MEIS1 rs113883650: Understanding Your Genetic Association
The rs113883650 variant is a genetic marker located within the MEIS1 gene, which has been identified through genome-wide association studies. It is primarily associated with an increased likelihood of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS).
What each genotype means
Typical risk profile
You carry two copies of the baseline A allele at this MEIS1 locus. Research has not associated this genotype with increased susceptibility to restless legs syndrome or nocturnal periodic limb movements. While this profile reflects standard population risk, general factors such as iron levels and sleep patterns still influence sleep quality.
Carried by approximately 60% to 65% of individuals of European ancestry, and by nearly 100% of individuals in African and East Asian populations.
Moderately increased RLS susceptibility
You carry one copy of the G risk allele within the MEIS1 regulatory region. Population studies associate this genotype with a modest statistical increase in the risk of experiencing restless legs syndrome and periodic limb movements during sleep. Carrying this variant does not cause symptoms on its own, as clinical presentation is heavily influenced by factors such as iron status and lifestyle triggers.
Found in approximately 30% to 35% of people of European ancestry, but it is rare or absent in African and East Asian cohorts.
Elevated RLS susceptibility
You carry two copies of the G risk allele in this MEIS1 non-coding regulatory region. In European cohort studies, carrying two risk alleles is statistically correlated with a higher likelihood of developing restless legs syndrome and associated nighttime leg movements compared to non-carriers. Many individuals with this genotype never develop symptoms, as this genetic factor acts as a risk modifier rather than a direct medical diagnosis.
Present in roughly 3% to 5% of individuals of European descent, while remaining extremely rare in African and East Asian ancestries.
What is rs113883650?
The rs113883650 variant is a single nucleotide polymorphism (SNP) located within the MEIS1 gene locus. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is categorized as a regulatory SNP, meaning it is situated in a non-coding region of the genome that helps control how the MEIS1 gene is expressed. Research indicates that this variant sits within a highly conserved intronic region, which acts as an enhancer element. Enhancers are DNA sequences that increase the likelihood of transcription of a particular gene. By influencing the activity of MEIS1, this variant may alter the gene's expression levels in specific tissues, such as the developing forebrain, which is thought to be relevant to sleep-related neurological processes.
The Role of the MEIS1 Gene
The MEIS1 gene encodes a transcription factor that belongs to the homeobox-containing family of proteins. Transcription factors are essential proteins that bind to specific DNA sequences to regulate the flow of genetic information from DNA to messenger RNA. MEIS1 plays a critical role in developmental biology, particularly in the maturation of neurons and the development of the central nervous system. Because it is involved in complex developmental pathways, researchers have long investigated its influence on neurological health. In the context of sleep disorders, MEIS1 is believed to be involved in the regulation of pathways that govern motor control and sleep-wake cycles. While the exact biological mechanism linking MEIS1 to sleep disorders is still being explored, its function as a master regulator of gene expression makes it a primary candidate for understanding the genetic architecture of sleep-related conditions.
Research Associations and Evidence
The association between MEIS1 and restless legs syndrome (RLS) is one of the most robust findings in the field of sleep genetics. Genome-wide association studies (GWAS) have consistently identified variants in the MEIS1 locus as significant risk factors for RLS and periodic limb movements during sleep (PLMS). The evidence for this association is considered moderate to strong, as it has been replicated across multiple independent cohorts. Researchers have used fine-mapping techniques to narrow down the specific regulatory elements within the MEIS1 gene that contribute to this risk. While the statistical association is clear, it is important to note that these findings are based on population-level data. Having a risk-associated genotype does not guarantee that an individual will develop a sleep disorder, as RLS is a complex condition influenced by a combination of genetic, environmental, and lifestyle factors.
Population Frequency
The frequency of the rs113883650 variant varies significantly across different ancestral groups. In European cohorts, the minor allele frequency (MAF) is approximately 0.20, making it a relatively common variant in these populations. Conversely, the variant is reported to be rare in African populations. These differences in allele frequency highlight the importance of considering ancestral background when interpreting genetic data. Because the variant is more prevalent in certain populations, the genetic contribution to RLS risk may differ depending on an individual's heritage. Understanding these frequency distributions is a key component of modern genomic research, as it helps scientists refine their models of disease risk and ensures that genetic findings are interpreted within the appropriate demographic context.
Interpreting Your Genetic Information
Genetic information regarding variants like rs113883650 is intended for educational purposes and should not be used for medical diagnosis or self-treatment. While research has established a statistical link between this variant and sleep disorders, it is only one piece of a much larger puzzle. Many other genetic and non-genetic factors contribute to the development of RLS and PLMS. If you are experiencing symptoms such as uncomfortable sensations in your legs or repetitive limb movements that disrupt your sleep, it is important to consult with a healthcare professional. A doctor can provide a clinical evaluation, discuss your symptoms, and determine the appropriate diagnostic steps or management strategies. Never make changes to your health regimen or medication based on genetic test results without first speaking with your clinician or pharmacist.
How common is this variant?
The minor allele frequency for rs113883650 is approximately 0.20 in European cohorts, while the variant is rare in African populations.
Frequently asked questions
Does having the risk variant mean I will get restless legs syndrome?
No, having a risk-associated genotype does not mean you will develop the condition. RLS is a complex disorder influenced by many genetic and environmental factors, and the variant only represents a statistical increase in risk.
Can I use this information to diagnose myself?
No, genetic variants cannot be used for self-diagnosis. If you are concerned about your sleep quality or leg sensations, please consult a healthcare provider for a professional assessment.
Is MEIS1 the only gene linked to restless legs syndrome?
No, RLS is a polygenic condition, meaning it is associated with multiple genes. While MEIS1 is a well-known risk locus, other genes have also been identified in various genome-wide association studies.
What should I do if I have the risk genotype?
You do not need to take specific action based on this genotype alone. If you are experiencing symptoms of a sleep disorder, discuss your concerns and your genetic information with your doctor.
Sources & further reading
Educational information only, last refreshed 10/24/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This intronic regulatory variant in MEIS1 is a primary risk locus for restless legs syndrome, influencing gene expression in the developing telencephalon.
This intronic variant in the MEIS1 gene is one of the most robustly replicated genetic risk factors for restless legs syndrome (RLS) and periodic limb movements of sleep.
Intronic SNP strongly predisposing individuals to Restless Legs Syndrome and periodic limb movements during sleep.
Intronic regulatory variant within MEIS1 strongly implicated in periodic limb movements during sleep and restless legs syndrome etiology.
A 3' UTR variant in MEIS1 associated with periodic limb movement in sleep, restless legs syndrome, and insomnia symptoms.
Non-coding regulatory variant in MEIS1 that is strongly associated with periodic limb movements during sleep and symptom severity in restless legs syndrome.