ABCA1 rs75252059: what the research says
Identified as a regulatory SNP influencing metabolic traits in Indigenous American populations.
What each genotype means
Typical metabolic profile
This genotype represents the most common form of this variant in many global populations. Research into rs75252059 is currently limited, and while it has been identified as a potential regulatory marker in Indigenous American populations, there is no established clinical diagnosis or specific health risk associated with this genotype. You should maintain standard health screenings as recommended by your healthcare provider.
This is the most frequent genotype observed in most global populations outside of specific Indigenous American groups.
Regulatory variant carrier
Carrying one copy of the G allele means you possess a variant that has been identified as a potential regulatory marker in Indigenous American populations. Current evidence regarding the functional impact of this specific variant is limited, and it is not considered a diagnostic marker for any disease. Please discuss any concerns about your metabolic health or lipid levels with your clinician.
This genotype is more frequently observed in individuals of Latin American and Indigenous American ancestry compared to other global populations.
Regulatory variant carrier
Carrying two copies of the G allele means you possess a variant that has been identified as a potential regulatory marker in Indigenous American populations. The scientific evidence for this variant is currently limited, and it is not a diagnostic indicator for metabolic conditions. As with any genetic finding, you should discuss your overall health and any specific metabolic concerns with your primary care physician.
This genotype is enriched in Latin American populations and is less common in individuals of European, African, or East Asian descent.
Enriched in Latin American populations
Curious what your genotype is for rs75252059?
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This variant upstream of ABCA1 influences ocular lipid homeostasis and correlates with elevated intraocular pressure and cup area.
This intergenic variant in the ABCA1 locus influences high-density lipoprotein cholesterol transport in the retina and predisposes to primary open-angle glaucoma.
Variant in the ABCA1 locus associated with high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular lipid regulation.