MEIS1 rs7359837: What Your Genotype Means
The rs7359837 variant is a genetic marker located within the MEIS1 gene, which has been identified by researchers as a significant factor in the risk for Restless Legs Syndrome (RLS). This intronic SNP is associated with periodic limb movements during sleep and may influence how the MEIS1 gene is expressed in the brain.
What each genotype means
Typical risk profile
You carry two copies of the major non-risk allele for this MEIS1 intronic variant. In published genome-wide association studies, this genotype is not associated with elevated genetic susceptibility to restless legs syndrome or periodic limb movements during sleep. However, non-genetic and lifestyle factors such as iron levels and sleep habits still contribute significantly to sleep health.
Carried by approximately 30% to 40% of individuals in European and East Asian populations.
Moderately increased RLS risk
You carry one copy of the G risk allele at rs7359837 within the MEIS1 gene. Research indicates that heterozygosity at this locus is associated with a moderate increase in population-level odds of developing restless legs syndrome and periodic limb movements in sleep. This is a statistical risk factor rather than a medical diagnosis, and many carriers never develop symptoms.
Carried by approximately 45% to 50% of individuals across European and East Asian populations.
Elevated RLS risk
You carry two copies of the G risk allele at rs7359837 within the MEIS1 gene. Studies associate this homozygous genotype with the highest genetic odds of restless legs syndrome and periodic limb movements during sleep observed at this locus. While this genotype increases vulnerability, restless legs syndrome is a complex condition influenced by additional genetic, metabolic, and environmental factors.
Carried by roughly 15% to 20% of individuals in European and East Asian populations.
Understanding the rs7359837 Variant
The rs7359837 variant is a single nucleotide polymorphism (SNP) situated within the MEIS1 gene. In genetics, an intronic SNP like this one is located in a non-coding region of the gene, meaning it does not directly change the protein sequence produced by the gene. Instead, such variants often function as regulatory elements that influence when, where, and how much of a specific protein is produced. Research indicates that this specific location is highly conserved across species, suggesting it plays a critical role in biological function. Scientists study these variants to understand how subtle changes in our DNA sequence can contribute to complex traits and conditions, such as sleep disorders. By mapping these markers, researchers aim to uncover the underlying biological pathways that lead to symptoms like those seen in Restless Legs Syndrome.
The Role of the MEIS1 Gene
The MEIS1 gene encodes a transcription factor, which is a protein that acts like a master switch to turn other genes on or off. This process is essential for normal development, particularly in the nervous system. Beyond its developmental role, MEIS1 has been implicated in the regulation of iron metabolism and the maintenance of healthy sleep patterns. Because iron deficiency is a well-known clinical factor in Restless Legs Syndrome, the link between MEIS1 and iron regulation is a major focus of current scientific inquiry. When MEIS1 expression is altered, it may disrupt the delicate balance required for normal neurological function during sleep. Understanding this gene's function helps researchers bridge the gap between genetic risk factors and the physical symptoms experienced by individuals with sleep-related conditions.
Research and Evidence Strength
Genome-wide association studies (GWAS) have consistently identified the MEIS1 locus as a robust genetic risk factor for Restless Legs Syndrome (RLS). While the association between variants in this region and RLS is well-documented in scientific literature, the evidence regarding the specific functional impact of rs7359837 is considered limited. Most studies confirm that risk-associated haplotypes in this gene are linked to decreased levels of MEIS1 mRNA and protein expression, which may contribute to disease susceptibility. However, because RLS is a complex condition influenced by both genetic and environmental factors, having a specific genotype does not guarantee the development of the condition. Further research is required to fully elucidate the precise mechanisms by which this SNP influences sleep architecture and to determine its clinical utility in predictive medicine.
Population Frequency
The rs7359837 variant is relatively common, with a minor allele frequency typically ranging between 0.35 and 0.45 across various European and Asian populations. This high frequency suggests that the variant is a widespread feature of the human genome rather than a rare mutation. Because it is so common, many individuals carry at least one copy of the risk-associated allele without ever experiencing symptoms of Restless Legs Syndrome. This highlights the fact that genetic predisposition is only one piece of a much larger puzzle that includes lifestyle, iron levels, and other genetic modifiers. Population-level data from projects like gnomAD are essential for researchers to understand how these frequencies vary across different ancestral backgrounds and to refine our understanding of the global distribution of this genetic marker.
What This Information Means for You
It is important to recognize that genetic variants like rs7359837 are statistical associations, not diagnostic tools. Identifying this variant in your genetic profile does not mean you have or will develop Restless Legs Syndrome. RLS is a clinical diagnosis made by healthcare professionals based on symptoms, medical history, and physical examinations, not by genetic testing alone. If you are concerned about sleep quality, persistent leg discomfort, or other symptoms, you should consult with a physician or a sleep specialist. They can provide appropriate testing and discuss evidence-based management strategies, such as iron supplementation or lifestyle adjustments, if necessary. Never use genetic information to make medical decisions or change treatments without professional guidance. Always prioritize clinical evaluation over direct-to-consumer genetic reports when managing your health.
How common is this variant?
The minor allele frequency for rs7359837 is approximately 0.35 to 0.45 across European and Asian populations, making it a common genetic variant.
Frequently asked questions
Does having the rs7359837 variant mean I have Restless Legs Syndrome?
No. This variant is a statistical risk factor, not a diagnostic test. Many people carry this variant without ever experiencing symptoms of RLS.
Can I use this genetic information to diagnose my sleep problems?
No. Genetic testing cannot diagnose sleep disorders. If you are experiencing sleep issues, you should consult a doctor for a proper clinical evaluation.
Is there a cure for RLS if I have this genetic risk?
RLS is a complex condition managed by healthcare providers through various treatments, including iron therapy and lifestyle changes. You should discuss any concerns about treatment with your clinician.
Why is MEIS1 important for sleep?
MEIS1 is a transcription factor involved in nervous system development and iron regulation. Research suggests that its expression levels are linked to the biological pathways underlying RLS.
Sources & further reading
Educational information only, last refreshed 10/11/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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A fine-mapped regulatory variant within the MEIS1 locus associated with restless legs syndrome and periodic limb movements during sleep.
This intronic regulatory variant in MEIS1 is a primary risk locus for restless legs syndrome, influencing gene expression in the developing telencephalon.
This intronic variant in the MEIS1 gene is one of the most robustly replicated genetic risk factors for restless legs syndrome (RLS) and periodic limb movements of sleep.
Intronic regulatory variant within MEIS1 strongly implicated in periodic limb movements during sleep and restless legs syndrome etiology.
A 3' UTR variant in MEIS1 associated with periodic limb movement in sleep, restless legs syndrome, and insomnia symptoms.
Non-coding regulatory variant in MEIS1 that is strongly associated with periodic limb movements during sleep and symptom severity in restless legs syndrome.