SLC2A9 rs736408: Understanding Your Genetic Risk for Gout
The rs736408 variant is a specific genetic change located within the SLC2A9 gene, which plays a critical role in how the body handles uric acid. Research has identified this variant as being associated with variations in serum uric acid levels and an increased risk of developing gout.
What each genotype means
Typical urate transport profile
This genotype represents the most common genetic configuration for this variant in many populations. Research indicates that individuals with this profile do not carry the specific genetic markers associated with the altered uric acid transport activity linked to the SLC2A9 gene. Please note that gout risk is multifactorial, involving diet, lifestyle, and other genetic factors beyond this single variant.
This is the most common genotype globally, found in the majority of the population.
Modified urate transport potential
Carrying one copy of the variant allele is associated with differences in how the kidneys handle uric acid, which can influence serum urate levels. Studies suggest that the impact of this variant on uric acid levels can be sex-specific, with some research showing more pronounced effects in women than in men. You should discuss your overall metabolic health and any concerns regarding uric acid levels with your healthcare provider.
This heterozygous genotype is common, appearing in a significant portion of the global population.
Increased urate transport sensitivity
Individuals with two copies of this variant allele may experience a more pronounced effect on serum uric acid concentrations compared to those with other genotypes. Because SLC2A9 acts as a high-capacity urate transporter, variations here can influence the risk of hyperuricemia and gout. As this is a complex trait, please consult with a clinician to interpret these findings in the context of your personal health history and blood test results.
This genotype is less common than the others, occurring in approximately 20% of the global population.
What is rs736408 and Where is it Located?
The rs736408 variant is a single nucleotide polymorphism (SNP) found within the SLC2A9 gene. This gene is located on chromosome 4 at position 4p16.1. In the context of human genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. The SLC2A9 gene provides instructions for making a protein known as GLUT9, which functions as a transporter. While the gene is primarily recognized for its role in transporting glucose and fructose, it has also been identified as a high-capacity transporter for uric acid. The specific location of rs736408 within this gene is significant because it sits in a region that influences how the body regulates the excretion and reabsorption of urate, the byproduct of purine metabolism.
The Role of the SLC2A9 Gene
The SLC2A9 gene encodes the GLUT9 protein, which is essential for maintaining the balance of uric acid in the blood. In humans, uric acid is the final product of purine breakdown. Unlike many other mammals, humans lack the enzyme uricase, which means we naturally maintain higher levels of serum uric acid. The kidneys are responsible for the majority of daily urate disposal. The GLUT9 protein acts as a gatekeeper in the renal tubules, controlling whether urate is excreted in the urine or reabsorbed back into the bloodstream. When the SLC2A9 gene functions optimally, it helps keep uric acid levels within a healthy range. However, genetic variations can alter the efficiency of this transporter, potentially leading to hyperuricemia, a condition characterized by elevated levels of uric acid in the blood.
Research Associations and Evidence Strength
Scientific research, including large-scale genome-wide association studies (GWAS), has consistently linked variants in the SLC2A9 gene to serum uric acid concentrations and gout. The evidence for the association between SLC2A9 and these traits is considered moderate to strong. Studies have shown that certain variants can explain a measurable percentage of the variance in uric acid levels across different populations. Gout occurs when high levels of uric acid lead to the formation of monosodium urate crystals in the joints, causing intense inflammation and pain. While rs736408 is statistically associated with these outcomes, it is important to note that genetics is only one piece of the puzzle. The development of gout is a complex process influenced by a combination of genetic predisposition, dietary habits, lifestyle factors, and environmental exposures. No single variant is typically sufficient to cause the condition on its own.
Population Frequency and Interpretation
The rs736408 variant is relatively common, with a global population frequency of approximately 20%. Because it is a common variant, it is found across many different ancestral groups, though the exact frequency can vary depending on the specific population studied. When interpreting genetic information, it is crucial to understand that having a specific genotype does not mean an individual will definitely develop a health condition. Genetic associations are based on statistical probabilities observed in large groups of people. This information should be viewed as a tool for understanding biological predispositions rather than a diagnostic result. If you are concerned about your uric acid levels or your risk for gout, it is essential to consult with a healthcare professional who can evaluate your clinical history, perform necessary blood tests, and provide personalized medical guidance.
How common is this variant?
The rs736408 variant is found in approximately 20% of the global population, with frequencies varying across different ancestral groups.
Frequently asked questions
Does having the rs736408 variant mean I will get gout?
No, having this variant does not guarantee that you will develop gout. Gout is a complex condition influenced by a combination of genetic, dietary, and environmental factors.
What is the relationship between SLC2A9 and uric acid?
The SLC2A9 gene produces a protein called GLUT9 that transports uric acid. Variations in this gene can affect how the kidneys reabsorb or excrete uric acid, impacting blood levels.
Can I change my genetic risk for gout?
You cannot change your DNA, but you can manage your risk factors. Lifestyle choices, such as diet and maintaining a healthy weight, are significant factors in managing uric acid levels.
Should I get tested for this SNP?
Genetic testing for specific SNPs is generally not used for diagnosing gout. If you have symptoms or concerns, consult a doctor for clinical blood tests to measure your actual uric acid levels.
Sources & further reading
Educational information only, last refreshed 10/2/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs736408?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants in SLC2A9
Functional variant in SLC2A9 significantly associated with serum uric acid levels and susceptibility to gout.
Common missense-associated variant in GLUT9 modulating serum urate homeostasis and risk of gout.
This SNP is linked to variations in serum uric acid levels and the risk of developing gout.