CLOCK rs207006: What Your Genotype Means
The rs207006 variant is a single nucleotide polymorphism located within the CLOCK gene. It has been studied for its potential association with variations in human sleep duration.
What each genotype means
Typical sleep duration profile
This genotype is generally associated with standard sleep duration patterns in population studies. It does not carry the specific association with shorter sleep duration observed in carriers of the alternative allele.
This is a common genotype found in many populations worldwide.
Typical sleep duration profile
Individuals with this genotype typically show sleep patterns consistent with the general population. Research has not identified a strong, consistent link between this heterozygous state and significant deviations in sleep duration.
This is a common genotype observed across various ancestral groups.
Potential shorter sleep duration
Some research indicates that this genotype may be associated with shorter self-reported sleep duration. These associations are statistical in nature and reflect population-level trends rather than a guaranteed individual outcome.
This genotype is common, appearing in a significant portion of the population.
Understanding the rs207006 Variant
The rs207006 variant is a specific genetic change, or single nucleotide polymorphism (SNP), found within the CLOCK gene. The CLOCK gene, which stands for Circadian Locomotor Output Cycles Kaput, plays a fundamental role in regulating the body's internal biological clock. This internal system, often called the circadian rhythm, governs essential physiological processes, including the sleep-wake cycle, hormone secretion, and metabolic homeostasis. Because the CLOCK gene is a core component of this molecular machinery, researchers frequently investigate variants within it to understand how subtle genetic differences might influence individual differences in circadian behavior. The rs207006 SNP is one of many markers used by scientists to map the complex relationship between our inherited DNA and the timing of our daily biological functions.
The Role of the CLOCK Gene
The CLOCK gene encodes a transcription factor that acts as a primary driver of the circadian rhythm. By forming complexes with other proteins, such as BMAL1, it initiates the transcription of various genes that control the 24-hour cycle of cellular activity. This molecular clock is not just limited to the brain; it exists in nearly every tissue of the body, helping to synchronize metabolic pathways, glucose regulation, and lipid homeostasis. When the function of the CLOCK gene is altered, it can theoretically impact the precision of these rhythms. Because sleep is a primary output of the circadian system, variations in the CLOCK gene are of significant interest to sleep researchers. Understanding how this gene functions provides a window into why individuals may have different natural preferences for sleep timing and duration.
Research Associations and Evidence
Scientific research has explored the link between rs207006 and sleep-related traits. Some studies, such as those conducted within the Jackson Heart Study, have reported associations between specific CLOCK gene variants and self-reported sleep duration. In these population-based studies, researchers look for statistical correlations between the presence of a specific allele and the average number of hours participants report sleeping. It is important to note that the evidence for these associations is considered moderate. While some studies have identified significant links, others have found that these associations may vary depending on the ancestry of the study population or may not remain significant after rigorous statistical correction for multiple testing. Consequently, while rs207006 is a marker of interest, it is not a definitive predictor of an individual's sleep habits, as sleep is a complex trait influenced by many genes and environmental factors.
Population Frequency and Interpretation
The rs207006 variant is considered a common SNP, meaning it is found at a relatively high frequency across various human populations. Because it is common, many people carry one or both copies of the variant allele. When interpreting this information, it is crucial to remember that genetic associations are statistical in nature. They describe trends observed in large groups of people rather than providing a specific diagnosis for an individual. Having a particular genotype does not mean you will experience a specific sleep duration, nor does it account for the significant impact of lifestyle, stress, and environment on sleep quality. This information is intended for educational purposes to help you understand the current state of genetic research. It should not be used to make medical decisions or to diagnose sleep disorders.
How common is this variant?
The rs207006 variant is a common polymorphism, with its genotypes appearing frequently across diverse global populations.
Frequently asked questions
Does my rs207006 genotype mean I have a sleep disorder?
No. Genetic associations with sleep duration are statistical trends observed in large populations and do not constitute a medical diagnosis. Sleep disorders are complex conditions that require evaluation by a healthcare professional.
Can I use this information to change my sleep schedule?
Genetic information should not be used to guide medical or lifestyle changes without consulting a doctor. If you are concerned about your sleep, speak with a clinician about evidence-based strategies for sleep hygiene.
Is the association between rs207006 and sleep strong?
The evidence for this association is considered moderate. While some studies have found statistical links, these results can vary between populations and are often subject to complex environmental influences.
Where can I learn more about the CLOCK gene?
You can find reliable information about the CLOCK gene and its role in circadian rhythms through resources like MedlinePlus Genetics or by searching for peer-reviewed studies on PubMed.
Sources & further reading
Educational information only, last refreshed 11/4/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant in the CLOCK gene is associated with variations in circadian rhythm, chrononutrition, and metabolic parameters in adolescents.
Polymorphism in the CLOCK gene linked to sleep disturbances and metabolic health markers in adolescent populations.
Carriers of the T allele are associated with significantly shorter sleep duration.
Widely studied 3-prime UTR single nucleotide polymorphism (3111T/C) in CLOCK that influences individual evening chronotype, delayed sleep timing, and daytime sleepiness.
A 3-UTR single nucleotide polymorphism in the core CLOCK gene associated with evening chronotype.
3' UTR polymorphism in the core circadian regulator gene associated with evening chronotype ('night owl' tendency) and delayed sleep phase.