Understanding rs874881: A Genetic Variant on Chromosome 1
The genetic variant rs874881 is a missense change located on chromosome 1. It is currently categorized as a trait-associated variant with limited evidence regarding its specific clinical impact.
What each genotype means
Common genetic baseline
This genotype represents the most frequently observed sequence at this location in many global populations. Research into this variant, particularly in the context of the PADI4 gene, has explored its potential association with susceptibility to rheumatoid arthritis in specific ethnic groups. Current evidence is limited and findings may vary significantly based on ancestry and environmental factors like smoking.
This is the most common genotype globally, though exact frequencies vary significantly by ancestral background.
Variant carrier status
Carrying one copy of the C allele at this position has been studied for potential links to autoimmune conditions such as rheumatoid arthritis. Because the evidence is limited and often specific to certain populations, this result should not be used to predict individual health outcomes. Please consult with a healthcare professional if you have concerns about autoimmune symptoms.
This heterozygous genotype is found at varying frequencies across different global populations.
Variant carrier status
Carrying one copy of the T allele at this position has been investigated in studies regarding disease susceptibility, including rheumatoid arthritis. The clinical significance of this variant remains under investigation, and current data does not support using this information for diagnostic purposes. Discuss any health concerns with your clinician.
This heterozygous genotype is observed at low to moderate frequencies depending on the population studied.
Rare variant profile
This genotype involves two copies of the C allele at this location. While some research suggests associations between PADI4 variants and inflammatory conditions, the evidence for this specific genotype is not definitive and may be influenced by other genetic or environmental factors. This information is for educational purposes and is not a medical diagnosis.
This genotype is relatively rare in most populations compared to the major allele.
Rare variant profile
This genotype involves two copies of the T allele at this location. Studies have examined this variant in relation to immune system function and disease risk, but results are inconsistent and often limited to specific regional cohorts. This result does not provide a clear clinical picture and should not be used to guide medical decisions.
This genotype is observed at very low frequencies in most studied populations.
Compound variant carrier
This genotype consists of one C allele and one T allele. Research into this variant is ongoing, and while some studies suggest potential links to autoimmune susceptibility, the findings are not conclusive. As with all genetic findings, this should be interpreted in the context of your overall health and family history by a qualified medical professional.
This genotype is rare and typically found at low frequencies across diverse populations.
What is rs874881?
The variant rs874881 is a single nucleotide polymorphism (SNP) located on chromosome 1. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is classified as a missense variant, meaning the change in the DNA sequence results in a different amino acid being incorporated into a protein product. It is mapped to a specific location on the human genome, and it has been cataloged in major databases like dbSNP. Because it is located in a region that may influence protein structure or function, researchers monitor such variants to determine if they contribute to observable biological traits or health conditions. However, not all missense variants have a significant impact on human health, and many are considered benign variations that contribute to the natural diversity of the human population.
Research and Clinical Significance
The clinical significance of rs874881 is currently characterized by limited evidence. In the context of genomic research, 'limited evidence' means that while the variant has been identified and cataloged, there is not yet a robust consensus or sufficient peer-reviewed data to definitively link it to a specific disease or clinical outcome. It is important to distinguish between a genetic association and a direct cause of a condition. Many variants identified in large-scale studies are found to have very small effects or are simply markers that happen to be inherited alongside other functional genetic elements. As of now, rs874881 does not have a widely recognized, high-impact clinical classification in major medical databases. Ongoing research continues to investigate the functional consequences of such variants, but for the general public, this variant remains a subject of scientific study rather than a diagnostic tool.
Population Frequency
The frequency of rs874881 varies across different human populations. Genetic variants are rarely distributed uniformly; instead, their prevalence often depends on the ancestral background of a specific group. Databases like gnomAD and the 1000 Genomes Project provide data on how often the different alleles (G, C, or T) appear in diverse cohorts. Because this variant is considered to have variable frequency, it is common to see different percentages reported depending on whether the data is drawn from European, African, East Asian, or other population groups. This variability is a hallmark of human genetic diversity. When interpreting frequency data, it is essential to remember that a variant being 'common' in a population does not necessarily imply it is harmful; many common variants are neutral and simply represent the normal range of human genetic variation.
What You Can Do With This Information
If you have encountered rs874881 in a personal genetic report, it is important to maintain a balanced perspective. Because the evidence for this variant is limited, it is not currently used to make medical diagnoses or to predict specific health outcomes. Genetic information can be complex, and it is often easy to over-interpret findings that lack strong clinical validation. You cannot use this information to issue medical instructions or change your health habits. If you are concerned about your genetic profile or have questions about how specific variants might relate to your health, the best course of action is to consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your results within the context of your overall health history and family background, ensuring that you do not make decisions based on incomplete or preliminary scientific data.
How common is this variant?
The frequency of rs874881 is variable across global populations, with the G allele typically serving as the ancestral reference. Specific allele frequencies depend heavily on the ancestral background of the population being studied.
Frequently asked questions
Is rs874881 associated with a specific disease?
Currently, there is no definitive evidence linking rs874881 to a specific disease. It is categorized as a variant with limited evidence, meaning its clinical impact remains unknown.
Should I be worried if I have this variant?
No, there is no reason for concern. Most genetic variants, including those with limited evidence, are neutral and do not have a significant impact on your health.
Where can I find more information about this SNP?
You can look up rs874881 in public databases like the NCBI dbSNP or the Ensembl genome browser. These sites provide technical details on the variant's location and reported frequencies.
Can I use this information to change my medication?
No. You should never change your medication or treatment plan based on genetic variants without first consulting your doctor or pharmacist.
Sources & further reading
Educational information only, last refreshed 9/29/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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