FNDC5 rs726344: what the research says
This variant shows functional significance in luciferase activity assays, suggesting a role in regulating irisin levels relevant to metabolic health and aging.
What each genotype means
Typical irisin regulation
This genotype is the common variant and is not associated with the functional changes in irisin levels observed in laboratory assays. It represents the standard genetic background for this locus.
This is the most common genotype in the general population.
Possible metabolic regulation
This genotype has shown functional significance in laboratory assays, suggesting a potential role in regulating irisin levels. However, the clinical relevance of this finding for metabolic health in humans remains uncertain.
This genotype is found at variable frequencies across different populations.
Possible metabolic regulation
This genotype is associated with potential differences in irisin regulation based on functional studies. Because the evidence is limited to laboratory assays, it is unclear how this affects overall metabolic health.
This genotype is found at variable frequencies across different populations.
Variable
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