JMJD1C rs74506613: What Your Genotype Means
The genetic variant rs74506613 is a single nucleotide polymorphism located within the JMJD1C gene. Research has identified a statistical association between this variant and variations in the levels of circulating vascular endothelial growth factor (VEGF), a protein involved in tissue growth and vascular development.
What each genotype means
Typical VEGF association
This genotype represents the common baseline for this variant. Research indicates that individuals with this genetic profile do not carry the specific allele associated with altered circulating VEGF levels identified in large-scale genome-wide association studies.
This is the most common genotype observed in the general population.
Potential VEGF variation
Carrying one copy of the G allele is statistically associated with variations in circulating VEGF levels compared to the baseline. Because this association is based on population-level data, it is unclear how this specifically influences your individual physiology or appearance.
This genotype is rare, occurring in a small percentage of the population across studied ancestries.
Increased VEGF association
Carrying two copies of the G allele is linked to the strongest observed associations with circulating VEGF levels in genomic studies. While this protein is essential for vascular development, the clinical significance of this specific genetic variation remains limited and is not a diagnostic indicator of any health condition.
This genotype is very rare, found in a small fraction of individuals in global population databases.
Understanding rs74506613
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence. The variant rs74506613 is located on chromosome 10 within the intronic region of the JMJD1C gene. Introns are non-coding regions of a gene that are transcribed into pre-mRNA but are removed during the process of creating mature messenger RNA. Because this SNP sits in an intronic region, it does not directly alter the protein sequence of JMJD1C. Instead, researchers study such variants to determine if they influence gene expression, regulatory mechanisms, or other biological pathways. In the case of rs74506613, its primary interest in scientific literature stems from its strong statistical link to levels of circulating proteins in the blood rather than a direct impact on the structure of the JMJD1C protein itself.
The Role of the JMJD1C Gene
The JMJD1C gene, also known as KDM3C, encodes a protein that functions as a histone demethylase. Histones are proteins around which DNA wraps, and their modification—such as demethylation—plays a critical role in regulating how genes are turned on or off. By removing methyl groups from histone H3 lysine 9 (H3K9), the JMJD1C protein helps modulate chromatin accessibility, which influences transcriptional regulation. Beyond its role in chromatin, JMJD1C has been implicated in various cellular processes, including lipogenic gene transcription in the liver and signaling pathways involving proteins like STAT3. While the gene is expressed in various tissues, including embryonic stem cells and certain cancers, its specific contribution to the regulation of circulating VEGF levels remains a subject of ongoing investigation in the field of genomics.
Research and Evidence Strength
The association between rs74506613 and circulating VEGF levels was identified through large-scale genome-wide association studies (GWAS). These studies compare the genomes of thousands of individuals to find statistical correlations between specific genetic markers and measurable traits. The evidence linking rs74506613 to VEGF levels is considered robust in a statistical sense, with meta-analyses reporting high levels of significance. However, it is important to note that 'statistical association' does not imply a direct cause-and-effect relationship. While the variant is a reliable marker for VEGF variation, the biological mechanism by which this intronic SNP influences protein levels is not fully understood. Furthermore, the clinical significance of these VEGF variations in healthy individuals is not well-defined, and the evidence for this variant's impact on physical appearance or health outcomes remains limited.
Population Frequency
The variant rs74506613 is classified as a rare variant in many populations. Population frequency data, such as that provided by the 1000 Genomes Project and gnomAD, is essential for understanding how common a specific allele is across different ancestral groups. Because this SNP is rare, it is not found in the majority of the human population. Rare variants often require large sample sizes to be detected and studied effectively. If you are reviewing your own genetic data, you may find that you do not carry this variant at all. The rarity of the allele means that its impact on the general population's VEGF levels is likely restricted to a small subset of individuals, and its distribution can vary significantly depending on the specific ancestral background of the population being studied.
Interpreting Your Results
If you have received information about your rs74506613 genotype, it is important to view this data through an educational lens. This variant is a tool for researchers to understand the complex genetic architecture of protein regulation, but it is not a diagnostic marker for any specific medical condition. You cannot use this information to predict your health status, diagnose a disease, or determine your physical appearance. Genetic associations are complex and influenced by many other genes, environmental factors, and lifestyle choices. If you have concerns about your health, blood markers, or any medical symptoms, the most appropriate course of action is to consult with a qualified healthcare professional. They can provide context based on your full medical history and clinical testing, which are far more informative than a single genetic variant.
How common is this variant?
The rs74506613 variant is considered rare across most global populations, meaning the majority of individuals carry the common GG genotype.
Frequently asked questions
What does rs74506613 do to my body?
The rs74506613 variant is statistically associated with levels of circulating VEGF in the blood. It does not directly cause a specific physical trait or health condition, and its presence is just one of many factors that influence protein levels.
Is rs74506613 a disease-causing mutation?
No, rs74506613 is not classified as a disease-causing mutation. It is a common genetic variation that has been identified in research studies as a marker associated with normal biological variation in protein levels.
Can I change my VEGF levels based on this SNP?
There is no evidence that you can or should attempt to change your VEGF levels based on your genotype for this SNP. VEGF levels are regulated by complex biological systems, and any concerns about your blood markers should be discussed with a doctor.
Where can I find more information about JMJD1C?
You can find reliable information about the JMJD1C gene through resources like the National Library of Medicine's MedlinePlus Genetics or the GeneCards database. These platforms provide comprehensive summaries of gene functions and their roles in human biology.
Sources & further reading
Educational information only, last refreshed 9/14/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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