SUSD3 rs76292544: What Your Genotype Means
The rs76292544 variant is a single nucleotide polymorphism located within the SUSD3 gene. Research has suggestively associated this variant with differences in bleeding risk for patients treated with the anticoagulant medication rivaroxaban.
What each genotype means
Typical bleeding risk profile
This genotype represents the most common form of this variant. Research suggests that individuals with this genotype do not carry the specific genetic association linked to increased bleeding risk during treatment with rivaroxaban. Please discuss any concerns regarding your medication and bleeding risk with your clinician or pharmacist.
This is the most common genotype observed in the general population.
Increased bleeding risk association
Carrying one copy of the T allele has been suggestively associated with an increased risk of bleeding events in patients treated with the anticoagulant rivaroxaban. This association is based on clinical studies of patients with nonvalvular atrial fibrillation. You should discuss your specific bleeding risk and medication management with your healthcare provider.
This genotype is considered rare in the general population.
Elevated bleeding risk association
Research indicates that the TT genotype is associated with a significantly increased risk of bleeding events for individuals taking rivaroxaban. This finding is based on observational studies of patients with nonvalvular atrial fibrillation. It is important to consult with your doctor or pharmacist to review your treatment plan and monitor for potential side effects.
This genotype is rare, occurring at a low frequency across studied populations.
Understanding the rs76292544 Variant
The rs76292544 variant is a specific change in the DNA sequence located within the SUSD3 gene. In genetics, a single nucleotide polymorphism (SNP) like this represents a variation at a single position in the genome. Scientists study these variants to understand how small differences in our genetic code might influence biological processes or responses to medical treatments. Research indicates that this specific variant may influence the alternative splicing of SUSD3 mRNA, which is the process by which cells generate different versions of a protein from the same gene. This suggests that the variant could have functional consequences on how the SUSD3 gene is expressed in human tissues, particularly in whole blood samples where these differences have been observed.
The Role of the SUSD3 Gene
The SUSD3 gene, which stands for Sushi domain containing 3, encodes a protein that is primarily localized to the cell surface. While its exact biological functions are still being explored, it has been identified as a protein that may play a role in cell adhesion and migration. In the context of cancer research, SUSD3 has been studied as a potential prognostic biomarker in various tumor types, including breast cancer, where it may influence cell morphology and metastatic pathways. Beyond oncology, the gene is involved in complex cellular interactions and protein binding. Because it is expressed in various tissues, researchers are interested in how its activity might contribute to both normal physiological processes and the development of disease states.
Research and Clinical Associations
The primary clinical interest in rs76292544 stems from its potential association with medication response. A multicenter prospective cohort study investigated genetic factors influencing the pharmacodynamics and safety of rivaroxaban, a direct oral anticoagulant used to prevent blood clots. The study found a suggestive association between the rs76292544 variant and the incidence of bleeding events within 12 months of treatment. While the statistical evidence is considered moderate, it highlights the importance of pharmacogenomics in understanding why patients may experience different outcomes when taking the same medication. It is important to note that this is a complex trait likely influenced by many factors, and this variant is only one piece of a much larger puzzle regarding individual bleeding risk.
Interpreting Your Genetic Information
If you have information about your genotype for rs76292544, it is essential to interpret it within the context of your overall health and medical history. Genetic associations, particularly those related to drug response, are often based on statistical correlations observed in specific study populations and may not apply universally to all individuals. This information should never be used to make independent decisions about your medications or health care. If you are taking anticoagulants like rivaroxaban and have concerns about your bleeding risk or the potential impact of your genetics, you must discuss this with your clinician or pharmacist. They are the only ones qualified to evaluate your specific clinical situation, review your medication regimen, and determine if any adjustments are necessary based on your unique health profile.
How common is this variant?
The rs76292544 variant is generally considered rare across most populations. Specific frequency data can vary significantly by ancestry, and further large-scale genomic studies are needed to establish precise prevalence rates.
Frequently asked questions
What is the SUSD3 gene?
SUSD3 stands for Sushi domain containing 3. It is a gene that provides instructions for making a protein found on the surface of cells, which may be involved in cell adhesion and migration.
Does this variant mean I will have a bleeding problem?
No. A genetic association does not mean you will definitely experience a health issue. Bleeding risk is influenced by many factors, including other medications, underlying health conditions, and lifestyle.
Should I change my medication based on this SNP?
Absolutely not. You should never change or stop taking prescribed medication based on genetic information without consulting your doctor. Always speak with your healthcare provider about your specific risks and treatment plan.
Where can I find more information on this variant?
You can look up the rsID rs76292544 in public databases like the NCBI SNP database or the GWAS Catalog. These resources provide technical details on the variant and links to the scientific studies that have investigated it.
Sources & further reading
Educational information only, last refreshed 10/31/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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