Understanding rs76949143: A Genetic Variant on Chromosome 7
The genetic variant rs76949143 is a single nucleotide polymorphism located on the long arm of chromosome 7. It has been identified in scientific literature through genome-wide case-only analyses, with research exploring its potential associations with reproductive health phenotypes.
What each genotype means
Typical genetic profile
This genotype represents the most common sequence observed at this location in the human genome. Current research does not associate this specific sequence with any known clinical reproductive health conditions.
This is the most common genotype found across all major global populations.
Rare variant carrier
You carry one copy of a rare genetic variant identified in studies of reproductive health. Because this variant is rare and evidence is limited, its specific functional impact on your health remains uncertain and is not currently used for clinical decision-making.
This genotype is extremely rare and is found in a very small fraction of the global population.
Rare variant homozygous
You carry two copies of this rare genetic variant. While this variant has been noted in research regarding reproductive health, the clinical significance of carrying two copies is not well-established, and it should not be used to predict specific health outcomes.
This genotype is exceptionally rare and is observed in only a negligible percentage of individuals worldwide.
What is rs76949143?
The identifier rs76949143 refers to a specific single nucleotide polymorphism (SNP) located in an intergenic region on chromosome 7. In genomics, an intergenic region is a stretch of DNA located between genes. While these regions do not code for proteins directly, they often contain regulatory elements that can influence how nearby genes are expressed. This variant is cataloged in public databases like dbSNP, which serve as repositories for human genetic variation. Because it is located in a non-coding area, researchers study it to determine if it acts as a marker for other functional changes or if it plays a role in the complex regulatory landscape of the human genome. Understanding such variants requires looking at their position relative to known genes and assessing whether they correlate with specific biological traits observed in large-scale population studies.
Research and Associations
Scientific interest in rs76949143 has primarily emerged from genome-wide association studies (GWAS) and case-only analyses. These research methods are designed to identify statistical links between specific genetic markers and complex traits or health conditions. In the context of rs76949143, published research has highlighted its inclusion in studies investigating reproductive health phenotypes. It is important to note that the evidence strength for this association is currently considered moderate. In genetic research, a 'moderate' classification often suggests that while a statistical signal has been detected, further replication across diverse populations is necessary to confirm the biological significance. Because the variant is rare, it can be challenging to achieve the statistical power required to definitively link it to a specific clinical outcome. Consequently, current findings should be viewed as preliminary observations rather than established medical facts.
Interpreting Your Genetic Information
If you have encountered rs76949143 in a personal genetic report, it is essential to understand that this information is for educational purposes only. Genetic variants are rarely the sole cause of complex health outcomes; instead, they often interact with a wide array of environmental, lifestyle, and other genetic factors. You cannot use this information to diagnose a condition or predict a specific health outcome. If you have concerns about reproductive health or any other medical issue, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your results within the context of your personal and family medical history. Never make changes to your health management or medication regimen based on genetic data without first discussing the implications with a licensed clinician or pharmacist.
How common is this variant?
The variant rs76949143 is classified as rare, meaning the minor allele frequency is low across most global populations. Specific frequency data can vary significantly depending on ancestral background.
Frequently asked questions
What does it mean if a variant is 'intergenic'?
An intergenic variant is located in the DNA sequence between genes. While these regions do not code for proteins, they often contain regulatory switches that control when and how genes are turned on or off.
Is rs76949143 a cause of disease?
No. A genetic variant is a marker of difference, not necessarily a cause of disease. Most variants identified in GWAS have only a small, statistical association with a trait and do not act as a direct cause.
Where can I find more information on this SNP?
You can search for the rsID on the NCBI dbSNP database or the GWAS Catalog. These resources provide technical details, population frequencies, and links to the original research papers.
Should I be worried about this variant?
Genetic variants are a normal part of human diversity. Having a specific genotype does not mean you will develop a health condition, and you should discuss any health concerns with a medical professional.
Sources & further reading
Educational information only, last refreshed 9/18/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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The TT genotype of this SNP is associated with an increased number of piglets born alive and healthy births in Large White pig populations.
This lead variant has been identified in large-scale genome-wide association studies as being associated with female infertility phenotypes.
This variant in the estrogen receptor 1 gene is associated with altered protein secondary structure and potential susceptibility to polycystic ovary syndrome (PCOS).
This variant in the SREBF1 gene is linked to fertility traits and the timing of artificial insemination in cattle.
This variant is in high linkage disequilibrium with nonsynonymous SNPs in the CRTC2 gene and is associated with human reproductive behavior traits like age at first birth.
This missense variant (p.Ser20Ile) is linked to spermatogenic impairment in males.