rs145088108: Understanding Native American Haplotypes and MS Risk
The genetic variant rs145088108 is a specific DNA marker that has been identified as having a significant association with an increased risk of multiple sclerosis (MS). This association is observed specifically within individuals carrying Native American genetic haplotypes.
What each genotype means
Baseline risk profile
This genotype represents the common ancestral state at this position. Research indicates that the alternative allele is associated with increased multiple sclerosis risk specifically in Native American haplotypes, meaning this genotype does not carry that specific risk association. This result does not rule out other genetic or environmental factors contributing to health outcomes.
This is the most common genotype in most global populations, though its frequency varies significantly by ancestry.
Potential risk association
This genotype includes one copy of the variant associated with increased multiple sclerosis risk in individuals of Native American ancestry. Because this association is ancestry-specific, the clinical relevance depends heavily on your genetic background. Please consult with a healthcare provider to discuss how this information fits into your overall health context.
This genotype is found primarily in populations with Native American ancestry and is rare or absent in many other global populations.
Increased risk association
This genotype includes two copies of the variant associated with increased multiple sclerosis risk in individuals of Native American ancestry. This association is specific to certain ancestral haplotypes, and the actual risk may be influenced by other genetic and environmental factors. This finding is not a diagnosis; please discuss these results with a clinician to understand their significance for your health.
This genotype is observed at low frequencies and is largely restricted to individuals with Native American genetic ancestry.
What is rs145088108?
The identifier rs145088108 refers to a specific single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This variant is located in an intergenic region, meaning it sits in the space between genes rather than within a gene that codes for a protein. Because it is intergenic, it does not directly alter the structure of a protein. Instead, researchers investigate such variants to see if they influence how nearby genes are turned on or off, or if they serve as markers for other nearby genetic changes that may contribute to disease susceptibility. In the context of complex conditions like multiple sclerosis, these markers help scientists map the genetic architecture of the disease across different ancestral backgrounds.
Research and Evidence Strength
Current research identifies rs145088108 as a variant significantly associated with multiple sclerosis risk, particularly in populations with Native American ancestry. The evidence for this association is considered moderate, as it emerged from studies focusing on the genetic diversity of MS risk in admixed populations, such as Hispanic and African American cohorts. These studies utilize admixture mapping to pinpoint regions of the genome where specific ancestral contributions correlate with disease status. While the statistical association is notable, it is important to recognize that MS is a polygenic disease, meaning it is influenced by many different genetic variants, environmental factors, and their interactions. The discovery of this variant highlights the importance of studying diverse populations to fully understand the genetic landscape of MS, as many risk factors identified in European-centric studies do not fully account for the disease risk in other ancestral groups.
Understanding Ancestry-Specific Risk
The association of rs145088108 is described as ancestry-specific, meaning its impact on MS risk is tied to the genetic background of the individual. Genetic ancestry refers to the historical geographic origins of an individual's ancestors, which are reflected in their DNA. Because different populations have unique evolutionary histories, they may carry different genetic variants that influence disease risk. In the case of rs145088108, the variant is found on Native American haplotypes—blocks of DNA inherited together from a common ancestor. This does not mean that the variant causes MS on its own, but rather that it is a marker that appears more frequently in individuals who develop the condition within this specific ancestral context. Researchers continue to study these haplotypes to determine if the variant is a direct contributor to the inflammatory processes involved in MS or if it is simply a reliable indicator of other underlying genetic factors.
What This Information Means for You
It is essential to understand that having a specific genetic variant does not mean an individual will develop multiple sclerosis. Genetic risk factors are probabilistic, not deterministic. This information is primarily used by researchers to better understand the biological mechanisms of MS and to improve the accuracy of genetic risk models across diverse populations. If you are concerned about your health or family history of MS, this information should not be used for self-diagnosis or to make medical decisions. Genetic testing for such variants is not a standard diagnostic tool for MS. If you have questions about your health, symptoms, or the role of genetics in your family, please consult with a qualified healthcare provider or a genetic counselor. They can provide context based on your personal medical history and guide you through appropriate clinical evaluations.
How common is this variant?
The frequency of rs145088108 is highly ancestry-specific, appearing primarily in individuals with Native American genetic backgrounds. It is not a common variant in populations of purely European or African descent.
Frequently asked questions
Does having this variant mean I will get MS?
No. Genetic variants associated with MS only indicate a statistical increase in risk, not a certainty of developing the disease. Most people with risk variants never develop the condition.
Can I get tested for rs145088108?
While this variant can be identified through research-grade genotyping, it is not a standard clinical test. It is not used by doctors to diagnose or predict MS in a clinical setting.
Why is this variant only found in Native American haplotypes?
Genetic variants often arise and persist within specific populations due to their unique evolutionary history and ancestral migration patterns. This variant is a marker that tracks with the specific genetic heritage of Native American populations.
What should I do if I have a family history of MS?
If you have a family history of MS, the best course of action is to speak with a neurologist or a genetic counselor. They can assess your personal risk based on clinical factors rather than focusing on individual genetic markers.
Sources & further reading
Educational information only, last refreshed 10/27/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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