REL rs702873: Understanding Your Genetic Link to Psoriasis
The rs702873 variant is a common genetic change located in the REL gene, which plays a critical role in immune system regulation. Research has repeatedly linked this variant to an increased risk of developing psoriasis, a chronic inflammatory skin condition.
What each genotype means
Typical risk profile
This genotype is considered the baseline for this variant in many populations. Research indicates that individuals with this genotype do not carry the specific genetic variation associated with increased psoriasis susceptibility at this location.
This is a common genotype found in many populations, though exact frequencies vary by ancestry.
Slightly increased risk
Carrying one copy of the T allele is associated with a statistically higher risk of developing psoriasis compared to those without it. This variant is thought to influence the REL gene, potentially leading to increased c-Rel protein expression and enhanced inflammatory signaling, though the exact mechanism remains under investigation.
This genotype is common, appearing in a significant portion of individuals of European and Asian ancestry.
Increased risk profile
Carrying two copies of the T allele is associated with an increased susceptibility to psoriasis in several studies. This genetic profile may contribute to overactive immune responses through the NF-κB signaling pathway, which is a known factor in the development of psoriatic inflammation.
This genotype is observed across various populations, though it is less frequent than the heterozygous state in many cohorts.
What is rs702873?
The variant rs702873 is a single-nucleotide polymorphism (SNP) located within the REL gene region on chromosome 2. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is frequently studied in the context of autoimmune and inflammatory conditions. Because it is a common variant, it is found in a significant portion of the general population across various ancestries. Scientists track such variants to understand how subtle differences in our genetic code can influence the way our bodies respond to environmental triggers and regulate internal processes, such as inflammation.
The Role of the REL Gene
The REL gene provides instructions for making a protein called c-Rel, which is a member of the NF-κB family of transcription factors. These proteins act as master switches in the immune system, controlling the expression of genes involved in inflammation and cell survival. Specifically, c-Rel is essential for the proper function of immune cells, including T cells and dendritic cells. When the NF-κB signaling pathway is overactive or dysregulated, it can lead to chronic inflammation. Because c-Rel is a key component of this pathway, variations in the REL gene can influence how strongly the immune system reacts, potentially contributing to the development of inflammatory diseases like psoriasis.
Research and Psoriasis Association
Multiple genome-wide association studies (GWAS) have identified rs702873 as a susceptibility locus for psoriasis. The evidence for this association is considered moderate to strong, as it has been replicated across various European and Asian cohorts. Research suggests that the risk-associated allele may lead to enhanced expression or activity of the c-Rel protein, which in turn promotes the inflammatory loops characteristic of psoriasis. While the link to psoriasis is well-documented, it is important to note that having this variant does not guarantee the development of the condition. Psoriasis is a complex, multifactorial disease influenced by a combination of genetic, environmental, and lifestyle factors.
Population Frequency
The rs702873 variant is considered common in human populations. Studies have observed the variant across diverse ethnic groups, including European and Asian populations. While the frequency of the specific alleles (G and A) can vary by ancestry, the variant is widespread enough that it is frequently included in genetic risk scores for inflammatory conditions. Its prevalence makes it a useful marker for researchers studying the genetic architecture of autoimmune diseases, though its specific impact on disease risk can differ depending on the genetic background of the population being studied.
Interpreting Your Genetic Information
Understanding your genotype for rs702873 provides insight into your genetic predisposition, but it is not a diagnostic tool. Genetic variants are only one piece of a much larger puzzle that includes your environment, health history, and lifestyle. If you are concerned about psoriasis or other inflammatory conditions, this information should be discussed with a healthcare professional or a dermatologist. They can evaluate your symptoms and family history to provide appropriate medical guidance. Never use genetic data to make self-diagnosis or to alter medical treatments without consulting a qualified clinician.
How common is this variant?
The rs702873 variant is common across global populations, with both the G and A alleles appearing frequently in European and Asian cohorts.
Frequently asked questions
Does having the rs702873 variant mean I will get psoriasis?
No. Having this variant indicates a statistical association with an increased risk, but it does not cause the disease on its own. Psoriasis is complex and depends on many genetic and environmental factors.
What is the relationship between REL and NF-κB?
The REL gene encodes the c-Rel protein, which is a subunit of the NF-κB transcription factor complex. This complex is a primary regulator of immune responses and inflammation in the body.
Can I use this information to treat my skin condition?
No. Genetic information is for educational purposes only. You should always consult a dermatologist or healthcare provider to discuss any skin conditions and appropriate treatment plans.
Is rs702873 associated with other diseases?
While most strongly linked to psoriasis, researchers have investigated the REL gene in the context of other autoimmune conditions like rheumatoid arthritis and celiac disease. Results across different diseases and populations can be mixed.
Sources & further reading
Educational information only, last refreshed 10/29/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs702873?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29