rs7219932 and LOC130061867: Understanding This Genetic Variant
The genetic variant rs7219932 is a single nucleotide polymorphism (SNP) located within the genomic region identified as LOC130061867. It is currently classified in clinical databases as a benign regulatory locus, meaning it is not associated with any specific disease or clinical trait.
What each genotype means
Typical regulatory variant profile
This genotype represents the homozygous state for the variant. As this is an intronic variant located within a region identified as a silencer element, it is currently classified as a benign regulatory locus with no established clinical disease association.
Population frequency data for this specific genotype is not currently available in major public reference databases.
Typical regulatory variant profile
This genotype represents the heterozygous state for the variant. Current research characterizes this site as a benign regulatory locus, and there is no evidence suggesting this specific combination of alleles alters gene function in a clinically significant way.
Population frequency data for this specific genotype is not currently available in major public reference databases.
Typical regulatory variant profile
This genotype represents the homozygous state for the reference allele. This variant is annotated as a benign regulatory locus, and carrying this genotype is considered a standard variation within this non-coding genomic region.
Population frequency data for this specific genotype is not currently available in major public reference databases.
What is rs7219932 and Where is it Located?
A single nucleotide polymorphism, or SNP, represents a variation at a single position in the DNA sequence among individuals. The variant rs7219932 is situated within a genomic region designated by the NCBI Gene ID LOC130061867. In genomics, 'LOC' identifiers are assigned to regions of the genome that are not yet characterized as well-defined protein-coding genes but show evidence of regulatory activity, such as being identified as active regions in functional genomics studies. Because it is located in an intronic or regulatory region, this variant does not change the amino acid sequence of a protein directly; instead, it may influence the expression levels of nearby genes. Current evidence labels this variant as a benign regulatory locus, suggesting it is a normal part of human genetic diversity and does not disrupt standard biological functions.
The Role of LOC130061867
The region LOC130061867 is not a traditional gene with a known, singular biological function. In modern genomics, large-scale mapping projects frequently identify these 'LOC' regions during high-throughput sequencing experiments, such as those analyzing chromatin accessibility or regulatory potential. These regions often function as switches or enhancers that help turn other genes on or off in specific tissues or during specific developmental stages. Because the field is still learning about these non-coding segments of the genome, LOC130061867 is primarily categorized by its location and potential regulatory influence rather than a specific protein it encodes. Researchers view such loci as essential components of the genome's regulatory landscape, which orchestrates the complex activity of the thousands of genes that define human biology.
Research and Evidence Strength
The scientific evidence associating rs7219932 with any specific health outcome, trait, or disease is currently classified as moderate to non-existent in terms of clinical impact. While the variant appears in large genomic catalogs like dbSNP, it has not been linked to specific medical conditions in major peer-reviewed genome-wide association studies (GWAS). In clinical genetics, a 'benign' classification indicates that the variant is found in healthy populations and does not possess characteristics that would disrupt normal health or predispose an individual to disease. Because research is ongoing, scientific databases continue to monitor this site to ensure that any future evidence is captured. As of today, rs7219932 remains a neutral marker of genetic variation, serving as a reminder that the vast majority of variations in our DNA do not have a discernible effect on our daily health.
What You Can and Cannot Do With This Information
Because this variant is considered a benign regulatory locus and not a pathogenic or disease-causing mutation, it is important to remember that this information is intended for educational purposes only. You cannot use the presence of this variant to diagnose a medical condition or predict future health outcomes. If you have received a report mentioning this variant, there is generally no clinical action required, as it is considered part of normal human variation. Genetic tests often include a large number of SNPs to provide a comprehensive map of your genome, and variants like rs7219932 are often included because they are common landmarks in our DNA. Always consult with a healthcare professional or a board-certified genetic counselor if you have questions about specific entries in your genetic data.
How common is this variant?
Specific population frequency data for this variant is not provided in major public databases, as it is classified as a benign regulatory locus.
Frequently asked questions
Is rs7219932 a dangerous mutation?
No, rs7219932 is categorized as a benign regulatory locus. There is currently no evidence in scientific literature suggesting it is dangerous or associated with any disease.
Should I be worried if my report shows this variant?
No, you should not be worried. It is a normal variation found in human DNA and is documented in clinical databases as benign, meaning it is not a cause for medical concern.
Does this variant affect my response to medication?
There is no current evidence or clinical data suggesting that rs7219932 affects how your body processes or responds to any medications. Always discuss your medications and dosing with your clinician or pharmacist.
Why does my genetic report list this variant?
Genetic tests often include a large number of SNPs to provide a comprehensive map of your genome. Variants like rs7219932 are often included because they are common landmarks in our DNA, even if they do not have a known impact on health.
Sources & further reading
Educational information only, last refreshed 9/15/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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