LHCGR rs781835924: What Your Genotype Means
The rs781835924 variant is an extremely rare genetic change located within the luteinizing hormone/choriogonadotropin receptor (LHCGR) gene region on chromosome 2. The LHCGR gene encodes a key receptor responsive to luteinizing hormone and human chorionic gonadotropin, hormones critical for sexual differentiation and reproductive biology. Current research has investigated this regulatory region for subtle impacts on reproductive competence, though clinical evidence remains moderate and exploratory.
What each genotype means
Typical receptor function
You carry two copies of the common C allele in the LHCGR region. Current population evidence shows no regulatory disruption or altered reproductive signaling associated with this baseline genotype. Because this is the standard genomic sequence, reproductive hormone receptor expression is expected to function typically.
Carried by more than 99.9% of individuals across all major global ancestries.
Rare regulatory variant carrier
You carry one copy of the rare T allele near the LHCGR gene. Research into this variant evaluates possible regulatory effects on luteinizing hormone and choriogonadotropin receptor signaling, but functional evidence remains preliminary and limited. Carrying this single variant allele has not been conclusively established to cause reproductive impairment on its own.
Carried by fewer than 1 in 2,500 individuals globally, with an overall gnomAD minor allele frequency below 0.0002.
Atypical receptor regulatory profile
You carry two copies of the rare T allele in the LHCGR regulatory region. While inactivating disruptions in LHCGR can alter gonadotropin responsiveness, the specific biological impact of this homozygous genotype is poorly characterized due to its extreme scarcity in published cohorts. Further clinical research and endocrine evaluation are necessary to establish whether this genotype alters receptor expression or reproductive traits.
Extremely rare; observed in far fewer than 1 in 1,000,000 individuals globally.
Understanding rs781835924 and the LHCGR Gene
The single nucleotide variant rs781835924 is located on chromosome 2 within the genomic region encompassing the LHCGR gene. According to [MedlinePlus Genetics](https://medlineplus.gov/genetics/gene/lhcgr/), the LHCGR gene provides crucial genetic instructions for producing the luteinizing hormone/choriogonadotropin receptor. This protein is a G-protein-coupled receptor primarily active in the gonads, including the Leydig cells of the testes and the granulosa and theca cells of the ovaries. The receptor operates like a lock, specifically binding two important reproductive hormones: luteinizing hormone (LH) and chorionic gonadotropin (hCG). When activated, it directs intracellular biochemical signals essential for healthy endocrine communication, the production of sex steroids like testosterone and progesterone, and normal sexual maturation. Variants situated in regulatory non-coding or boundary regions of the gene may alter how efficiently the receptor is transcribed or expressed, prompting ongoing genomic research into their potential biological relevance.
Research Associations and Evidence Strength
Scientific investigations have evaluated variation in the LHCGR locus for potential associations with human reproductive competence, pubertal timing, and hormone-related traits. In the scientific catalog, rs781835924 is specifically documented as a variant analyzed for regulatory disruption that could potentially alter receptor activity or hormone sensitivity. While severe protein-altering mutations in LHCGR are known causes of rare conditions like Leydig cell hypoplasia or precocious puberty, the evidence linking rs781835924 itself to noticeable clinical traits is currently rated as moderate. Most of the findings derive from genomic screening and association methodologies rather than conclusive diagnostic studies. At present, researchers view this variant primarily as a point of interest for understanding how non-coding genomic variation modulates endocrine pathways, rather than as a definitive driver of any health condition or disorder.
Population Distribution and Frequency
Data from large-scale reference databases such as the Genome Aggregation Database indicate that rs781835924 is exceptionally uncommon across global human populations. In gnomAD, its minor allele frequency (MAF) is recorded at less than 0.0002, which translates to fewer than two in every ten thousand sequenced alleles. Because it appears so infrequently, the vast majority of people worldwide inherit two copies of the common reference allele. To date, homozygous carriers of the minor variant allele have not been widely documented in standard genomic reference sets. When variants exist at such low frequencies, scientists must exercise caution, as smaller sample sizes limit the statistical power required to confirm ancestry-specific patterns or establish strong phenotype correlations across diverse populations.
What You Can and Cannot Do with This Result
Finding this variant in a genetic report should be viewed purely as educational genomic information, not as a diagnostic test. Because the evidence linking rs781835924 to reproductive outcomes is moderate and exploratory, having or lacking this variant cannot diagnose infertility, hormone imbalances, or reproductive disorders. Genetic variation in endocrine systems works in concert with many other genes, environmental exposures, age, and overall lifestyle. You should never alter any medication, fertility plan, or hormone therapy based on this variant. If you have personal questions or concerns about reproductive health, pubertal development, or laboratory hormone levels, discuss them directly with a qualified physician, endocrinologist, or board-certified genetic counselor.
How common is this variant?
According to gnomAD population records, rs781835924 is an extremely rare variant with a minor allele frequency (MAF) below 0.0002 across all surveyed global ancestries.
Frequently asked questions
Does having the rs781835924 variant mean I will have fertility problems?
No. The current scientific evidence linking rs781835924 to reproductive competence is moderate and non-diagnostic. The presence of this rare variant does not mean you are infertile or will experience reproductive issues.
What role does the LHCGR gene play in the human body?
The LHCGR gene produces a receptor that responds to luteinizing hormone and human chorionic gonadotropin. It is essential for normal sex steroid production, pubertal development, and female ovulation.
How common is rs781835924 in the general population?
It is exceedingly rare. Reference databases like gnomAD report its minor allele frequency at less than 0.02% (MAF < 0.0002), meaning almost all individuals carry two copies of the common reference allele.
Should I make changes to hormone medications based on this variant?
No. You should never adjust prescription treatments or hormone medications based on personal genetic results without guidance. Always consult your prescribing doctor or pharmacist before making any changes.
Sources & further reading
Educational information only, last refreshed 9/11/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Intronic regulatory variant in LHCGR modulating luteinizing hormone and human chorionic gonadotropin signaling sensitivity during human folliculogenesis.
Polymorphism in the luteinizing hormone/choriogonadotropin receptor gene linked to variation in ovarian sensitivity to gonadotropins during assisted reproduction.
A missense polymorphism (N291S) in the luteinizing hormone/choriogonadotropin receptor gene that influences receptor signaling efficiency and sensitivity to exogenous gonadotropins in ovarian stimulation protocols.
Regulatory SNP in LHCGR associated with ovarian responsiveness.
Luteinizing hormone/choriogonadotropin receptor gene locus polymorphism linked to polycystic ovary syndrome susceptibility.
Intronic regulatory variant in LHCGR modulating luteinizing hormone and human chorionic gonadotropin signaling, linked to susceptibility to polycystic ovary syndrome (PCOS).