LOC130067884 rs131756: What Your Genotype Means
The genetic variant rs131756 is a single nucleotide polymorphism (SNP) located within the LOC130067884 gene region. Research has identified this non-coding variant as being associated with differences in protein measurement levels in human populations.
What each genotype means
Typical protein measurement levels
This genotype is considered the baseline for this non-coding variant. Research indicates this variant is associated with differences in protein measurement levels, though the specific functional impact of this genotype remains under investigation.
Population frequency data for this specific genotype is not currently recorded in public databases.
Varied protein measurement levels
Carrying one copy of the variant allele may be associated with differences in protein measurement levels compared to the baseline. As this is a non-coding variant, its influence on protein levels is likely regulatory, though the exact biological mechanism is not fully understood.
Population frequency data for this specific genotype is not currently recorded in public databases.
Varied protein measurement levels
Carrying two copies of the variant allele is associated with differences in protein measurement levels in some studies. This variant is located in a non-coding region that may function as a regulatory element, but the clinical significance of this genotype is currently classified as benign.
Population frequency data for this specific genotype is not currently recorded in public databases.
Understanding rs131756
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs131756 is classified as a non-coding SNP, meaning it is located in a region of the genome that does not provide instructions for making proteins directly. Instead, such variants often reside in regulatory regions that may influence how genes are turned on or off. In the case of rs131756, it is situated within the genomic coordinates associated with the LOC130067884 gene. Because it is non-coding, it does not alter the amino acid sequence of a protein, but it may still play a role in the complex regulatory networks that control biological processes within the cell.
The Role of LOC130067884
The gene LOC130067884 is a locus identified in the human genome that is currently the subject of ongoing functional research. While its specific biological function is still being characterized by the scientific community, it has been identified as a site containing chromatin-accessible regions, which are areas of DNA that are open and available for regulatory proteins to bind. Studies, such as those utilizing ATAC-STARR-seq, have investigated these regions to determine if they act as enhancers or silencers of gene expression. Understanding the function of such loci is a primary goal of modern genomics, as these regions often house the 'switches' that dictate how our genetic code is interpreted in different tissues and under various environmental conditions.
Research Associations and Evidence
The association between rs131756 and protein measurement levels has been documented in the GWAS Catalog, a comprehensive resource of genome-wide association studies. In these studies, researchers look for statistical correlations between specific genetic variants and measurable traits across large groups of people. The evidence for this specific association is currently considered moderate. It is important to note that a statistical association in a GWAS does not necessarily imply that the variant causes the trait directly; rather, it suggests that the variant is located in a region of the genome that may influence the trait. As with many non-coding variants, the exact mechanism by which rs131756 might influence protein levels remains an area of active investigation, and findings can vary depending on the population studied.
Interpreting Your Genetic Information
When you encounter information about variants like rs131756, it is helpful to understand that this data is intended for educational purposes. Because this variant is associated with protein measurement levels in a research context, it is not a diagnostic tool for any medical condition. You cannot use this information to predict health outcomes or make decisions about your medical care. If you have questions about your health or specific laboratory results, the most appropriate step is to consult with a qualified healthcare professional. They can help you interpret your health data in the context of your overall medical history, lifestyle, and other clinical factors, ensuring that any decisions are based on comprehensive and personalized medical advice.
How common is this variant?
There is currently no specific population frequency data recorded for the rs131756 variant in major public databases. Frequency can vary significantly across different ancestral groups.
Frequently asked questions
What is rs131756?
rs131756 is a specific genetic variant, or SNP, located in the LOC130067884 gene region. It is a non-coding variant that has been statistically linked to differences in protein measurement levels.
Is rs131756 associated with a disease?
Currently, rs131756 is associated with protein measurement levels in research studies. It is not classified as a disease-causing variant, and it is listed as benign in clinical databases like ClinVar.
Can I use this information to diagnose a health condition?
No, this information is for educational purposes only. It cannot be used to diagnose any medical condition, and you should always consult a doctor for health-related concerns.
Where can I find more information about this variant?
You can find more information through resources like the GWAS Catalog, dbSNP, and ClinVar. These databases provide curated data on genetic variants and their reported associations.
Sources & further reading
Educational information only, last refreshed 9/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs131756?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29