GCKR rs780093: what the research says
A significant SNP identified through fine-mapping that demonstrates a consistent effect on triglyceride levels across different ancestral populations.
What each genotype means
Typical triglyceride profile
This genotype is associated with typical triglyceride levels in many populations. Research indicates that the G allele at this position is the one linked to variations in lipid levels, so individuals with the A/A genotype generally do not carry that specific genetic influence.
This is a common genotype found in both European and African ancestral populations.
Intermediate triglyceride association
Carrying one copy of the G allele is associated with measurable differences in triglyceride levels compared to those without it. Because this variant is linked to lipid metabolism, you may wish to discuss your lipid panel results with a healthcare provider to understand how your specific profile fits into your overall cardiovascular health.
This heterozygous genotype is frequently observed in diverse populations, including those of European and African descent.
Increased triglyceride association
The G/G genotype is associated with higher triglyceride levels in various studies across different ancestral groups. While this genetic marker is a known factor in lipid regulation, it is only one of many influences on your health; please consult with a clinician to interpret these findings in the context of your personal medical history.
This genotype is common and widely distributed across European and African cohorts.
Common in European and African cohorts
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This variant is associated with variations in fasting glucose and lipid levels, commonly studied in metabolic GWAS.
This variant in the glucokinase regulator (GCKR) locus is significantly associated with altered fasting plasma glucose, serum triglyceride levels, and hepatic fat accumulation.
This variant in the GCKR gene is strongly linked to altered glucokinase regulation, influencing fasting blood triglyceride and glucose levels.
A well-replicated regulatory/intronic variant within GCKR strongly associated with variation in fasting serum triglycerides, glucose levels, and lipid metabolism.
GCKR P446L modulates the glucokinase regulatory protein and balances triglyceride and glucose levels.