening and preventative health strategies based on your full clinical profile.
This homozygous genotype is less common than the others, occurring in a smaller percentage of the general population.
What is rs6984305?
A single-nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs6984305 is located on chromosome 8. In the context of human genetics, this specific location is situated within a regulatory region of the genome. Regulatory regions are segments of DNA that do not code for proteins themselves but instead act as switches or control centers that determine when and how much of a nearby gene is expressed. Because rs6984305 sits in such a region, researchers study it to understand if it influences the activity of neighboring genes, potentially altering biological processes that contribute to disease susceptibility.
The Role of the MYC Gene
The MYC gene is a well-known proto-oncogene that plays a critical role in the cell cycle, cell growth, and apoptosis, which is the process of programmed cell death. Under normal conditions, MYC helps regulate healthy cell division. However, when the expression of MYC is dysregulated or amplified, it can lead to uncontrolled cell proliferation, a hallmark of cancer development. Because rs6984305 is located in a regulatory area near MYC, scientists hypothesize that this variant may influence the expression levels of the MYC protein. By modulating how much MYC is produced, the variant might indirectly affect the stability and growth patterns of cells, which is why it is a subject of interest in oncology research.
Research and Evidence Strength
The association between rs6984305 and cancer risk has been observed primarily through genome-wide association studies (GWAS). These studies compare the DNA of individuals with a specific condition to those without it to find statistical correlations. Research has linked this variant to a higher risk of colorectal and prostate cancers. However, it is important to note that the evidence strength for this association is considered limited. While a statistical correlation exists, the biological mechanism—exactly how this specific SNP changes cancer risk—is complex and not fully understood. Furthermore, genetic risk is only one piece of a much larger puzzle; environmental factors, lifestyle, and other genetic variants all contribute to an individual's overall health profile.
Population Frequency
The rs6984305 variant is considered a common SNP in human populations. Genetic variants that are common are found in a significant percentage of the general population, rather than being rare mutations restricted to specific families or groups. Because it is common, many people carry one or two copies of the variant without ever developing the associated conditions. Frequency can vary across different ancestral backgrounds, and researchers continue to study these differences to understand how genetic architecture differs globally. Having a common variant does not mean an individual will develop a disease; it simply means the variant is a frequent feature of the human genetic landscape.
Interpreting Your Genetic Information
If you have received information about your rs6984305 status, it is essential to view it in the proper context. This variant is a statistical marker, not a diagnostic tool. It cannot predict with certainty whether you will or will not develop cancer. Many factors, including family history, age, diet, and environmental exposures, play a much larger role in cancer risk than any single SNP. You cannot 'change' your genotype, but you can focus on evidence-based health practices, such as regular screenings and maintaining a healthy lifestyle. If you are concerned about your genetic risk for cancer, the most appropriate step is to consult with a genetic counselor or a healthcare professional who can interpret your results alongside your personal and family medical history.
How common is this variant?
The rs6984305 variant is common across diverse human populations, with a Global Minor Allele Frequency (GMAF) reported at approximately 0.114 in some databases.
Frequently asked questions
Does having the rs6984305 variant mean I will get cancer?
No. This variant is only associated with a statistical increase in risk, not a diagnosis. Most people who carry this variant will never develop cancer, as many other factors contribute to disease risk.
What should I do if I have the risk-associated genotype?
You should continue to follow standard medical guidelines for cancer screening appropriate for your age and gender. Discuss your family history and any concerns with your primary care physician or a genetic counselor.
Is rs6984305 a mutation?
In genetics, the term 'variant' is preferred for common differences in DNA sequence. While it is a change from the reference sequence, it is a common variation found in the general population rather than a rare, disease-causing mutation.
Can I change my genotype for rs6984305?
No, your genotype is determined at conception and cannot be changed. However, you can manage your overall health through lifestyle choices and regular medical check-ups.
Sources & further reading
Educational information only, last refreshed 9/23/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This non-coding variant on chromosome 8q24 near the MYC proto-oncogene is significantly associated with an increased susceptibility to bladder cancer.
This variant is located in a gene desert near the MYC oncogene and is associated with an increased risk of colorectal and prostate cancers.
This variant is a well-established risk factor for colorectal and prostate cancer susceptibility.