SLC5A2 rs9934336: What Your Genotype Means
The rs9934336 variant is a common genetic change located within the SLC5A2 gene, which encodes the SGLT2 protein. Research has explored its potential associations with heart failure risk, clinical outcomes, and responses to SGLT2 inhibitor medications.
What each genotype means
Typical SLC5A2 variant profile
This genotype is associated with variations in blood glucose and insulin concentrations. Research has linked this variant to differences in HbA1c levels and clinical outcomes in heart failure patients, though these effects are complex and may vary by individual health status. Please discuss any concerns regarding heart failure management or medication response with your clinician.
This is a common genotype found in many populations worldwide.
Typical SLC5A2 variant profile
This genotype is associated with variations in blood glucose and insulin concentrations. Research has linked this variant to differences in HbA1c levels and clinical outcomes in heart failure patients, though these effects are complex and may vary by individual health status. Please discuss any concerns regarding heart failure management or medication response with your clinician.
This is a common genotype found in many populations worldwide.
Typical SLC5A2 variant profile
This genotype is associated with variations in blood glucose and insulin concentrations. Research has linked this variant to differences in HbA1c levels and clinical outcomes in heart failure patients, though these effects are complex and may vary by individual health status. Please discuss any concerns regarding heart failure management or medication response with your clinician.
This is a common genotype found in many populations worldwide.
Understanding the rs9934336 Variant
The rs9934336 variant is a single nucleotide polymorphism (SNP) situated in the first intron of the SLC5A2 gene. In genetics, an intron is a non-coding region of DNA that lies between the coding sequences, or exons, of a gene. While introns do not directly provide the instructions for building a protein, they can play critical roles in regulating how genes are expressed. Because rs9934336 is located in this regulatory region, researchers have investigated whether it influences the activity or production levels of the SGLT2 protein. Currently, the precise molecular mechanism by which this specific variant might alter gene function remains a subject of ongoing scientific study, and its exact biological impact is not yet fully understood.
The Role of the SLC5A2 Gene
The SLC5A2 gene provides the instructions for creating the sodium-glucose cotransporter 2 (SGLT2) protein. This protein is primarily found in the kidneys, where it is responsible for reabsorbing glucose from the urine back into the bloodstream. By regulating this process, SGLT2 plays a significant role in maintaining blood sugar balance. In recent years, SGLT2 has become a major target for medical therapy. Medications known as SGLT2 inhibitors, such as dapagliflozin and empagliflozin, work by blocking this transporter, which helps lower blood glucose levels in people with type 2 diabetes. Beyond glucose control, these medications have demonstrated significant benefits in managing heart failure, leading to extensive research into how genetic variations in the SLC5A2 gene might influence both the disease process and the effectiveness of these treatments.
Research and Clinical Associations
Scientific studies have examined the relationship between rs9934336 and various health outcomes, particularly heart failure. Some research has suggested that this variant may be associated with a trend toward a reduced risk of developing heart failure and has been linked to lower levels of NT-proBNP, a biomarker often used to assess heart health. However, the evidence regarding its impact on medication response is mixed. While some studies have investigated whether this variant influences how patients respond to SGLT2 inhibitors like dapagliflozin, results have been inconsistent, with some trials finding no statistically significant association between the variant and changes in clinical markers like HbA1c or blood pressure. Because the evidence is currently limited and sometimes conflicting, this variant is not used to guide clinical decision-making at this time.
What This Information Means for You
It is important to understand that genetic associations are statistical observations across large populations and do not predict individual health outcomes. Having a specific genotype for rs9934336 does not mean you will or will not develop a condition, nor does it guarantee how you will respond to a specific medication. If you are currently taking SGLT2 inhibitors or are concerned about heart failure, you should never make changes to your treatment plan based on genetic information alone. Always discuss your medications, dosages, and any genetic testing results with your healthcare provider or a clinical pharmacist. They are the only ones qualified to interpret how your unique genetic profile, medical history, and current health status should inform your personalized care plan.
How common is this variant?
The rs9934336 variant is considered a common polymorphism, with its specific allele frequencies varying across different global ancestral populations.
Frequently asked questions
Does the rs9934336 variant mean I have heart failure?
No. This variant is a common genetic marker that has been studied for its statistical association with heart failure risk in large populations. It is not a diagnostic test for heart failure.
Can I use this SNP to see if dapagliflozin will work for me?
Current research has not provided consistent evidence that rs9934336 can reliably predict how an individual will respond to dapagliflozin. You should rely on your doctor's clinical assessment rather than genetic testing for medication management.
Is rs9934336 the same as a mutation?
In genetics, a variant like rs9934336 is often called a polymorphism because it is common in the population. Unlike rare mutations that cause specific genetic disorders, this variant is a normal variation in the human genome.
Should I get tested for this variant?
There is currently no clinical recommendation to test for this variant. Because the evidence regarding its impact on health and treatment is limited and mixed, it does not provide actionable information for your medical care.
Sources & further reading
Educational information only, last refreshed 10/27/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant in the SLC5A2 gene is associated with clinical outcomes and response to dapagliflozin in patients with heart failure.
This SNP in the SLC5A2 gene has been identified as a factor influencing clinical outcomes in patients treated with SGLT2 inhibitors.