FAM19A5 rs807567: Understanding This Genetic Variant
The rs807567 variant is a common single-nucleotide polymorphism located within the FAM19A5 gene. It has been identified in various genome-wide association studies exploring potential links to neurological and neurobehavioral traits.
What each genotype means
Typical baseline neurobehavioral profile
You carry two copies of the C allele at rs807567 within the FAM19A5 gene region. In published genome-wide association studies, this genotype represents the standard baseline profile and is not associated with altered neurobehavioral or cognitive trait tendencies. Because research on this specific variant remains limited, these statistical findings do not constitute a medical diagnosis or predict individual neurological outcomes.
Carried by approximately 45% to 55% of individuals across European and multi-ancestry populations.
Intermediate neurobehavioral trait association
You carry one copy of the T allele and one copy of the C allele at rs807567. Some exploratory neurobehavioral and psychiatric association studies evaluate the T allele for subtle statistical shifts in neurological trait variation, though overall evidence remains limited and mixed across ancestral cohorts. Having this genotype reflects an intermediate population tendency rather than a health risk or definitive clinical outcome.
Carried by roughly 35% to 45% of people in most global populations.
Altered neurobehavioral trait association
You carry two copies of the T allele at rs807567 in the FAM19A5 locus. Limited genome-wide association research has evaluated homozygosity for this allele in relation to subtle neurobehavioral and cognitive phenotypic variation. The current scientific evidence is preliminary and not clinically actionable, meaning it does not indicate any medical or psychiatric condition.
Carried by roughly 5% to 15% of individuals depending on ancestral background.
What is rs807567?
The rs807567 variant is a single-nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. In the context of human genetics, SNPs are the most common type of genetic variation. This specific variant is located within the FAM19A5 gene, which provides instructions for producing a protein known as TAFA-5. Because rs807567 is a common variant, it is found frequently across diverse human populations. Researchers study such variants to understand how subtle differences in our genetic code might contribute to the diversity of human traits, including those related to brain function and behavior. It is important to note that the presence of a specific SNP does not determine a trait on its own; rather, it is one of many factors that researchers investigate to build a more complete picture of human biology.
The Role of the FAM19A5 Gene
The FAM19A5 gene, also known as TAFA5, belongs to a family of genes that encode proteins predominantly expressed in the brain. These TAFA proteins are thought to function as brain-specific chemokines or neurokines. Chemokines are signaling molecules that typically regulate the movement and activity of immune cells, but in the nervous system, they are believed to play a role in the regulation of both immune and nervous system cells. By acting as signaling molecules, the protein produced by FAM19A5 may influence how neurons communicate or how the brain responds to various stimuli. Because of this expression pattern, scientists are interested in how variations in this gene might relate to neurological processes. Research into this gene is ongoing, and it remains a subject of interest for those studying the molecular foundations of neurobiology.
Research Associations and Evidence Strength
The association between rs807567 and specific human traits is currently categorized as having limited evidence. While genome-wide association studies (GWAS) have identified this variant in investigations exploring neurological and neurobehavioral traits, these findings are often preliminary. In genetic research, a 'limited' evidence strength suggests that while a statistical signal has been observed, it may not be robustly replicated across all studies or may have a very small effect size. It is common for initial GWAS findings to require further validation through larger, more diverse cohorts to confirm the biological significance of a variant. Consequently, while rs807567 is a documented marker in the GWAS Catalog, it should not be interpreted as a definitive cause of any specific condition or behavioral trait. The scientific community continues to analyze such variants to determine if they play a meaningful role in human health.
What You Can Do With This Information
Information about genetic variants like rs807567 is primarily intended for educational and research purposes. Because the evidence linking this variant to specific outcomes is limited, it does not provide actionable medical information. You cannot use this data to diagnose a condition, predict future health outcomes, or guide medical treatment. If you have received genetic testing results that include this variant, it is important to view them in the context of your overall health and family history. Genetic associations are complex and often involve the interaction of many genes and environmental factors. If you have concerns about your neurological health or any other medical issues, the most appropriate step is to consult with a qualified healthcare professional or a genetic counselor. They can help you interpret your results accurately and discuss any necessary steps based on your individual clinical situation.
How common is this variant?
The rs807567 variant is considered a common allele across multi-ancestry populations, meaning it is found at significant frequencies in diverse groups worldwide.
Frequently asked questions
Is rs807567 a disease-causing mutation?
No, rs807567 is a common genetic variant, not a disease-causing mutation. It is a normal variation in the human genome that has been studied for its potential association with certain traits, but it is not considered a direct cause of any specific disease.
Can I use this variant to predict my risk for neurological conditions?
No, you cannot use this variant to predict your risk for neurological conditions. The evidence linking rs807567 to such traits is limited, and genetic risk is typically determined by a combination of many different factors, not a single variant.
Where can I find more information about FAM19A5?
You can find more information about the FAM19A5 gene through reputable scientific databases such as the NCBI Gene database or the GWAS Catalog. These resources provide detailed information on gene function and known research associations.
Should I be worried if I have the GG genotype?
No, there is no reason to be worried about having the GG genotype. It is a common genetic variation found in healthy individuals, and it does not indicate a medical problem or a need for clinical intervention.
Sources & further reading
Educational information only, last refreshed 10/12/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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