TMPRSS2 rs75603675: What Your Genotype Means
The rs75603675 variant is a single-nucleotide polymorphism located in the TMPRSS2 gene. Research has associated this variant with altered susceptibility to SARS-CoV-2 infection and potential differences in COVID-19 disease severity in specific populations.
What each genotype means
Typical TMPRSS2 variant
This genotype represents the most common form of the TMPRSS2 gene in many populations. Research suggests that individuals with this genotype may have a different susceptibility to SARS-CoV-2 infection compared to those carrying the T allele, though findings vary by ancestry and study design. This variant is not a diagnostic tool, and you should consult a healthcare professional regarding any concerns about infection risk or health outcomes.
This is a common genotype globally, though its frequency varies significantly by ancestry, being most prevalent in populations where the C allele is the major variant.
Heterozygous TMPRSS2 variant
Carrying one copy of the T allele results in the p.G8V substitution in the TMPRSS2 protein, which some research suggests may increase the accessibility of an endocytic signal that could facilitate SARS-CoV-2 entry into host cells. Studies in specific populations, such as Mexican Mestizos, have observed associations between this variant and altered susceptibility to COVID-19. Please discuss any health-related concerns or questions about infection risk with your clinician.
This heterozygous genotype is found at varying frequencies worldwide, with the T allele reaching frequencies of approximately 40% in non-Finnish European populations.
Increased TMPRSS2 variant
This genotype results in the p.G8V substitution in both copies of the TMPRSS2 gene, which has been investigated for its potential role in SARS-CoV-2 viral entry. Some studies have associated the presence of the T allele with increased susceptibility to infection or poorer clinical outcomes in specific cohorts. These associations are complex and influenced by ancestry; therefore, this information should not be used for medical diagnosis or to guide personal health decisions without professional medical advice.
This genotype is less common than the CC or CT genotypes in most populations, with the T allele being rare in East Asian populations but more frequent in European and other global groups.
Understanding the Variant and Gene
The rs75603675 variant is a specific change in the DNA sequence of the TMPRSS2 gene. The TMPRSS2 gene provides instructions for making an enzyme called transmembrane protease, serine 2. This enzyme is found on the surface of many cell types, including those in the respiratory tract. In the context of viral biology, TMPRSS2 plays a critical role by facilitating the entry of certain viruses, including SARS-CoV-2, into human cells. By acting as a molecular gateway, the protein helps the virus fuse with the host cell membrane, allowing the viral genetic material to enter and begin the replication process. Because of this function, variations in the gene that encodes this protein are of significant interest to researchers studying how host genetics influence viral infection and the subsequent immune response.
Research and Statistical Associations
Scientific studies have investigated the link between rs75603675 and COVID-19 outcomes. Research published in 2025 indicated that this variant is associated with an increased risk of SARS-CoV-2 infection in Mexican Mestizo populations. Other studies have explored its potential role in disease severity, with some data suggesting that specific genotypes may correlate with a higher risk of severe outcomes or mortality in certain cohorts, such as in Mongolian populations. However, evidence remains mixed; for instance, some studies in different ethnic groups have not found statistically significant differences in infection susceptibility or severity linked to this specific SNP. These findings highlight that the impact of genetic variants is often highly dependent on the ancestral background of the population being studied, and the evidence strength for this variant is currently considered moderate.
Interpreting Genetic Information
It is important to understand that genetic associations are statistical observations made at the population level, not individual medical diagnoses. Having a particular genotype does not guarantee that an individual will experience a specific health outcome, nor does it mean they are immune to infection. Many factors, including age, underlying health conditions, environmental exposures, and vaccination status, play a much larger role in determining how a person responds to a virus. Readers should view this information as a tool for understanding the complexity of human genetics rather than a predictive health report. If you have concerns about your health or susceptibility to infectious diseases, you should consult with a qualified healthcare professional who can provide guidance based on your complete medical history and current clinical standards.
How common is this variant?
The frequency of the rs75603675 variant is variable by ancestry, with specific risk alleles showing different prevalence rates across Mexican Mestizo and other global populations.
Frequently asked questions
Does having the rs75603675 variant mean I will get severe COVID-19?
No. Genetic associations are statistical trends observed in large groups of people and do not predict individual health outcomes. Many other factors, such as vaccination and overall health, are far more significant.
Is this variant used for medical testing?
Currently, this variant is primarily used in research settings to understand viral entry mechanisms. It is not a standard clinical test for diagnosing or managing COVID-19.
Why do results for this variant differ between studies?
Genetic associations often vary due to differences in ancestral backgrounds, sample sizes, and environmental factors. What is observed in one population may not be replicated in another.
What should I do if I know my genotype for this SNP?
You should continue to follow public health guidelines regarding infection prevention. If you have specific health concerns, discuss them with your doctor rather than relying on individual genetic markers.
Sources & further reading
Educational information only, last refreshed 11/6/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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