GDAP2 rs935208076: What Your Genotype Means
The rs935208076 variant is a rare genetic change located within or near the GDAP2 gene. Recent scientific research has identified this variant as a lead locus associated with Alzheimer's disease in specific diverse biobank cohorts.
What each genotype means
Typical GDAP2 trait profile
This rare variant in the GDAP2 gene has been identified in meta-analyses as a potential marker associated with Alzheimer's disease. As this is a rare finding, its clinical significance for an individual remains a subject of ongoing research.
This is a rare variant.
Typical GDAP2 trait profile
This rare variant in the GDAP2 gene has been identified in meta-analyses as a potential marker associated with Alzheimer's disease. As this is a rare finding, its clinical significance for an individual remains a subject of ongoing research.
This is a rare variant.
Typical GDAP2 trait profile
This rare variant in the GDAP2 gene has been identified in meta-analyses as a potential marker associated with Alzheimer's disease. As this is a rare finding, its clinical significance for an individual remains a subject of ongoing research.
This is a rare variant.
Understanding the Variant and Its Location
The rs935208076 variant is a specific change in the human genome cataloged by its rsID, which stands for Reference SNP cluster ID. This identifier helps researchers track specific locations on a chromosome where a single nucleotide polymorphism (SNP) occurs. In the case of rs935208076, the variant is situated in the genomic region associated with the GDAP2 gene, which stands for Ganglioside Induced Differentiation Associated Protein 2. Genetic variants like this are often identified through large-scale genome-wide association studies (GWAS), which compare the DNA of individuals with a specific condition to those without it to find statistical patterns. Because this variant is classified as rare, it is not found in the majority of the population, making it a subject of interest for researchers trying to understand the complex genetic architecture of neurodegenerative conditions.
The Role of the GDAP2 Gene
The GDAP2 gene provides instructions for producing a protein that is involved in cellular processes. While the exact biological mechanisms linking GDAP2 to brain health are still being investigated, genes in this family are often studied for their roles in neuronal differentiation and cellular signaling. In the context of Alzheimer's disease research, scientists look at how variations in or near these genes might influence the risk of developing the condition. It is important to note that having a variant in a gene does not mean that the gene is malfunctioning or that a person will definitely develop a disease. Instead, researchers study these associations to better understand the biological pathways that may contribute to disease progression over time. Ongoing studies continue to map the expression of these genes in different brain tissues to clarify their potential impact on cognitive health.
Research Associations and Evidence Strength
The association between rs935208076 and Alzheimer's disease was highlighted in recent meta-analyses involving diverse biobank cohorts, such as the All of Us research program. Researchers identified this variant as a genome-wide significant locus, meaning the statistical evidence for its association with the trait reached a high threshold of confidence within the studied populations. However, the evidence strength is currently considered moderate, as these findings are often specific to the cohorts studied and require further replication in larger, more diverse groups to confirm the biological link. It is common in genetic research for initial findings to be refined as more data becomes available. The scientific community views these results as a starting point for deeper investigation rather than a definitive diagnostic marker. As with all genetic associations, the presence of this variant is one of many factors, including environment and lifestyle, that contribute to overall health.
What This Information Means for You
If you encounter information about rs935208076, it is essential to understand that this is a statistical finding from population-level research. This variant is not a diagnostic test for Alzheimer's disease, and it cannot predict an individual's future health outcomes. Genetic associations are complex and often involve many different genes and environmental factors working together. You cannot use this information to make medical decisions or to assess your personal risk in isolation. If you have concerns about your cognitive health or family history, the most appropriate step is to consult with a qualified healthcare professional or a genetic counselor. They can provide context based on your personal medical history and help you understand what current science says about genetic testing and risk assessment. Always rely on clinical guidance rather than individual genetic markers when considering your health.
How common is this variant?
The rs935208076 variant is classified as rare, meaning it appears at a very low frequency across most global ancestral populations.
Frequently asked questions
Is rs935208076 a diagnostic test for Alzheimer's?
No, rs935208076 is not a diagnostic test. It is a genetic variant identified through statistical research and does not determine whether an individual will develop Alzheimer's disease.
What does 'rare lead variant' mean?
A rare lead variant is a specific genetic marker that appears infrequently in the population but serves as a primary signal in a genome-wide association study for a particular trait.
Should I be worried if I have this variant?
Genetic variants are only one piece of a very large puzzle. You should not be worried based on a single variant; instead, focus on overall health and consult a doctor if you have concerns.
Where can I find more information on GDAP2?
You can search for the GDAP2 gene on resources like the NCBI Gene database or MedlinePlus Genetics to learn about its known biological functions.
Sources & further reading
Educational information only, last refreshed 11/7/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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