AKTIP rs9302648: Understanding This Genetic Variant
The rs9302648 variant is a single nucleotide polymorphism located within the AKTIP gene. It has been investigated in scientific literature for potential associations with susceptibility to suicidal behavior in individuals diagnosed with bipolar disorder.
What each genotype means
Common genetic profile
This is a common genotype for this variant. Research investigating this specific variant in the context of bipolar disorder and suicidal behavior has yielded negative or inconsistent results, meaning there is no established clinical association with this genotype.
This genotype is found in a significant portion of the global population, consistent with the variant's high global minor allele frequency.
Common genetic profile
This is a common genotype for this variant. Research investigating this specific variant in the context of bipolar disorder and suicidal behavior has yielded negative or inconsistent results, meaning there is no established clinical association with this genotype.
This genotype is found in a significant portion of the global population, consistent with the variant's high global minor allele frequency.
Common genetic profile
This is a common genotype for this variant. Research investigating this specific variant in the context of bipolar disorder and suicidal behavior has yielded negative or inconsistent results, meaning there is no established clinical association with this genotype.
This genotype is found in a significant portion of the global population, consistent with the variant's high global minor allele frequency.
What is rs9302648?
The variant rs9302648 is a single nucleotide polymorphism (SNP) found on chromosome 16 at position 53,493,869 (GRCh38). A SNP represents a variation at a single position in a DNA sequence among individuals. In the case of rs9302648, the variation involves the nucleotides guanine (G) and thymine (T). This variant is situated within the AKTIP gene, which encodes the AKT-interacting protein. Genetic variants like rs9302648 are cataloged by researchers to determine if specific DNA changes correlate with physical traits, health conditions, or responses to environmental factors. Because this variant is located within a gene that plays a role in cellular signaling, it has been a subject of interest for researchers studying the genetic architecture of complex psychiatric conditions.
The Role of the AKTIP Gene
The AKTIP gene, also known as AKT-interacting protein, provides instructions for making a protein that interacts with the AKT signaling pathway. This pathway is fundamental to many cellular processes, including cell growth, proliferation, and survival. Because the AKT pathway is highly active in the brain and involved in neuronal function, researchers often examine genes within this pathway when studying psychiatric disorders. While the exact biological impact of the rs9302648 variant on the function of the AKTIP protein is not fully understood, its location within this gene makes it a candidate for study in the context of stress response and mental health. Understanding how such genes function provides a foundation for broader research into the molecular mechanisms that may contribute to the complexity of human behavior and psychiatric health.
Research and Evidence Strength
The evidence linking rs9302648 to clinical outcomes is considered moderate. Scientific studies have explored whether this variant contributes to the risk of suicidal behavior in patients already diagnosed with bipolar disorder. However, findings in this area are not always consistent. For instance, some research has specifically investigated AKT-related genes and found that while certain variants in the broader AKT pathway may show associations, other studies have reported no significant link between rs9302648 and the specific outcomes being measured. It is important to recognize that psychiatric conditions are polygenic, meaning they are influenced by many different genetic variants, as well as environmental and social factors. Consequently, a single SNP like rs9302648 is unlikely to be a sole determinant of any complex behavioral trait or clinical diagnosis.
Population Frequency
The frequency of the rs9302648 variant is variable across different human populations. According to data from large-scale genomic databases, the Global Minor Allele Frequency (GMAF) is approximately 0.45. This indicates that both the G and T alleles are relatively common in the general population. Because allele frequencies can differ significantly based on ancestral background, it is common to see variations in how often this SNP appears in different groups. Researchers use these population-wide frequency data to help distinguish between common genetic variations and rare mutations that might have a more significant impact on health. When interpreting genetic data, understanding the prevalence of a variant in one's own ancestral group is a standard part of genomic analysis.
What This Information Means for You
If you have information about your genotype for rs9302648, it is important to view it within the context of current scientific limitations. Genetic testing for this variant is not a diagnostic tool for bipolar disorder or any other mental health condition. Because the association between this SNP and clinical outcomes is not definitive, it cannot be used to predict individual health risks or guide medical treatment. If you have concerns about your mental health or are managing a condition like bipolar disorder, please consult with a qualified healthcare professional or psychiatrist. They can provide personalized care based on your clinical history and symptoms, which are far more reliable indicators of health than any single genetic variant. Never make changes to your medication or treatment plan based on genetic data without first discussing it with your clinician or pharmacist.
How common is this variant?
The rs9302648 variant is common, with a global minor allele frequency of approximately 0.45, though specific frequencies vary by ancestry.
Frequently asked questions
Can rs9302648 diagnose bipolar disorder?
No, rs9302648 cannot diagnose bipolar disorder. Psychiatric conditions are complex and influenced by many genetic and environmental factors, and this variant is not a clinical diagnostic marker.
Should I change my medication based on this SNP?
No. You should never change your medication or treatment plan based on genetic information. Always discuss your medications and any concerns with your clinician or pharmacist.
Is rs9302648 a rare mutation?
No, rs9302648 is a common genetic variant. It is found at a high frequency across many different human populations.
Where can I find more information on AKTIP?
You can find more information on the AKTIP gene through resources like the National Library of Medicine's MedlinePlus Genetics or the NCBI Gene database.
Sources & further reading
Educational information only, last refreshed 9/26/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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