HSD11B1 rs932335: What Your Genotype Means
The rs932335 variant is a common genetic change located within the HSD11B1 gene. Research has explored its potential association with bone mineral density and fracture risk in postmenopausal women.
What each genotype means
Typical bone density profile
This genotype represents the most common genetic configuration at this position in the HSD11B1 gene. Research indicates that this variant is associated with variations in bone mineral density and fracture risk in postmenopausal women, though individual outcomes are influenced by many lifestyle and genetic factors.
This is the most common genotype observed in most global populations.
Varied bone density association
Carrying one copy of the variant allele may be associated with slight differences in bone mineral density compared to the common genotype. Because this association is based on statistical trends in large populations, it does not predict individual bone health or fracture risk; please discuss your overall bone health and any concerns with your healthcare provider.
This heterozygous genotype is found at moderate frequencies across diverse populations.
Increased bone density association
This genotype is associated with specific trends in bone mineral density and fracture risk in postmenopausal women as identified in genetic association studies. These findings reflect statistical correlations across large groups and are not diagnostic of your personal bone health. You should consult with a clinician to discuss bone density screening or lifestyle factors relevant to your health.
This genotype is less common than the AA configuration but is present at significant frequencies in many populations.
Understanding the rs932335 Variant
The rs932335 variant is a single nucleotide polymorphism (SNP) located on chromosome 1. In the context of human genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is situated within the HSD11B1 gene, which provides instructions for making an enzyme called 11-beta-hydroxysteroid dehydrogenase type 1. Scientists study such variants to understand how subtle differences in our genetic code might influence biological processes. Because this variant is common, it has been included in various genetic studies aimed at identifying markers that may correlate with specific health traits. It is important to note that the presence of a specific SNP does not determine a health outcome on its own, as complex traits like bone health are influenced by a combination of genetic, environmental, and lifestyle factors.
The Role of the HSD11B1 Gene
The HSD11B1 gene encodes an enzyme that plays a critical role in the regulation of glucocorticoids, which are hormones involved in metabolism, immune response, and inflammation. Specifically, this enzyme converts inactive cortisone into active cortisol within various tissues. Cortisol is a hormone that, while essential for normal body function, can have complex effects on bone metabolism when levels are dysregulated. By modulating the local availability of active cortisol, the HSD11B1 enzyme helps maintain hormonal balance in tissues such as the liver, adipose tissue, and bone. Because glucocorticoids are known to influence the activity of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts), researchers have investigated whether variations in the HSD11B1 gene might contribute to differences in bone mineral density or the structural integrity of the skeleton over time.
Research and Evidence Strength
The association between rs932335 and bone health is considered to have moderate evidence. Published research, including studies focused on postmenopausal women, has examined whether this variant predicts bone mineral density and the risk of fractures. While some studies have suggested a statistical link, it is essential to interpret these findings with caution. Genetic association studies often identify correlations that may not imply direct causation. Furthermore, the effect sizes of individual SNPs on complex traits like bone density are typically very small. The scientific community continues to evaluate how genetic variations in hormone-regulating genes interact with other factors to influence skeletal health. Because the evidence is not definitive, this variant is not currently used as a standalone diagnostic tool for predicting fracture risk in clinical practice.
Population Frequency
The rs932335 variant is considered a common genetic marker. According to data from large-scale genomic databases, the variant is widely distributed across various global populations, meaning that many individuals carry one or more copies of the minor allele. This high frequency makes it a frequent subject of study in genome-wide association efforts, as common variants are often easier to track in large cohorts than rare mutations. However, the specific frequency of the C and G alleles can vary significantly depending on ancestral background. Understanding these frequency differences is a key part of modern genomics, as it helps researchers determine whether a genetic association is consistent across different groups or if it is specific to certain populations.
Interpreting Your Genetic Information
If you have information about your genotype for rs932335, it is important to view it as one small piece of a much larger puzzle. Genetic testing for common variants like this is often provided for educational or informational purposes and should not be used to make medical decisions. You cannot change your genotype, but you can influence your bone health through lifestyle choices such as regular weight-bearing exercise, adequate calcium and vitamin D intake, and avoiding smoking. If you are concerned about your bone mineral density or your risk of fractures, the most effective step is to consult with a healthcare professional. They can perform clinical assessments, such as a DEXA scan, which are the standard methods for evaluating bone health. Always discuss any health-related genetic findings with your doctor or a genetic counselor before taking action.
How common is this variant?
The rs932335 variant is common, with a global minor allele frequency of approximately 20%.
Frequently asked questions
Does having the rs932335 variant mean I will get osteoporosis?
No. Having a specific genotype for this variant does not mean you will develop osteoporosis. Bone health is a complex trait influenced by many genes, as well as diet, exercise, and other environmental factors.
Can I use this genetic information to predict my fracture risk?
Current evidence is not sufficient to use this variant as a reliable predictor of fracture risk. Clinical risk assessment should be based on professional medical evaluations, such as bone density scans.
Should I take supplements based on my rs932335 genotype?
No. You should never start or change a supplement regimen based on a genetic variant. Always consult with your physician or a registered dietitian to determine if supplements are appropriate for your specific health needs.
Is this variant related to other health conditions?
Some research has explored the role of HSD11B1 variants in metabolic and endocrine health, including obesity and breast cancer risk. However, these associations are complex and often require further validation.
Sources & further reading
Educational information only, last refreshed 9/18/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs932335?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29