CD6 rs929230: Understanding This Genetic Variant
The rs929230 variant is a common single nucleotide polymorphism located on chromosome 11. It has been studied for its potential statistical associations with various health-related traits, including multiple sclerosis.
What each genotype means
Baseline risk profile
This genotype represents the common baseline for this variant. Research has not identified a significant association between this specific combination and increased disease risk compared to the general population.
This is a common genotype found in the general population.
Baseline risk profile
This genotype represents a common variation at this position. There is no established evidence suggesting that carrying one copy of the G allele significantly alters disease risk compared to the baseline.
This is a common genotype found in the general population.
Potential multiple sclerosis association
Some research has observed that this genotype is associated with a slightly reduced odds ratio (0.92x) of developing multiple sclerosis. This finding is based on statistical associations in specific study populations and does not constitute a medical diagnosis or a guarantee of health outcomes.
This is a common genotype found in the general population.
What is rs929230?
The rs929230 variant is a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This specific SNP is located on chromosome 11 at position 60,993,499 (GRCh38). In the context of the human genome, rs929230 is situated in the vicinity of the CD6 gene. SNPs are the most common type of genetic variation among people, and they often serve as biological markers that help researchers locate genes associated with specific health conditions. Because rs929230 is located in a region near the CD6 gene, it is frequently analyzed in studies investigating immune system function and related inflammatory processes.
The Role of the CD6 Gene
The CD6 gene encodes a protein that is primarily expressed on the surface of T cells, which are a critical component of the human immune system. The CD6 protein acts as a co-stimulatory receptor, meaning it helps regulate the activation and signaling of T cells. By modulating these signals, CD6 plays a significant role in the immune response, helping the body distinguish between healthy cells and potential threats. Because of its involvement in T cell activity, variations in or near the CD6 gene are of interest to scientists studying autoimmune diseases, where the immune system may mistakenly target the body's own tissues. Research into this gene continues to evolve as scientists seek to understand how its expression influences immune-mediated conditions.
Research and Associations
Scientific research has investigated the potential link between rs929230 and various health traits. Notably, some studies, such as those reported by the DeCode project, have explored the association between the GG genotype of rs929230 and the risk of developing multiple sclerosis. It is important to note that these findings represent statistical associations observed in specific study populations rather than a direct cause-and-effect relationship. The evidence strength for these associations is generally considered moderate, and results can vary based on the ancestry and environmental factors of the populations studied. Genetic associations are complex, and having a particular genotype does not guarantee the development of any condition. Researchers continue to conduct large-scale genome-wide association studies (GWAS) to better understand the clinical significance of this variant.
Interpreting Your Genetic Information
Understanding your genetic data requires careful consideration of the limitations of current science. While SNPs like rs929230 provide valuable insights into human biology, they are only one piece of a much larger puzzle that includes lifestyle, environment, and other genetic factors. You cannot use this information to diagnose yourself or predict future health outcomes with certainty. If you have concerns about your health or are interested in how your genetics might influence your risk for specific conditions, the most appropriate step is to consult with a qualified healthcare professional or a genetic counselor. They can help you interpret your results in the context of your personal and family medical history and provide guidance on appropriate screenings or lifestyle adjustments.
How common is this variant?
The rs929230 variant is considered a common polymorphism, with a Global Minor Allele Frequency (GMAF) reported at approximately 0.1116 in major databases.
Frequently asked questions
Is rs929230 a diagnostic test for multiple sclerosis?
No, rs929230 is not a diagnostic test. It is a genetic marker associated with statistical risk in research studies, and it cannot be used to diagnose or rule out multiple sclerosis in an individual.
What should I do if I have the G/G genotype?
The G/G genotype is a common genetic variation. You should not take any medical action based on this result; instead, focus on maintaining a healthy lifestyle and discuss any specific health concerns with your doctor.
Where can I find more information about my specific genetic results?
You can consult with a board-certified genetic counselor who can help you understand the clinical relevance of your genetic data. They are trained to explain complex genetic information in the context of your personal health.
Are all genetic associations permanent?
Genetic associations are based on current scientific research, which is constantly evolving. As more data is collected and analyzed, our understanding of how specific variants influence health may change or become more refined.
Sources & further reading
Educational information only, last refreshed 10/6/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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