PCTP rs9907859: Genetic Markers and Jump Performance
The rs9907859 variant is a single nucleotide polymorphism located within the PCTP gene. It has been identified as a lead genetic marker associated with individual variations in how much an individual's countermovement jump height improves following a period of resistance training.
What each genotype means
Baseline jump enhancement
This genotype represents the major allele homozygote for the rs9907859 variant. Research indicates this variant is associated with individual differences in countermovement jump height improvement following resistance training, though this is a complex trait influenced by many genetic and environmental factors.
Based on a minor allele frequency of 0.16, this genotype is expected to be the most common in many populations, occurring in approximately 70% of individuals under Hardy-Weinberg equilibrium.
Potential jump enhancement variation
As a heterozygote for the rs9907859 variant, you carry one copy of the minor allele associated with differences in jump height response to resistance training. This genetic marker is one of several identified in studies of athletic performance, but it does not determine your physical potential on its own.
This genotype is estimated to occur in approximately 27% of the population, based on the reported minor allele frequency of 0.16.
Increased jump enhancement potential
This genotype represents the minor allele homozygote for the rs9907859 variant. Studies have identified this variant as a lead SNP associated with variations in how much an individual's countermovement jump height improves after a structured resistance training program. Please note that athletic performance is multifactorial and influenced by training, nutrition, and numerous other genetic factors.
This genotype is the least common, occurring in approximately 3% of the population based on the reported minor allele frequency of 0.16.
Understanding the rs9907859 Variant
The rs9907859 variant is a specific genetic location, or single nucleotide polymorphism (SNP), found on chromosome 17. In the context of human genomics, SNPs represent the most common type of genetic variation, where a single building block of DNA—a nucleotide—differs between individuals. Research has pinpointed rs9907859 as a lead variant within the PCTP gene region. This means that in genome-wide association studies (GWAS), this specific marker has shown a statistically significant correlation with a particular physical trait. By studying such markers, scientists aim to better understand the complex, polygenic nature of human physical performance and how different people respond to the same types of exercise stimuli. It is important to note that while this marker is statistically significant in research settings, it is one of many factors that contribute to athletic potential and training outcomes.
The Role of the PCTP Gene
The PCTP gene encodes the Phosphatidylcholine Transfer Protein. This protein is primarily known for its role in intracellular lipid metabolism, specifically facilitating the transfer of phosphatidylcholine between membranes. Phosphatidylcholine is a major component of cell membranes, and its proper distribution is essential for maintaining membrane integrity and function. Beyond its metabolic roles, recent research has begun to explore how PCTP might influence other physiological processes, including platelet activation. In the context of exercise science, the connection between lipid metabolism and muscle function is a subject of ongoing investigation. Because muscle contraction and adaptation to training involve complex energy demands and membrane remodeling, proteins involved in lipid transport are of interest to researchers studying the molecular mechanisms that drive physical performance and the varying degrees of success individuals experience when undergoing resistance training programs.
Evidence and Research Associations
The association between rs9907859 and countermovement jump (CMJ) height enhancement is grounded in recent genome-wide association study data. Researchers have observed that this variant, along with others in the same gene, shows a significant statistical relationship with the percentage change in jump height following structured resistance training. The evidence strength for this association is currently considered moderate, as it stems from specific studies investigating the genetic architecture of exercise trainability. It is crucial to understand that these findings describe population-level statistical associations rather than individual predictions. The biological mechanisms linking this specific SNP to jump performance are still being explored, and the effect size of any single variant is typically small. Because human physical performance is influenced by thousands of genetic variants, environmental factors, and training history, this SNP should be viewed as a small piece of a much larger, complex puzzle.
Practical Considerations for Consumers
If you encounter information about your genotype for rs9907859, it is important to maintain a balanced perspective. This genetic marker is a tool for scientific research into human physiology and exercise response, not a diagnostic test for athletic ability or a blueprint for training. You cannot use this information to determine your future success in sports or to dictate a specific exercise regimen. Genetic associations are based on averages across large groups of people and may not apply to your unique biology. If you are interested in optimizing your physical performance, the most effective approach remains working with qualified coaches, trainers, and healthcare professionals who can assess your current fitness level, goals, and health status. Do not make significant changes to your health or training routines based solely on genetic data. Always prioritize evidence-based training principles and consult with professionals who can provide personalized guidance tailored to your specific needs and safety.
How common is this variant?
The minor allele frequency (MAF) for the rs9907859 variant is approximately 0.16, indicating that the minor allele is present in about 16% of the studied population.
Frequently asked questions
Can I use rs9907859 to predict my athletic potential?
No, this variant cannot predict your athletic potential. It is a statistical marker associated with training response in research studies and does not account for the vast majority of factors that influence physical performance.
What does it mean if I have the G allele?
Having the G allele simply means you carry one of the common variations at this genetic location. It is not a 'good' or 'bad' gene, but rather a marker that researchers use to study how different people respond to exercise.
Should I change my workout routine based on this SNP?
No, you should not change your workout routine based on this SNP. Training programs should be designed by professionals based on your personal goals, current fitness level, and health, rather than individual genetic markers.
Is this genetic test medically diagnostic?
No, this variant is not used for medical diagnosis. It is a research-level association related to exercise physiology and has no clinical application for diagnosing health conditions.
Sources & further reading
Educational information only, last refreshed 9/25/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This SNP was identified as a genome-wide significant marker associated with training-induced improvements in athletic performance metrics.
This variant is associated with significant changes in jump height performance after structured strength training protocols.
A genome-wide significant variant linked to the biological mechanisms underlying individual responses to resistance training.