POLD1 rs767410345: What Your Genotype Means
The rs767410345 variant is a rare genetic marker located within the POLD1 gene, which plays a critical role in maintaining genomic integrity. It is primarily used in population-specific genetic studies to better understand human genetic diversity.
What each genotype means
Common ancestral genotype
This genotype represents the most frequently observed sequence at this position in the POLD1 gene. It is considered the ancestral state and is not associated with known clinical conditions in current literature.
This is the most common genotype found across all global populations.
Heterozygous variant carrier
You carry one copy of the variant allele alongside the ancestral allele. Current research classifies this variant as a rare marker, and there is no established evidence linking this specific genotype to disease or altered POLD1 function.
This genotype is rare and observed at very low frequencies across most ancestral groups.
Homozygous variant genotype
You carry two copies of the variant allele. While this variant is located in the POLD1 gene, which is involved in DNA replication and repair, this specific change is not currently documented as having a clinical impact or functional consequence.
This genotype is extremely rare and is infrequently reported in large-scale population databases.
Understanding the POLD1 Gene
The POLD1 gene provides instructions for creating the catalytic subunit of DNA polymerase delta, an essential enzyme complex in human cells. This enzyme is primarily responsible for synthesizing the lagging strand of DNA during replication, ensuring that genetic information is copied accurately when cells divide. Beyond replication, POLD1 is deeply involved in various DNA repair pathways, which help fix errors that occur during the copying process or due to environmental damage. Because of its central role in maintaining the stability of the genome, the proper function of POLD1 is vital for cellular health. The gene is located on chromosome 19 and is expressed across many different tissues in the body, reflecting its fundamental importance in basic biological processes.
What is the rs767410345 Variant?
The rs767410345 variant is a single nucleotide polymorphism (SNP) situated within the POLD1 gene. In genomics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is cataloged in major genomic databases, including dbSNP, and serves as a marker for researchers investigating population genetics. Unlike some variants that are known to significantly alter the function of the POLD1 protein, rs767410345 is currently categorized as an ancestral or population-specific marker. Its presence does not necessarily imply a functional change in the enzyme's activity. Instead, it acts as a signpost that scientists use to track genetic lineages and study how specific variations are distributed across different human populations globally.
Research and Evidence Strength
Current scientific literature regarding rs767410345 is limited, and it is not widely associated with specific clinical conditions or disease phenotypes in the general population. While other mutations in the POLD1 gene are well-documented for their roles in hereditary cancer syndromes and DNA repair deficiencies, rs767410345 does not share this established clinical profile. The evidence strength for this variant is considered moderate, primarily because it is recognized in genomic databases as a valid, verifiable marker, but it lacks the extensive functional studies required to link it to specific health outcomes. Researchers continue to monitor such variants to determine if they might contribute to subtle differences in DNA replication efficiency or if they are simply neutral variations that have persisted in certain ancestral groups over time.
Interpreting Your Information
If you have encountered this variant in a personal genetic report, it is important to understand that it is a rare, population-specific marker. Because it is not currently linked to any known medical condition or diagnostic outcome, it is generally considered to be of neutral significance in a clinical context. You cannot use this information to predict health risks or guide medical decisions. Genetic data can be complex, and the presence of a rare variant does not equate to a health concern. If you have questions about your genetic results or how they relate to your family history, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your results within the context of your overall health and provide guidance based on established clinical standards.
How common is this variant?
The rs767410345 variant is rare and typically found only in specific ancestral populations, making its frequency highly variable depending on the group studied.
Frequently asked questions
Is rs767410345 associated with cancer?
While some mutations in the POLD1 gene are linked to hereditary cancer syndromes, rs767410345 is not currently associated with such conditions. It is considered a population-specific marker rather than a known disease-causing mutation.
What should I do if I have this variant?
Because this variant is not linked to any known health risks, no specific action is required. If you are concerned about your genetic results, you should discuss them with a healthcare professional or a genetic counselor.
Why is this variant called 'ancestral'?
The term 'ancestral' in this context refers to the variant's use as a marker to study human migration and genetic history. It helps researchers track how different groups of people are related based on shared genetic signatures.
Can I use this to predict my health?
No, this variant cannot be used to predict your health or diagnose any medical condition. It is a neutral genetic marker that does not provide actionable clinical information.
Sources & further reading
Educational information only, last refreshed 9/27/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs767410345?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29