rs933399: Understanding This Genetic Variant and Its Associations
The genetic variant rs933399 is a single-nucleotide polymorphism located on chromosome 12. It has been identified in scientific literature for its potential statistical association with bipolar affective disorder.
What each genotype means
Baseline genetic profile
This genotype represents the baseline state for this variant as documented in genomic databases. Current research indicates this variant is associated with various health-related traits, though specific clinical implications for this genotype remain under investigation.
Frequency data for this specific genotype varies significantly by ancestral background and is not universally established.
Baseline genetic profile
This heterozygous genotype is documented in genomic databases as part of the natural variation at this location. As this is an intergenic variant with moderate evidence for trait association, the presence of one copy of each allele does not currently indicate a specific clinical condition.
Frequency data for this specific genotype varies significantly by ancestral background and is not universally established.
Baseline genetic profile
This genotype is a common variation observed in human populations at this genomic position. While this variant is cataloged for potential associations with health-related traits, there is no definitive evidence linking this specific genotype to a clinical diagnosis.
Frequency data for this specific genotype varies significantly by ancestral background and is not universally established.
What is rs933399 and where is it located?
The variant rs933399 is a single-nucleotide polymorphism, or SNP, which is a common type of genetic variation where a single building block of DNA—a nucleotide—is replaced by another. This specific SNP is located on chromosome 12 at position 111,369,695. It is situated within the genomic region associated with the FAM109A gene. In the context of human genetics, SNPs like rs933399 are often studied to determine if they correlate with specific physical traits or health conditions. Because this variant is located in an intergenic or gene-proximal region, researchers investigate whether it might influence the regulation or expression of nearby genes, potentially impacting biological pathways. It is important to note that the presence of a SNP does not inherently cause a condition; rather, it serves as a marker that scientists use to map areas of the genome that may contribute to complex human traits.
Research and Associations
Scientific research has explored the potential link between rs933399 and bipolar affective disorder. Specifically, studies have investigated whether this variant, often in conjunction with other markers like rs3847953, shows evidence of linkage disequilibrium—a phenomenon where certain alleles are inherited together more frequently than would be expected by chance. While some early linkage mapping studies provided evidence for an association at this chromosomal locus, it is crucial to understand that the evidence strength for this specific variant is considered moderate. Complex conditions like bipolar disorder are polygenic, meaning they are influenced by the interaction of many different genetic variants, environmental factors, and lifestyle elements. Consequently, a single SNP like rs933399 typically has a very small individual effect size. Current genomic databases continue to track these associations to better understand the architecture of psychiatric traits, but these findings are generally intended for research purposes rather than clinical prediction.
What you can and cannot do with this information
Information regarding genetic variants like rs933399 is primarily intended for educational and research purposes. It is vital to recognize that having a particular genotype at this location does not constitute a medical diagnosis or a prediction of future health outcomes. Genetic associations identified in large-scale studies represent statistical correlations across populations, not individual certainties. If you are concerned about your mental health or have questions about your family history, you should consult with a qualified healthcare professional or a genetic counselor. They can provide context based on your personal health history and clinical symptoms, which are far more significant than any single genetic marker. Never use information from genetic databases to make decisions about your medical care, such as starting or stopping medications, without first discussing these topics with your clinician or pharmacist.
How common is this variant?
The global minor allele frequency for rs933399 is approximately 0.4169, indicating that the variant is relatively common across diverse human populations.
Frequently asked questions
Is rs933399 a diagnostic test for bipolar disorder?
No, rs933399 is not a diagnostic test. Bipolar disorder is a complex condition influenced by many genetic and environmental factors, and no single SNP can determine if an individual will develop the condition.
Where can I find more information about this SNP?
You can explore resources like the GWAS Catalog, dbSNP, and SNPedia. These databases provide curated information on published research and the genomic location of various variants.
Should I change my medication based on my genotype?
No. You should never change your medication or treatment plan based on genetic information without consulting your doctor or pharmacist. Always discuss your health concerns with a medical professional.
What does 'moderate evidence' mean in genetics?
Moderate evidence typically means that while some studies have observed a statistical association, the findings may not be definitive or consistent across all populations. It suggests that more research is needed to confirm the role of the variant.
Sources & further reading
Educational information only, last refreshed 10/6/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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