MEIS1 rs11145926: What Your Genotype Means
The rs11145926 variant is a common genetic change located within the MEIS1 gene. It is widely recognized in scientific literature as a robustly replicated genetic risk factor associated with restless legs syndrome (RLS) and periodic limb movements of sleep.
What each genotype means
Typical risk profile
You carry two copies of the common C allele at rs11145926. In genome-wide association studies, this baseline genotype is not associated with an elevated likelihood of developing restless legs syndrome or periodic limb movements in sleep. However, non-genetic contributors and other genomic loci can still influence sleep and limb sensations.
Found in approximately 40% to 45% of individuals of European ancestry and is more frequent in East Asian and African populations.
Moderately increased risk
You carry one copy of the T risk allele at this MEIS1 intronic marker. Population studies indicate a moderate statistical increase in susceptibility to restless legs syndrome and nocturnal periodic limb movements compared to non-carriers. This finding represents a modest relative risk factor rather than a medical diagnosis.
Carried by approximately 45% of individuals of European descent, with lower frequencies observed in African and East Asian ancestries.
Increased risk profile
You carry two copies of the T risk allele at rs11145926 in MEIS1. Research correlates this homozygous genotype with the highest relative predisposition among rs11145926 genotypes for restless legs syndrome and involuntary periodic leg movements during sleep. Because this variant accounts for only a fraction of overall genetic liability, carrying it does not mean you will definitely develop these conditions.
Present in roughly 10% to 15% of European populations and substantially less frequent in individuals of East Asian ancestry.
Understanding the Variant
The rs11145926 variant is a single nucleotide polymorphism (SNP) situated within the MEIS1 gene. In genetics, an intronic variant like this one resides in a non-coding region of the gene, meaning it does not directly alter the protein sequence itself. Instead, such variants often influence how a gene is turned on or off, or how much of a protein is produced in specific tissues. Research indicates that this specific locus is part of a larger genomic region that has been consistently identified through genome-wide association studies (GWAS) as a major susceptibility site for sleep-related movement disorders. Because it sits in a regulatory area, scientists study it to understand how it might disrupt the normal expression of the MEIS1 gene during development or in the adult nervous system.
The Role of the MEIS1 Gene
The MEIS1 gene encodes a transcription factor, which is a protein that helps control the activity of other genes. Transcription factors act like master switches, turning sets of genes on or off to guide cell development and function. In the context of the nervous system, MEIS1 is crucial for the specification and development of neuronal progenitors. Studies in animal models, such as mice, have shown that a deficiency in MEIS1 can lead to hyperactivity and movement patterns that resemble the symptoms of restless legs syndrome in humans. Furthermore, research suggests that MEIS1 plays a role in maintaining iron homeostasis within the brain. Since iron metabolism is closely linked to the underlying biology of RLS, the influence of MEIS1 on these pathways is a primary focus of ongoing neurological research.
Research and Evidence Strength
The association between MEIS1 variants and restless legs syndrome is considered one of the most robust findings in the genetics of sleep disorders. Multiple large-scale studies have replicated the link between common variants in this region and an increased risk of developing RLS. While the statistical association is strong, the evidence is categorized as limited in terms of clinical utility because having the variant does not guarantee that an individual will develop the condition. RLS is a complex, multifactorial trait influenced by both genetic and environmental factors. Current research is focused on how these intronic variants alter enhancer function in the brain, specifically in the telencephalon, to better understand the biological mechanism. It is important to note that while this variant is a significant risk factor, it is only one piece of a much larger genetic puzzle.
Population Frequency
The rs11145926 variant is found at a high frequency in European populations, making it a widely studied marker in genetic research. Because it is a common variant, a significant portion of the general population carries at least one copy of the risk-associated allele. The prevalence of RLS itself varies, but it is generally estimated to affect between 3.9% and 14.3% of the adult population, with higher rates observed in North American and European cohorts. The frequency of this specific SNP is consistent with its status as a common susceptibility allele rather than a rare mutation. Researchers often use these high-frequency variants to conduct large-scale association studies, as they provide enough statistical power to detect modest increases in risk across diverse groups.
What This Information Means for You
Genetic information regarding the rs11145926 variant is intended for educational purposes and should not be used for medical diagnosis. Carrying this variant does not mean you have or will develop restless legs syndrome, nor does the absence of it guarantee you will not. RLS is diagnosed based on clinical symptoms, such as an uncomfortable urge to move the legs, typically occurring at rest or during the evening. If you are experiencing symptoms that affect your sleep or quality of life, it is important to consult with a healthcare professional. They can evaluate your symptoms, check for underlying issues like iron deficiency, and discuss appropriate management strategies. Never use genetic test results to make decisions about your health or to alter any prescribed treatments without first speaking to your doctor or a qualified medical provider.
How common is this variant?
The rs11145926 variant is highly prevalent in European populations, where it is frequently studied as a major risk locus for restless legs syndrome.
Frequently asked questions
Does having the MEIS1 variant mean I have restless legs syndrome?
No, having this variant does not mean you have RLS. It is a genetic risk factor, meaning it may increase the statistical likelihood of developing the condition, but it is not a diagnostic test.
Can I use this genetic information to diagnose myself?
You should never use genetic information to diagnose yourself. RLS is a clinical diagnosis made by a doctor based on your symptoms and medical history, not by a genetic test.
Is there a cure for RLS if I have this genetic variant?
There is no genetic cure for RLS. Management typically involves lifestyle changes and addressing underlying factors like iron levels, which should be discussed with a healthcare provider.
Why is MEIS1 linked to iron levels?
Research suggests that MEIS1 plays a role in regulating iron homeostasis in the brain. Since iron deficiency is a known trigger for RLS symptoms, the gene's influence on iron pathways is a key area of study.
Sources & further reading
Educational information only, last refreshed 10/27/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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A fine-mapped regulatory variant within the MEIS1 locus associated with restless legs syndrome and periodic limb movements during sleep.
This intronic regulatory variant in MEIS1 is a primary risk locus for restless legs syndrome, influencing gene expression in the developing telencephalon.
Intronic SNP strongly predisposing individuals to Restless Legs Syndrome and periodic limb movements during sleep.
Intronic regulatory variant within MEIS1 strongly implicated in periodic limb movements during sleep and restless legs syndrome etiology.
A 3' UTR variant in MEIS1 associated with periodic limb movement in sleep, restless legs syndrome, and insomnia symptoms.
Non-coding regulatory variant in MEIS1 that is strongly associated with periodic limb movements during sleep and symptom severity in restless legs syndrome.