DAOA-Linked Variant rs947267: What Your Genotype Means
The rs947267 variant is a common genetic polymorphism located within the DAOA gene region. It has been the subject of numerous studies investigating potential statistical associations with psychiatric conditions, though findings remain inconsistent across global populations.
What each genotype means
Common genetic variant profile
This genotype represents one of the common forms of this intergenic variant. Research indicates this site is associated with complex trait architecture in large-scale studies, though the specific biological mechanism remains under investigation. This finding is based on statistical associations and does not provide a medical diagnosis.
This is a common genotype observed across diverse global populations.
Common genetic variant profile
This heterozygous genotype is one of the common forms of this intergenic variant. Large-scale association studies have linked this site to complex trait architecture, though the functional impact of this specific variation is not yet fully understood. This information is for educational purposes and does not constitute medical advice.
This is a common genotype observed across diverse global populations.
Common genetic variant profile
This genotype is one of the common forms of this intergenic variant identified in population-level research. While this variant is associated with complex trait architecture in GWAS data, the exact biological role is currently uncertain. Please consult with a healthcare professional if you have specific health concerns related to your genetic profile.
This is a common genotype observed across diverse global populations.
Understanding rs947267 and Its Location
The rs947267 variant is a single nucleotide polymorphism (SNP), a common type of genetic variation where a single DNA letter differs between individuals. This specific SNP is situated within the DAOA (D-amino acid oxidase activator) gene region on chromosome 13. While many SNPs are located within genes that provide instructions for making proteins, the DAOA gene complex is known for its role in the body’s regulation of neurotransmission, particularly involving the glutamate system, which is critical for communication between neurons in the brain. Because this variant resides in a regulatory region, researchers often study it to understand if it influences how the DAOA gene is expressed or regulated. Variations in such regions are frequently investigated in association studies to see if they might contribute to complex traits where multiple genetic and environmental factors are at play. It is important to note that being located in a regulatory region does not inherently imply a functional impact on health.
Research and Statistical Associations
Over the past two decades, rs947267 has been a frequent subject of study in the field of psychiatric genetics. Numerous large-scale association studies and meta-analyses have investigated whether this variant influences susceptibility to complex psychiatric conditions, including schizophrenia and bipolar disorder. However, the evidence remains moderate and highly context-dependent. Some studies, particularly those involving Asian populations, have reported significant statistical associations between specific alleles of rs947267 and these conditions. Conversely, other researchers have failed to replicate these findings in different ethnic cohorts, such as European or Iranian populations. This inconsistency is common in complex trait genetics and may result from 'flip-flop' effects, where different alleles appear as the 'risk' factor in different groups, or because the variant is merely a proxy for a nearby, truly causal genetic factor that is inherited differently across ancestral backgrounds. Therefore, while rs947267 is a well-documented marker in the literature, it is not considered a definitive diagnostic tool for any condition.
What You Can and Cannot Do With This Information
It is important to remember that genetic associations are statistical observations, not medical diagnoses. Having a particular genotype does not determine your health outcomes. Because psychiatric conditions are complex and influenced by hundreds of genetic variants, environmental factors, and life experiences, a single SNP like rs947267 provides very little predictive information. You cannot use this variant to predict your personal risk of psychiatric illness. If you have concerns about your mental health or are curious about how your genetics may relate to your well-being, the best course of action is to speak with a healthcare professional or a genetic counselor. They can help you interpret information in the context of your overall health and family history. Never change your medication or dosing based on genetic information without first consulting your doctor or pharmacist, as they are the only ones qualified to make decisions about your clinical treatment.
How common is this variant?
The rs947267 variant is a common polymorphism found globally. Its frequency varies by ancestral background, which is a key reason why association studies often show different results depending on the population being examined.
Frequently asked questions
Is rs947267 a cause of schizophrenia or bipolar disorder?
No. Scientific studies have only identified statistical associations between this variant and these conditions in certain populations. These associations are often weak or inconsistent, meaning rs947267 is not considered a direct or primary cause of these disorders.
Can I use this SNP to predict my risk of psychiatric illness?
No, you cannot use this variant to predict psychiatric risk. Psychiatric conditions are complex and influenced by many factors; a single SNP like rs947267 provides very little predictive information.
Why do different studies report conflicting results for this SNP?
Conflicting results are common in genetic research due to differences in ancestral backgrounds, sample sizes, and study designs. Variations in linkage disequilibrium mean that a SNP may be associated with a trait in one population but not in another.
Should I change my medication based on this genotype?
No. Never change your medication or dosing based on genetic information without first consulting your doctor or pharmacist. They are the only ones qualified to make decisions about your clinical treatment.
Sources & further reading
Educational information only, last refreshed 10/4/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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