MEIS1 rs10757279: What Your Genotype Means
The rs10757279 variant is a specific change in the DNA sequence located within the MEIS1 gene. It is widely recognized in scientific literature as a significant genetic marker associated with an increased risk of developing restless legs syndrome (RLS) and periodic limb movements in sleep.
What each genotype means
Typical risk profile
You carry two copies of the non-risk A allele at this MEIS1 locus. Research indicates that this genotype is associated with baseline population risk for restless legs syndrome (RLS) and periodic limb movements in sleep. Having this genotype does not guarantee you will never develop sleep-related movement symptoms, as overall susceptibility depends on lifestyle, iron status, and other genetic determinants.
Found in approximately 45% to 50% of individuals of European ancestry and at higher rates in East Asian populations.
Moderately increased risk
You carry one copy of the risk-associated G allele in the MEIS1 gene. Population studies associate this genotype with a moderately elevated likelihood of developing restless legs syndrome and periodic limb movements during sleep. Because this marker functions as a risk modifier rather than a direct diagnostic determinant, many carriers never experience clinical symptoms.
Carried by roughly 40% to 45% of individuals of European ancestry; less common in East Asian populations.
Elevated risk profile
You carry two copies of the risk-associated G allele in the intronic regulatory region of MEIS1. Research correlates this genotype with decreased MEIS1 expression and the highest relative genetic susceptibility to restless legs syndrome and periodic limb movements in sleep within this locus. This finding represents a statistical predisposition rather than a clinical diagnosis, and factors such as peripheral iron levels play a significant role in symptom presentation.
Carried by approximately 8% to 10% of individuals of European ancestry; observed at significantly lower frequencies in East Asian populations.
Understanding the Variant and Its Location
The variant rs10757279 is a single nucleotide polymorphism (SNP) situated within the MEIS1 gene on chromosome 2. In genetics, an intronic variant like this one resides in a non-coding region of the gene, meaning it does not provide the direct instructions for building the MEIS1 protein itself. Instead, such variants often function as regulatory elements that influence how much of the protein is produced or when it is expressed in specific tissues. Because this SNP is located in a region that helps control gene activity, researchers study it to understand how it might alter the normal biological processes in the brain or nervous system. It is one of several markers in this genomic region that have been identified through large-scale genome-wide association studies (GWAS) as being statistically linked to sleep-related movement disorders.
The Role of the MEIS1 Gene
The MEIS1 gene encodes a transcription factor, which is a protein that acts like a master switch to turn other genes on or off. This protein is crucial for normal development, particularly in the formation of the nervous system and the limbs. Research suggests that MEIS1 plays a vital role in neurogenesis, the process by which new neurons are generated, and in establishing the connections between neurons. Beyond its developmental roles, studies have indicated that MEIS1 is involved in maintaining iron homeostasis within the brain. Iron is a critical nutrient for proper neurological function, and disturbances in iron metabolism are a well-known feature of restless legs syndrome. By influencing the expression of genes related to iron transport and storage, MEIS1 may help regulate the delicate chemical balance required for healthy sleep and motor control.
Research Associations and Evidence Strength
The association between the MEIS1 locus and restless legs syndrome (RLS) is considered one of the most robust and reproducible findings in the field of sleep genetics. Multiple large-scale meta-analyses have confirmed that variants in this region are strongly linked to the risk of RLS and periodic limb movements during sleep. While the statistical evidence for an association is strong, it is important to note that this is a complex trait. Having a specific genotype at this location does not mean an individual will definitely develop the condition; rather, it indicates a higher statistical probability compared to the general population. The evidence is primarily derived from studies of individuals of European ancestry, and while the signal is consistent, the exact biological mechanisms are still being investigated. Current research continues to explore how these intronic variants influence the brain's development and iron regulation to contribute to the symptoms of RLS.
Population Frequency
The frequency of the alleles associated with rs10757279 varies across different ancestral groups. In populations of European descent, the minor allele frequency is approximately 0.30, making it a relatively common variant. The frequency is generally observed to be lower in East Asian populations. Because this variant is common, it is found in a significant portion of the healthy population who do not have restless legs syndrome, which underscores that genetics is only one piece of the puzzle. Environmental factors, lifestyle, and other genetic markers also play significant roles in the development of sleep disorders. Understanding these frequencies helps researchers design better studies to account for ancestral diversity and ensures that findings are interpreted within the correct context of global human genetic variation.
What This Information Means for You
It is important to understand that genetic variants like rs10757279 are tools for scientific research, not diagnostic tests. If you are experiencing symptoms such as an irresistible urge to move your legs, particularly at night, or if you have concerns about your sleep quality, you should consult a healthcare professional. A doctor can evaluate your symptoms, medical history, and iron levels to provide an accurate diagnosis and discuss appropriate management strategies. You cannot use this genetic information to diagnose yourself or predict your future health with certainty. Genetic associations are based on population-level data and do not account for the unique combination of factors that influence an individual's health. Always rely on clinical evaluation by a qualified provider rather than direct-to-consumer genetic reports when making decisions about your health or medical care.
How common is this variant?
The minor allele frequency for this variant is approximately 0.30 in European populations, with lower frequencies observed in East Asian populations.
Frequently asked questions
Does having the risk genotype mean I will get restless legs syndrome?
No, having a specific genotype does not guarantee that you will develop restless legs syndrome. Genetic risk factors only increase the statistical probability of a condition, and many people with the risk genotype never develop symptoms.
Can I use this SNP to diagnose RLS?
No, this SNP cannot be used for diagnosis. Restless legs syndrome is a clinical diagnosis made by a doctor based on your symptoms, medical history, and physical examination.
Is there a cure for RLS if I have this genetic variant?
There is no genetic cure for RLS. However, doctors can manage the condition through lifestyle changes, iron supplementation if levels are low, and various medications, which should always be discussed with your clinician.
Why is MEIS1 linked to iron levels?
Research suggests that MEIS1 helps regulate genes involved in iron transport and storage. Since iron deficiency is a known trigger for RLS symptoms, the gene's influence on iron metabolism is a key area of study for understanding the disorder.
Sources & further reading
Educational information only, last refreshed 10/19/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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A fine-mapped regulatory variant within the MEIS1 locus associated with restless legs syndrome and periodic limb movements during sleep.
This intronic regulatory variant in MEIS1 is a primary risk locus for restless legs syndrome, influencing gene expression in the developing telencephalon.
This intronic variant in the MEIS1 gene is one of the most robustly replicated genetic risk factors for restless legs syndrome (RLS) and periodic limb movements of sleep.
Intronic SNP strongly predisposing individuals to Restless Legs Syndrome and periodic limb movements during sleep.
Intronic regulatory variant within MEIS1 strongly implicated in periodic limb movements during sleep and restless legs syndrome etiology.
A 3' UTR variant in MEIS1 associated with periodic limb movement in sleep, restless legs syndrome, and insomnia symptoms.